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Chen Y.,Neuroelectrophysiological Center | Cui Z.-T.,Daqing Oil Field General Hospital | Wang X.-H.,Daqing Oil Field General Hospital | Cao L.-H.,Daqing Oil Field General Hospital | Wu Y.,Daqing Oil Field General Hospital
Chinese Journal of Neurology | Year: 2010

Objective: To explore the diagnostic value of tibial nerve short-latency somatosensory evoked potential(SLSEP) and F wave in proximal diabetic neuropathy. Methods: Excluding stroke, waist cervical vertebra sickness and nerve-muscle diseases caused by other diseases, there were clinical signs of neuropathy but normal nerve conduction EMG (I group) 32 cases, there weren't clinical signs of neuropathy normal nerve conduction EMG(II group) 30 cases and abnormal nerve conduction EMG (III group) 30 cases. Tibial nerve SLSEP and F wave were measured in 92 patients and 30 normal persons. Results: The highest whole abnormality rate of tibial nerve SLSEP's and F wave's all parameters was the sub-group (there were neuropathy symptom lower limbs n =43) of I group(97.7% (42/43)). In I group F dur, N13CV, N24CV, N13-N24CV, N9-N24CV were significantly different from the control group (q value; 5.887 and 6.780, -4.568 and -5.062, -6.799 and -6.905, -5.978 and -5.609, -5.433 and -5.190, P < 0.01); The abnormality rate of F dur and N13-N24CV(25. 0% (15/60), 23.3% (14/60)) in II group were significantly different from the control group (0, 1.7% (1/60)) also(X 2 =17.143, 12.876, both P = 0.0050). In III group, except for N9-N24CV, N13 and N24 wave amplitude other parameters' abnormality rates were significantly different from the control group, and the abnormality rate of N9CV was the highest (76.7% (46/60)). Conclusion: (1) SLSEP can provide information of proximal sensory nerve segment. (2) SLSEP and F wave can improve the diagnosis rate of proximal diabetic neuropathy, and the diagnostic value is particularly significant to the diabetes patients who have clinical signs of neuropathy but normal nerve conduction EMG. Source

Li X.,Chongqing Medical University | Li X.,Neuroelectrophysiological Center | Shao X.,Neuroelectrophysiological Center | Wang N.,Neuroelectrophysiological Center | And 3 more authors.
Brain Research | Year: 2010

This study was aimed to examine the changes in auditory event-related potentials (AERPs) and their relationship with brain metabolic changes in mild cognitive impairment (MCI). 34 MCI patients and 34 healthy elderly controls were subjected to auditory stimulus oddball task, and then post-stimulus potentials (P50, N100, P200, N200, and P300) were obtained, levels of N-acetylaspartate (NAA), creatine (Cr) and the ratio of NAA/Cr were measured by proton magnetic resonance spectroscopy (1H-MRS) in left frontal, left temporal and right parietal cortex. Compared with the control group, the MCI group had significantly increased P50 amplitudes and P300 latency, and the NAA/Cr was abnormal. Linear progression analysis revealed a strong negative correlation between P50 amplitudes and NAA/Cr in left frontal cortex, and negative correlation between P300 latency and NAA/Cr in left frontal and left temporal, as well as correlation of AERP components and MRS metabolites with clinical scores of cognitive tests. These findings suggest that metabolic abnormalities of different brain regions may reflect the changes of underlying brain activities that are instrumental in the MCI. Therefore AERPs and MRS measurements may offer a mean to track changes of brain activities associated with functional changes, and to assess early cognitive impairment in MCI. © 2010 Elsevier B.V. Source

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