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Sheeja B.,Government of Tamilnadu | Sindhu D.,Nesamony Memorial Christian College | Ebanasar J.,Government of Tamilnadu
Asian Pacific Journal of Tropical Disease | Year: 2012

Objective: The purpose of the present study was to assess the acetone and ethanol extracts of Andrographis paniculata against the filarial vector Culex quinquefasciatus. Methods: The ethanol and acetone extracts of plant leaves was used at 25, 50, 100, 200 and 300 ppm dilution in bioassays against second instar larvae of Culex quinquefasciatus. Ten larvae were exposed to the leaf extract at different concentration in a final volume of 100 mL formulation taken in 500 mL of glass bowl. For avoiding error triplicates were maintained. Tap water was taken as control. The larval mortality at different concentrations and in control was recorded 24 hour continuous exposure. Results: The toxicity of ethanol extract of Andrographis paniculata on survival of Culex quinquefasciatus reveals that the mortality is dependent on the dose of the plant extract and also on time of exposure. Highest mortality rate of 20% and 73.3% was recorded in 300 ppm at 3 and 24 h respectively. The similar trend was observed in case of the toxicity of acetone extract. Conclusions: The results of the present study suggest that the leaf extracts of Andrographis paniculata may have the potential to be used as an ideal eco-friendly approach for the control of the filarial vector Culex quinquefasciatus. © 2012 Asian Pacific Tropical Medicine Press. Source

Reji T.F.A.F.,Nesamony Memorial Christian College | Pearl A.J.,Scott Christian College | Rosy B.A.,Holy Cross College Autonomous
Journal of Rare Earths | Year: 2013

Lanthanide complexes of Eu(III), Gd(III), Nd(III), Sm(III), and Tb(III) with phenylthioacetic acid were synthesized and characterized by elemental analysis, mass, infrared radiation (IR), electronic spectra, molar conductance, thermogravimetric analysis (TGA), and powder X-ray diffraction (XRD). The results showed that the lanthanide complexes were homodinuclear in nature. The two lanthanide ions were bridged by eight oxygen atoms from four carboxylate groups. Thermal decomposition profiles were consistent with the proposed formulations. Powder XRD studies showed that all the complexes were amorphous in nature. Antimicrobial studies indicated that these complexes exhibited more activity than the ligand itself. The DNA cleavage activity of the ligand and its complexes were assayed on CT DNA using gel electrophoresis in the presence of H2O2. The result showed that the Eu(III) and Nd(III) complexes completely cleaved the DNA. The anticancer activities of the complexes were also studied towards human cervical cancer cell line (HeLa) and colon cancer cells (HCT116) and it was found that the Eu(III) and Nd(III) complexes were more active than the corresponding Gd(III), Sm(III), Tb(III) complexes and the free ligand on both the cancer cells. © 2013 The Chinese Society of Rare Earths. Source

Binish T.,Nesamony Memorial Christian College | Mary Suja R.,Scott Christian College
International Journal of Pharma and Bio Sciences | Year: 2015

Bio prospecting of plants with anti-proliferative activity has been a major focus on the search of plants based cure. The pharmacological importance of Ceropegia species (Apocynaceae) is mainly due to the presence of a pyridine alkaloid 'Ceropegin' a potential antipyretic, analgesic, local anesthetic, antiulcer, mast-cell stabilizing, hepato-protective, tranquilizing, and hypotensive. Use of plant derived compounds as potent anticancer agents is of recent research interest. In the continuing effort to screen Ceropegia species (Ceropegia spiralis, Ceropegia juncea, and Ceropegia candelabrum) for anticancer activity, plants were collected, micro propagated and hardening. In-vitro propagated plants are collected, extracts tested for the activity using cell lines namely HCT-118 (Colon cancer cell) of the extracts from three species of same families tested (10,50,and100μg/ml). 10ug ofCeropegia spiralis showed 47.15% of cell death, which can be considered significant. Apoptosis was confirmed by acridine orange (AO) ethidium bromide (EB) fluorescent double staining which confirms the potent anticancer effect of ethyl acetate fraction of Ceropegia spiralis. Source

Dhas D.A.,Nesamony Memorial Christian College | Joe I.H.,Center for Molecular and Biophysics Research | Roy S.D.D.,Nesamony Memorial Christian College | Balachandran S.,Mg College
Materials Today: Proceedings | Year: 2015

Density functional theory and vibrational analysis of 3-alkyl-4-amino-6-aryl-1,2,4-triazin-5-one herbicide has been carried out. The geometry has been optimized by B3LYP level of theories using 6-311G (df, p) basis set using Gaussian 09 program and compared with the crystal data. NBO and structural analysis has been carried out on the compound. Theoretical methods have been used to study the proper and improper hydrogen bonds, considering the hydrogen bond length and charge transfer. The Mulliken population analysis on atomic charges and the HOMO-LUMO energy were also calculated. © 2015 Elsevier Ltd. Source

Arul Dhas D.,Nesamony Memorial Christian College | Hubert Joe I.,Center for Molecular and Biophysics Research | Roy S.D.D.,Nesamony Memorial Christian College | Balachandran S.,Mg College
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2011

Vibrational analysis of the thionocarbamate fungicide tolnaftate which is antidermatophytic, antitrichophytic and antimycotic agent, primarily inhibits the ergosterol biosynthesis in the fungus, was carried out using NIR FT-Raman and FTIR spectroscopic techniques. The equilibrium geometry, various bonding features, harmonic vibrational wavenumbers and torsional potential energy surface (PES) scan studies have been computed using density functional theory method. The detailed interpretation of the vibrational spectra has been carried out with the aid of VEDA.4 program. Vibrational spectra, natural bonding orbital (NBO) analysis and optimized molecular structure show the clear evidence for electronic interaction of thionocarbamate group with aromatic ring. Predicted electronic absorption spectrum from TD-DFT calculation has been compared with the UV-vis spectrum. The Mulliken population analysis on atomic charges and the HOMO-LUMO energy were also calculated. Vibrational analysis reveals that the simultaneous IR and Raman activation of the C-C stretching mode in the phenyl and naphthalene ring provide evidence for the charge transfer interaction between the donor and acceptor groups and is responsible for its bioactivity as a fungicide. © 2011 Elsevier B.V. All rights reserved. Source

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