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Yilmaz N.,Central Laboratories of Antalya Education and Research Hospital of Ministry of Health | Aydin O.,Central Laboratories of Antalya Education and Research Hospital of Ministry of Health | Yegin A.,Central Laboratories of Antalya Education and Research Hospital of Ministry of Health | Tiltak A.,Neurology Clinic of Antalya Education and Research Hospital of Ministry of Health | Aykal G.,Central Laboratories of Antalya Education and Research Hospital of Ministry of Health
Biochemia Medica | Year: 2011

Introduction: The nature of the relationship between glucose metabolism and occurrence of migraine has not been elucidated precisely. This study investigated the status of oxidative/antioxidative balance and its relationship with the glucose metabolism in migraineurs to get new points ofview for the underlying oxidative mechanisms. Materials and methods: Sixty migraineurs and 46 control subjects were included in the study. Oxidative stress index, total oxidant and antioxidant status of both groups were examined in addition to the insulin and HOMA-IR index levels. Results: HOMA-IR index was significantly enhanced in migraineurs (P = 0.038); similarly oxidative stress index and total oxidant status were higher in patients compared to the controls (P < 0.001 for both). Conclusion: This preliminary study shows that oxidative/antioxidative balance shifts towards the oxidative status in migraine. Higher total oxidant status and elevated HOMA-IR index might play a role in the potential early pathogenesis for migraine. Source


Ellidag H.,Central Laboratories of Antalya Education and Research Hospital of Ministry of Health | Kurtulus F.,Neurology Clinic of Antalya Education and Research Hospital of Ministry of Health | Yaman A.,Neurology Clinic of Antalya Education and Research Hospital of Ministry of Health | Ylmaz N.,Central Laboratories of Antalya Education and Research Hospital of Ministry of Health | And 2 more authors.
Neurochemical Journal | Year: 2014

The impact and pathogenesis of iron accumulation in multiple sclerosis (MS) is not yet clear. In this study, we investigated serum markers of iron metabolism, namely iron, ferritin, transferrin, total iron binding capacity (TIBC), and hepcidin in patients with MS, and compared to a healthy control group. Thirty-five stable relapse remitting MS patients (15 males and 20 females; mean age 38 ± 11 years) and thirty-five age-sex matched healthy controls (13 males and 22 females; mean age 38 ± 10 years) were included in this study. All patients were diagnosed with MS, according to the criteria of McDonald. Serum transferrin and TIBC levels were significantly lower (p = 0.02 and p = 0.03, respectively), whereas hepcidin, iron and ferritin values did not show any significant difference (p = 0.8, p = 0.2 and p = 0.8, respectively) in patients with MS compared to controls. There was no statistically significant correlation between iron metabolism markers and disease duration, Expanded Disability Status Scale and progression index. Our results were as expected from a chronic disease; thus were in favor of local, rather than a systemic impairment in iron metabolism in these patients. Our study, contributes to the establishment of further hypotheses on the role of hepcidin and iron metabolism in MS. © 2014, Pleiades Publishing, Ltd. Source


Aydin O.,Biochemistry Laboratory | Ellidag H.Y.,Central Laboratories of Antalya Education and Research Hospital of Ministry of Health | Kurtulus F.,Neurology Clinic of Antalya Education and Research Hospital of Ministry of Health | Yaman A.,Neurology Clinic of Antalya Education and Research Hospital of Ministry of Health | Yilmaz N.,Central Laboratories of Antalya Education and Research Hospital of Ministry of Health
Biochemia Medica | Year: 2014

Introduction: Oligodendrocytes need iron in processes of energy generation and myelination. However, excessive levels of iron may exert iron induced oxidative stress and thus lead to tissue degeneration. Monitoring oxidative stress will be of paramount importance in follow-up of patients with many diseases including multiple sclerosis (MS). The aim of this study was to measure total anti-oxidative status (TAS), total oxidative status (TOS) and ischemia modified albumin (IMA) in stable relapse remitting MS (RRMS) patients.Materials and methods: Thirty-five RRMS patients (15 males and 20 females; median age 42 (20-55) years) and thirty-five age-sex matched healthy controls (13 males and 22 females; median age 37 (21-60) years) were included in this study. All patients were diagnosed with MS according to the criteria of McDonald.Results: IMA levels were significantly higher in RRMS patients (P < 0.001), while TAS and TOS did not show any significant difference between groups (P = 0.870 and P = 0.460, respectively).Conclusions: Our results suggest IMA as a more efficient serum marker than TAS and TOS in detecting the oxidative stress in MS patients. Serum oxidative stress markers should be included in future study protocols besides clinical and radiological parameters. © 2014 by Croatian Society of Medical Biochemistry and Laboratory Medicine. Source


Aydin O.,Biochemistry Laboratory | Aydin O.,Antalya Education and Research Hospital | Kurtulus F.,Neurology Clinic of Antalya Education and Research Hospital of Ministry of Health | Ellidag H.Y.,Central Laboratories of Antalya Education and Research Hospital of Ministry of Health | And 2 more authors.
Neurochemical Journal | Year: 2015

As anti-oxidative therapies come into consideration, finding feasible markers of oxidative stress becomes mandatory. We here in this study investigated the levels of major internal antioxidant uric acid (UA), oxidative stress parameters total antioxidant status (TAS), total oxidative status (TOS) in multiple sclerosis (MS) patients compared to controls. Thirty-five stable relapse remitting MS patients (15 males and 20 females; mean age 38 ± 11 years) and thirty-five age-sex matched healthy controls (13 males and 22 females; mean age 38 ± 10 years) were included in this study. All patients were diagnosed with MS according to the criteria of McDonald. Serum UA levels were significantly lower in the MS group (p = 0.03). When MS patients were sub-classified according to gender, female patients showed lower UA levels compared to male patients (p = 0.01). We did not find statistically significant differences in TAS and TOS between patients and controls. Serum UA correlated well with serum TAS as expected. However the correlation was more powerful in MS group (p < 0.0001 in MS group versus p = 0.02 in controls). Interpreting sole measurements of oxidative stress parameters may be deceptive as their values depend on many factors including serum levels of each other. We believe in the superiority of using TAS and TOS as markers of oxidative stress in MS patients as they inform about totals, independent of levels of individual parameters. © 2015, Pleiades Publishing, Ltd. Source

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