Khamaisie H.,Galilee Technology Center |
Sussan S.,Galilee Technology Center |
Tal M.,Galilee Technology Center |
Tal M.,Ness Technologies |
And 4 more authors.
Anticancer Research | Year: 2011
The hallmark of chronic myeloid leukemia (CML) is the abnormal activity of p210Bcr-Abl kinase. Selective kinase inhibitors such as imatinib or nilotinib have been established successfully for the treatment of CML. Despite high rates of clinical response, CML patients can develop resistance to these kinase inhibitors mainly due to point mutations within the Abl kinase domain of the fusion protein. Previously, we reported that a crude extract of the mushroom Daedalea gibbosa inhibited kinase activity of Bcr-Abl kinase. Here we report on the identification of the active component of Daedalea gibbosa, oleic acid, which inhibited Bcr-Abl kinase autophosphorylation in Ba/F3 cells and exhibited anti-CML activity in a BCR/ABL-positive mouse model. Source
Barsky E.,Ness Technologies |
Bar-Ilan J.,Bar - Ilan University
Journal of the American Society for Information Science and Technology | Year: 2012
This experiment studied the impact of various task phrasings on the search process. Eighty-eight searchers performed four web search tasks prescribed by the researchers. Each task was linked to an existing target web page, containing a piece of text that served as the basis for the task. A matching phrasing was a task whose wording matched the text of the target page. A nonmatching phrasing was synonymous with the matching phrasing, but had no match with the target page. Searchers received tasks for both types in English and in Hebrew. The search process was logged. The findings confirm that task phrasing shapes the search process and outcome, and also user satisfaction. Each search stage-retrieval of the target page, visiting the target page, and finding the target answer-was associated with different phenomena; for example, target page retrieval was negatively affected by persistence in search patterns (e.g., use of phrases), user-originated keywords, shorter queries, and omitting key keywords from the queries. Searchers were easily driven away from the top-ranked target pages by lower-ranked pages with title tags matching the queries. Some searchers created consistently longer queries than other searchers, regardless of the task length. Several consistent behavior patterns that characterized the Hebrew language were uncovered, including the use of keyword modifications (replacing infinitive forms with nouns), omitting prefixes and articles, and preferences for the common language. The success self-assessment also depended on whether the wording of the answer matched the task phrasing. © 2012 ASIS & T. Source
Yafe E.,Ness Technologies
GEO: connexion | Year: 2013
In the modern world, management of a disaster depends on the ability to respond fast and in an effective way at various levels, according to responsibilities and authority, mainly in co-ordination between the various organisations and officials. Dealing effectively with disasters begins long before it happens. During the disaster, it's too late - you cannot invest the necessary resources to deal with the disaster if you haven't made the necessary preparations. Therefore, high-end, state-of-the-art systems are required to manage and control crises and disasters. One of the most important components of such a system, if not the most important, is its mapping element and GIS capabilities. Source
Ness Technologies | Date: 2012-10-23
Computer software and computer software development tools for design development, deployment, and management of open source and propriety computer software, namely, client-server computer software and web-based software for computer software developers to use as infrastructure to facilitate the design and development of open source and proprietary computer software.