Net Pharmacy College

Rāichūr, India

Net Pharmacy College

Rāichūr, India
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Setty C.M.,P.A. College | Babubhai S.R.,Net Pharmacy College
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2010

Topical gels of valdecoxib were prepared using two different gelling agents (viz, carbopol and hydroxypropylmethylcellulose). Formulations were evaluated for pH, rheological behavior, drug content and in vitro drug diffusion. Formulations of both the gelling agents appeared to be non-Newtonian and pseudo plastic. Drug content was found to be high (>98%) and uniform in gels. Effect of solvents, propylene glycol and ethanol on the release of drug from the gels was studied. Drug release from the gels increased with increase in the concentration of propylene glycol up to 10%. However, drug release decreased with further increase in the concentration of the propylene glycol to 20%. In case of carbopol gels, drug release increased with the addition of ethanol. However, in case of hydroxypropylmethylcellulose gels, addition of ethanol decreased the release of valdecoxib. The release of VLD from the gels followed the Higuchi model. It can be concluded that propylene glycol acts as a good solvent in carbopol and hydroxypropylmethylcellulose based valdecoxib gels.

Sarfaraz M.D.,Jawaharlal Nehru University | Sarfaraz M.D.,Net Pharmacy College | Joshi V.G.,Jawaharlal Nehru University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Objective: In the present investigation an attempt was made to develop immediate release solid dosage form of salbutamol sulphate. Salbutamol sulphate a selective β2 receptor agonist is widely used in initial therapy for chronic as well as acute asthma, an inflammatory disorder characterized by obstruction of air pathways and difficulty in breathing. The currently available conventional oral dosage forms are associated with lag time and delayed onset of action while aerosols and parenterals inspite of rapid onset of action strongly affect the patience compliance. Immediate release tablets are highly accepted fast growing drug delivery systems and thus, an attempt was made to improve the onset of action of drug. Methods: To achieve this goal, selective superdisintegrants croscarmellose sodium, crospovidone and sodium starch glycolate in different concentrations (2.5 - 7.5%w/w), were evaluated for their effect on the disintegration behavior of tablets, while microcrystalline cellulose and lactose were used as diluents. The tablets were prepared by direct compression method and were evaluated for various physicochemical properties, FTIR, in vitro disintegration and in vitro drug release studies. Results: Out of nine formulations prepared tablet F3 containing 7.5% w/w of Croscarmellose sodium disintegrated in 89±2.08 seconds and released 99.26% and 99.75% of drug in 12 minutes in pH 6.8 and pH 7.4 phosphate buffer respectively and thereby selected as best formula.. FTIR studies revealed no chemical interaction between the drug and excipients used. Conclusion: The tablets gave fast release of salbutamol sulfate which produces fast action in asthmatic attacks and may serve as a successful strategy for enhancing the bioavailability of drug.

Prakash P.R.,Net Pharmacy College | Soujanya C.,Net Pharmacy College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2010

The present research has been undertaken with the aim to develop a topical gel formulation of etoricoxib, which would attenuate the gastrointestinal relater toxicities associated with oral administration. Etoricoxib is a highly selective cyclooxygenase-2 (cox-2) inhibitor. In the present study gels with carbopol, HPMC K4M, MC, HPC were prepared with different permeation enhancers like, DMSO, lemongrass oil, menthe oil, oleic acid. They were evaluated for physicochemical properties, drug release. After in vitro evaluation of gel formulations, ex vivo permeation of etoricoxib was evaluated across rat epidermis and human cadaver skin. The best formulation was then evaluated for the anti-inflammatory and skin irritation study. And were kept for stability studies for period of three months and found that they were stable and finally it was concluded that the formulation F25 was the best and comparable with that of marketed product.

Sarfaraz M.,Net Pharmacy College | Keerthi Chandra Reddy P.,Net Pharmacy College | Udupi R.H.,Net Pharmacy College | Doddayya H.,Net Pharmacy College
International Journal of Drug Development and Research | Year: 2012

The present investigation concerns the development of bilayer floating tablets of Tramadol hydrochloride (TH) for prolongation of gastric residence time. TH is a synthetic opioid analgesic used to treat moderate to severe pain. An attempt was made to prepare bilayered floating tablets of TH by wet granulation method using release retarding polymers like hydroxypropyl methyl cellulose grades (HPMC K4M, K15M, K100M), PEO, Sodium alginate and sodium bicarbonate as gas generating agent, with a view to deliver the drug at sustained or controlled manner in gastrointestinal tract and consequently in to systemic circulation. Five formulations were prepared and evaluated for compatibility study, buoyancy lag time, total floating time, swelling study, in-vitro disintegration and in-vitro dissolution studies. Formulations were found uniform with respect to thickness (5.04 to 5.07 mm) and hardness (6.3 to 6.6 kg/cm2). The friability (0.29 to 0.37%), weight variation (1.44 to 1.71%) and Drug content (98.73 to 99.23%) of different batch of tablets were found within prescribed limits. Formulation F3 selected as best formulation, shown buoyancy lag time of 39 sec, total floating time of 36 hrs and drug release of 95.90% in a period of 24 hrs. Tablets followed diffusion controlled first order kinetics and nonfickian transport of the drug. FTIR study revealed the absence of any chemical interaction between drug and polymers used. © 2012 IJDDR.

Goudanavar P.,Net Pharmacy College | Shah S.H.,Net Pharmacy College | Hiremath D.,Net Pharmacy College
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011

The present study aimed at preparing Orodispersible tablets of lamotrigine by forming inclusion complex with hydroxypropyl β-cyclodextrin (HPβCD) employing kneading method. The complex was compressed into tablets along with superdisintegrants such as Kyron T-314, Sodium starch glycolate, Indion 414, Croscarmellose sodium and crospovidone in different concentration. Bitter taste of drug is successfully masked by HPβCD complex and is also useful to enhance the solubility which was confirmed by phase solubility analysis. Orodispersible tablets were characterized by Fourier Transform Infrared (FTIR) Spectroscopy, Differential Scanning Calorimetry (DSC) and Powder X-ray Diffraction Analysis (PXRD). The prepared tablets were evaluated for weight variation, thickness, hardness, friability, in vitro dispersion time, wetting time, in vitro disintegration time, drug content and in vitro drug release. In vitro dispersion time decreases with increase in concentration of all superdisintegrants. Result revealed that F6 had shown short dispersion time with maximum drug release in 12 minutes. Formulation containing higher concentration of Indion 414 decreases disintegration time (22.71 sec) and optimize the drug release (99.09% in 12 minutes).

Arshad Ahmed K.K.,Net Pharmacy College | Sarfaraz M.D.,Net Pharmacy College | Doddayya H.,Net Pharmacy College
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011

Aceclofenac is a novel anti-inflammatory, analgesic and antipyretic drug that is currently approved for the treatment of acute and chronic rheumatoid arthritis and osteoarthritis. It exhibits very slight solubility in water, poor flow and compression characteristics. Hence directly compressible aceclofenac-disintegrant agglomerates with improved water solubility, flow and compression characteristics were obtained by novel crystallo-co-agglomeration (CCA) technique. Aceclofenac agglomerates were prepared by using a three solvent system comprising of acetone: DCM: water. Acetone-water containing PEG 6000, HPC and disintegrants like SSG, CP and pregelatinised starch in different concentrations were used as the crystallization medium. Precompressional parameters of agglomerates were found within limits. The prepared tablets were evaluated for weight variation, thickness, hardness, friability, in vitro dispersion time, wetting time, in vitro disintegration time, drug content and in vitro drug release. Optimized fast dissolving tablets were characterized by FTIR, DSC and PXRD studies. In vitro dispersion time decreases with increase in concentration of all superdisintegrants. Among all the formulations studied, F6 prepared by incorporation of CP (18.43%) had shown short dispersion time with maximum drug release. Formulation F6 showed least disintegration time (18.03 sec) and optimized the drug release (99.13% in 8 min).

Chandramouli,Net Pharmacy College | Shivanand M.R.,Net Pharmacy College | Nayanbhai T.B.,Net Pharmacy College | Bheemachari,Net Pharmacy College | Udupi R.H.,Net Pharmacy College
Journal of Chemical and Pharmaceutical Research | Year: 2012

3-Substituted-4-amino-5-mercapto-1, 2, 4-triazole (3) was obtained in an excellent yield in a single step by the condensation of a well known drug norfloxacin having free carboxyl group (1) with thiocarbohydrazide (2). Various 3-Substituted-4-amino-5-mercapto-1, 2, 4-triazoloSchiff bases (4a1-a11) have been synthesized by the condensation of the mercapto triazole (3) with different aromatic aldehydes. The triazolo Schiff bases (4a1-a11) on heating with 2-Amino-7-chloro-6-fluorobenzothiazole in equimolar proportions yielded the required 3-Substitued-5-(2'-imino-7- chloro-6-fluorobenzothiazolyl) 1, 2, 4-triazolo Schiff bases (5a1-a11). The structures of newly synthesized compounds have been established on the basis of their spectral data and elemental analysis. Some selected compounds were screened for analgesic and anti-inflammatory activity. Some of the compounds exhibited encouraging results.

Kumar S.,Net Pharmacy College | Alagawadi K.,KLE University | Rao M.,Net Pharmacy College
Indian Journal of Pharmacology | Year: 2011

Objectives: To evaluate the antiobesity effects of the ethanolic extract of Argyreia speciosa roots in rats fed with a cafeteria diet (CD). Materials and Methods: Obesity was induced in albino rats by feeding them a CD daily for 42 days, in addition to a normal diet. Body weight and food intake was measured initially and then every week thereafter. On day 42, the serum biochemical parameters were estimated and the animals were sacrificed with an overdose of ether. The, liver and parametrial adipose tissues were removed and weighed immediately. The liver triglyceride content was estimated. The influence of the extract on the pancreatic lipase activity was also determined by measuring the rate of release of oleic acid from triolein. Results: The body weight at two-to-six weeks and the final parametrial adipose tissue weights were significantly lowered (P < 0.01 and P < 0.05, respectively) in rats fed with the CD with Argyreia speciosa extract 500 mg/kg/day as compared to the CD alone. The extract also significantly reduced (P < 0.01) the serum contents of leptin, total cholesterol, low density lipoprotein (LDL), and triglycerides, which were elevated in rats fed with CD alone. In addition, the extract inhibited the induction of fatty liver with the accumulation of hepatic triglycerides. The extract also showed inhibition of pancreatic lipase activity by using triolein as a substrate. Conclusions: The ethanolic extract of Argyreia speciosa roots produces inhibitory effects on cafeteria diet-induced obesity in rats.

Ramaprasad G.C.,Mangalore University | Ramaprasad G.C.,Biocon | Kalluraya B.,Mangalore University | Kumar B.S.,Net Pharmacy College | Hunnur R.K.,Net Pharmacy College
European Journal of Medicinal Chemistry | Year: 2010

A series of biphenyl-1,3,4-oxadiazoles namely 5-[substituted-(1,1′- biphenyl)-3-yl]-1,3,4-oxadiazole-2(3H)-thiones and its S-alkyl derivatives have been synthesized by multi step organic synthesis involving Suzuki-Miyaura coupling using palladium catalyst. The synthesized compounds were characterized by 1H NMR, 13C NMR, 19F NMR, IR and LCMS spectroscopic properties. They were tested for their antimicrobial and analgesic activities. Some of them showed significant activity. © 2010 Elsevier Masson SAS. All rights reserved.

Puthiyapurayil P.,Mangalore University | Puthiyapurayil P.,Biocon | Poojary B.,Mangalore University | Chikkanna C.,SDM College Ujire | Buridipad S.K.,NET Pharmacy College
European Journal of Medicinal Chemistry | Year: 2012

On account of the reported anticancer activity of triazolothiadiazines, we have synthesized a novel series of 6-arylsubstituted-3-[2-(4-substitutedphenyl) propan-2-yl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and tested for in-vitro cytotoxicity by trypan blue exclusion and MTT assay. These compounds were also evaluated for their in-vivo anthelmintic activity, as well as in-vitro antimicrobial studies. Amongst the tested compounds, the compound 7j was the most promising cytotoxic agent with IC50 value of 10.54 μM in MCF-7 cells. The compounds 7l and 7q exhibited excellent anthelmintic activity. The compounds 7d, 7f, 7j, 7l, 7o, 7p and 7r showed good antibacterial activity, whereas compounds 7e and 7k exhibited excellent antifungal activity. The structures of newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and LCMS analysis. © 2012 Elsevier Masson SAS. All rights reserved.

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