Nesamony Memorial Christian College

Marthandam, India

Nesamony Memorial Christian College

Marthandam, India
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Jeena Pearl A.,Scott Christian College Autonomous | Abbs Fen Reji T.F.,Nesamony Memorial Christian College
Journal of Chemical and Pharmaceutical Research | Year: 2013

Metal complexes of Schiff base (L) ligand, prepared via condensation of 4-chlorobenzaldehyde and 4-aminoantipyrine, are prepared. The ligand is characterized based on elemental analysis, mass, IR and NMR spectra. Metal complexes are reported and characterized based on elemental analyses, IR, electronic spectra, magnetic moment, molar conductance and cyclic voltammetry (CV). From the elemental analyses, 1: 2 [M]: [ligand] complexes are prepared with the general formulae [M(L2)Cl2] (M = Co(II), Ni(II), Cu(II), Zn(II) and Cd(II)). The IR results demonstrate that the co-ordination sites are the azomethine nitrogen and carbonyl oxygen atoms. The electronic spectral and magnetic measurement data indicate that the complexes exhibit octahedral geometry around the metal center. The in vitro biological screening effects of the synthesized compounds were tested against various microbial species and the results show that the metal complexes are more biological active than the ligand. The DNA cleavage activity of the ligand and its complexes were assayed on pUC18 DNA using gel electrophoresis. The result shows that the Co(II) and Cu(II) complexes have completely cleaved the DNA.

Deepa A.R.,Loyola Institute of Technology | Sam Emmanuel W.R.M.,Nesamony Memorial Christian College
Concepts in Magnetic Resonance Part A: Bridging Education and Research | Year: 2016

Detection of brain tumor in Magnetic Resonance Imaging (MRI) is vital as it delivers data about unusual tissues which is essential for planning treatment. Automating this method is challenging due to the high variety in appearance of tumor tissue among dissimilar patients and in many circumstances, comparison between tumor and normal tissue. In this article, we presented a mixture model based segmentation and classification of brain MRI for tumor identification. The proposed robust mixture estimator combining trimming of the outliers is based on component wise confidence level ordering of observations. The proposed method consists of three stages. In the first stage, the brain MRI is segmented into white matter (WM), gray matter (GM), Cerebrospinal fluid (CSF), and outliers by ordering of observations. In second stage, outliers consists of tumor cells in which eight type of features Contrast, Correlation, Homogeneity, Energy, Entropy, Standard deviation, Skewness, and Kurtosis are extracted. In the third stage, the extracted features are trained by Artificial Neural Network (ANN)and based on this a brain tumor identification scheme is established to examine those features to judge whether brain tumor is present in the given image or not. Experimental results indicate that the proposed classification method has achieved 93.47% in sensitivity, 100% in specificity, and 96.34% accuracy with less computational time based on the number of extracted features when compared to earlier classification methods. © 2017 Wiley Periodicals, Inc.

Reji A.F.,Nesamony Memorial Christian College
Journal of Chemical and Pharmaceutical Research | Year: 2013

Sesbania grandiflora Linn. (Family: Fabaceae) is widespread distributed in West Bengal, Assam, Karnataka and North-Eastern parts. The present study intended with various phytochemical screening and toxicity studies on Sesbania grandiflora. The present study was done with the help of soxhlet extraction, Kirby Bauer well diffusion assay, Minimum Inhibitory concentration assay (MIC) and Colony forming unit (CFU). Preliminary phytochemical evaluation of the aqueous extracts revealed that presence of carbohydrate, proteins, flavonoids, alkaloids, tannins and glycosides. As per the antimicrobial investigations in the presence study the CLP (Crude Leaf Powder) of Sesbania grandiflora exhibited low level antibacterial activity but the NPL (Nanosized leaf powder) exhibited highest level of antibacterial activity.

Sheeja B.,Government of Tamilnadu | Sindhu D.,Nesamony Memorial Christian College | Ebanasar J.,Government of Tamilnadu
Asian Pacific Journal of Tropical Disease | Year: 2012

Objective: The purpose of the present study was to assess the acetone and ethanol extracts of Andrographis paniculata against the filarial vector Culex quinquefasciatus. Methods: The ethanol and acetone extracts of plant leaves was used at 25, 50, 100, 200 and 300 ppm dilution in bioassays against second instar larvae of Culex quinquefasciatus. Ten larvae were exposed to the leaf extract at different concentration in a final volume of 100 mL formulation taken in 500 mL of glass bowl. For avoiding error triplicates were maintained. Tap water was taken as control. The larval mortality at different concentrations and in control was recorded 24 hour continuous exposure. Results: The toxicity of ethanol extract of Andrographis paniculata on survival of Culex quinquefasciatus reveals that the mortality is dependent on the dose of the plant extract and also on time of exposure. Highest mortality rate of 20% and 73.3% was recorded in 300 ppm at 3 and 24 h respectively. The similar trend was observed in case of the toxicity of acetone extract. Conclusions: The results of the present study suggest that the leaf extracts of Andrographis paniculata may have the potential to be used as an ideal eco-friendly approach for the control of the filarial vector Culex quinquefasciatus. © 2012 Asian Pacific Tropical Medicine Press.

Dhas D.A.,Nesamony Memorial Christian College | Joe I.H.,Center for Molecular and Biophysics Research | Roy S.D.D.,Nesamony Memorial Christian College | Balachandran S.,Mg College
Materials Today: Proceedings | Year: 2015

Density functional theory and vibrational analysis of 3-alkyl-4-amino-6-aryl-1,2,4-triazin-5-one herbicide has been carried out. The geometry has been optimized by B3LYP level of theories using 6-311G (df, p) basis set using Gaussian 09 program and compared with the crystal data. NBO and structural analysis has been carried out on the compound. Theoretical methods have been used to study the proper and improper hydrogen bonds, considering the hydrogen bond length and charge transfer. The Mulliken population analysis on atomic charges and the HOMO-LUMO energy were also calculated. © 2015 Elsevier Ltd.

Dhas D.A.,Center for Molecular and Biophysics Research | Dhas D.A.,Nesamony Memorial Christian College | Joe I.H.,Center for Molecular and Biophysics Research | Roy S.D.D.,Nesamony Memorial Christian College | Freeda T.H.,St Hindu College
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2010

NIR FT-Raman and IR spectra of the biologically active molecule, chlorothalonil have been recorded and analyzed. The molecular geometry and vibrational wavenumbers of the title compound in the ground state have been calculated by density functional theory (DFT) with 6-31G(d) basis set. In order to obtain the information about the influence of intramolecular interaction on the molecule, the calculated geometries of chlorothalonil molecule was compared with the experimental data. The results of the optimized molecular structure gave clear evidence for the intramolecular charge transfer (ICT). Time-dependent density functional theory (TD-DFT) calculation of the electronic spectra has been performed and compared with the experimental UV-visible spectrum. Mulliken's net charges have been calculated and compared with the atomic natural charges. The effects of chlorine and cyanide group substituent in benzene ring in the vibrational wavenumbers have been analyzed. NBO analysis is useful to understand the intramolecular hyperconjugative interaction between lone pair Cl and σ*(C-C) bond orbital. © 2010 Elsevier B.V.

Arul Dhas D.,Nesamony Memorial Christian College | Hubert Joe I.,Center for Molecular and Biophysics Research | Roy S.D.D.,Nesamony Memorial Christian College | Balachandran S.,Mg College
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2011

Vibrational analysis of the thionocarbamate fungicide tolnaftate which is antidermatophytic, antitrichophytic and antimycotic agent, primarily inhibits the ergosterol biosynthesis in the fungus, was carried out using NIR FT-Raman and FTIR spectroscopic techniques. The equilibrium geometry, various bonding features, harmonic vibrational wavenumbers and torsional potential energy surface (PES) scan studies have been computed using density functional theory method. The detailed interpretation of the vibrational spectra has been carried out with the aid of VEDA.4 program. Vibrational spectra, natural bonding orbital (NBO) analysis and optimized molecular structure show the clear evidence for electronic interaction of thionocarbamate group with aromatic ring. Predicted electronic absorption spectrum from TD-DFT calculation has been compared with the UV-vis spectrum. The Mulliken population analysis on atomic charges and the HOMO-LUMO energy were also calculated. Vibrational analysis reveals that the simultaneous IR and Raman activation of the C-C stretching mode in the phenyl and naphthalene ring provide evidence for the charge transfer interaction between the donor and acceptor groups and is responsible for its bioactivity as a fungicide. © 2011 Elsevier B.V. All rights reserved.

Emmanuel W.R.S.,Nesamony Memorial Christian College | Revina I.M.,Nesamony Memorial Christian College
2015 International Conference on Control Instrumentation Communication and Computational Technologies, ICCICCT 2015 | Year: 2015

Recognizing the human facial expression and emotion by computer is an interesting and challenging problem. This project proposes a method for facial expression recognition (FER) using Local Directional Number Pattern (LDN) and Local Tetra Pattern (LTrP). The proposed FER method removes the noise using Modified Decision Based Unsymmetrical Median Filter (MDBUTMF) method. The Local Directional Number (LDN) pattern descriptor is found based on the eight Gaussian edge descriptors. The proposed method encodes the relationship between the referenced pixel and its neighbors, based on the directions that are calculated using the first-order derivatives in vertical and horizontal directions. The training poses such as disgust, sad, smile and surprise are undergone the Gaussian mask generation, Gaussian edge detection, LDN process, LTrP process, MLDN histogram and LTrP histogram process. These training histograms are used to train up the facial expressions using Support Vector Machine (SVM). The SVM classifier classifies the facial expressions into disgust, sad, smile and surprise. The proposed method increases the FER accuracy at a significant level. The proposed method is a suitable one for any facial expression recognition needs. © 2015 IEEE.

Sukumaran S.,Nesamony Memorial Christian College | Raj A.D.S.,Scott Christian College
Indian Journal of Traditional Knowledge | Year: 2010

An attempt has been made to identify folklore medicinally important plants frequently used by rural communities of sacred groves and it environs of Kanyakumari district, Tamil Nadu. A total of 34 medicinal plants from 33 genera under 29 families were enumerated. Most of the plants are used for curing earache, skin diseases, fever, cold, headache, cough, urinary disorder, ulcer, etc. Of 29 families, 26 families were nonspecific. Plants of Rutaceae was largely represented (4 species), followed by Euphorbiaceae and Sapindaceae.

Rejia T.F.A.F.,Nesamony Memorial Christian College | Rajasekharan K.N.,Kerala University
Journal of Heterocyclic Chemistry | Year: 2010

(Chemical Equation Presented) The synthesis of 2-(4-amino-2- alkylaminothiazol-5-oyl)benzothiazoles and 2-[2,4-bis(arylamino)thiazol-5-oyl] benzothiazoles as benzothiazoloylthiazole analogs of the cytotoxic marine alkaloid dendrodoine is reported. The highly decorated thiazole ring assembly was achieved using 2-bromoacetybenzothiazole to supply the C5 ring carbon and amidinothioureas of the type R1NH-CS-NH-C(=NHR2)-(NHR 3) to provide the four ring atoms [C4-N3-C2-S1] in a [4+1] thiazole ring construction strategy. The antibacterial activity of these new analogs is reported. © 2010 HeteroCorporation.

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