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Chūō-ku, Japan

Tanaka S.,Hokkaido University | Koizumi S.-I.,Hokkaido University | Makiuchi N.,Hokkaido University | Aoyagi Y.,Hokkaido University | And 7 more authors.
Cellular Immunology | Year: 2011

During the search for immuno-improving foods, we found that a variety of the Japanese soybean, Glycine max cv. Kurosengoku (Kurosengoku), which activated Type-1 immunity in a Toll-like receptor (TLR)4- and TLR2-dependent manner. Namely, the extract of Kurosengoku first caused production of IL-12 from DC and sequentially induced IFN-γ production by NK1.1+ NK cells and NKT cells. The IFN-γ production was significantly blocked by neutralizing mAb against IL-12 or TLR4- and TLR2-deficient condition, indicating that TLR4- and TLR2-dependent activation of DC to produce IL-12 was essential for the production of IFN-γ from spleen cells by Kurosengoku. Moreover, the extract of Kurosengoku also enhanced production of IFN-γ from human PBMC by co-stimulation with anti-CD3 mAb in a TLR2- and TLR4-dependent manner. Thus, our findings strongly suggest that Kurosengoku might a novel immuno-improving food, which would be a useful tool for preventing the tip of immune balance in developed countries. © 2010 Elsevier Inc.

Tanaka S.,Hokkaido University | Koizumi S.-I.,Hokkaido University | Masuko K.,Hokkaido University | Makiuchi N.,Hokkaido University | And 9 more authors.
International Immunopharmacology | Year: 2011

Type-1 immunity has an essential role for our host defenses against cancer and outer pathogens such as bacteria and virus. We demonstrated here that the edible plant extract of Chrysanthemum coronarium L. (C. coronarium) remarkably activates Type-1 immunity in a Toll-like receptor (TLR)2-, TLR4-, and TLR9-dependent manner. In the present experiments, the extract of C. coronarium significantly induces interferon (IFN)-γ production by mouse spleen cells. In addition, the IFN-γ production by spleen cells was completely blocked by the addition of anti-Interleukin (IL)-12 monoclonal antibodies. We confirmed that NK1.1 + natural killer (NK) cells, NKT cells, and CD11c + dendritic cells (DC) were immediately activated after the stimulation with the extract of C. coronarium and the IFN-γ production was abolished in NK1.1 + cell-depleted spleen cells. The stimulation with the extract of C. coronarium caused DC maturation involving with up-regulations of surface expression levels of MHC class I, MHC class II, CD40, and CD86 as well as induction of IL-12 production. The IFN-γ production induced by the extract was significantly reduced in the spleen cells depleted CD11c + cells. Furthermore, the IFN-γ production after the stimulation was strongly reduced in TLR4- and partially in TLR2- and TLR9-deficient spleen cells. Thus, we demonstrated the cellular mechanism for the activation of Type-1 immunity via NK cells, NKT cells, and DC by the extract of C. coronarium. These findings strongly suggest that C. coronarium would be a promising immuno-improving adjuvant, which might be useful for prevention of infectious, cancer, and allergic diseases through the activation of Type-1 immunity. © 2010 Elsevier B.V. All rights reserved.

Nepuree Corporation | Date: 2016-03-08

Liquefied or solid processed foods made of vegetables and fruits, namely, processed vegetables and food; puree form processed foods made of vegetables, namely, processed vegetables; puree form processed foods made of fruits, namely, processed fruits; vegetables puree; fruits puree; processed vegetables and fruits; frozen vegetables; frozen fruits; edible oils and fat; milk products, excluding ice cream, ice milk and frozen yogurt; beans, preserved; boiled beans; tofu; fermented soybeans, namely, natto; fried tofu pieces, namely, abura-age; freeze-dried tofu pieces, namely, kohri-dofu; jelly made from devils tongue root, namely, konnyaku; soya milk being a milk substitute; mixes for making soup; side-dish made of fermented soybean, namely, name-mono; protein for human consumption, namely, formed textured vegetable protein for use as a meat substitute. Tea; coffee; cocoa; confectionery made of sugar; starch-based Candies, namely, ame; ice cream; ice candies; bread and buns; sandwiches; steamed buns stuffed with minced meat, namely, Chinese-manjuh; hamburger sandwiches; pizzas; hot dog sandwiches; meat pies; seasonings other than spices; cereal preparations, namely, Farinaceous food pastes for human consumption, Soy bean paste, Rice paste; instant confectionery mixes, namely, cake mixes ; pasta sauce; husked rice; husked oats; husked barley; flour; soybean flour. Beers; carbonated beverages; fruits juices; vegetable juices being beverages; whey beverages. Japanese liquors in general; western liquors in general; alcoholic fruit beverages; Japanese shochu-based beverages, namely, chuhai; Chinese liquors in general; flavored tonic liquors.

Nepuree Corporation | Date: 2013-05-30

[Problem to be solved] To provide a method for operating a food mill and an automatic food milling apparatus suitable for various foodstuffs heated and softened using superheated vapor are milled by passing the foodstuffs through a strainer while maximally suppressing destruction of cells of the foodstuffs, to continuously manufacture puree with original colors, odors, tastes, and nutritional values kept unchanged. [Solution] A rotation speed difference between a upper mortar and a lower mortar is used to crush and ground ingredient foodstuffs by a shearing force between the upper mortar and the lower mortar, and a conical recessed surface of the lower mortar is utilized to separate the crushed ingredient foodstuffs into filtered foodstuffs and residues by a centrifugal force resulting from rotation of the lower mortar so that the filtered foodstuffs and the residues are collected in a filtered foodstuff collection unit and a residue collection unit, respectively.

Murakami A.,Kyoto University | Nesumi A.,Japan National Agriculture and Food Research Organization | Maeda-Yamamoto M.,Japan National Agriculture and Food Research Organization | Yamaguchi H.,Nepuree Corporation | And 4 more authors.
Journal of Food and Drug Analysis | Year: 2015

Sunrouge is an anthocyanin-rich, new tea cultivar that contains similar levels of catechins as Yabukita, the most popular tea cultivar consumed in Japan. Interestingly, Sunrouge preparations have previously been shown to have more pronounced acetylcholinesterase inhibitory and anticolitis activities than those of Yabukita. In this study, we examined their effects on expressions of self-defensive molecules, including heat shock proteins (HSPs), which are molecular chaperones involved in homeostasis and longevity. Hot water extract from freeze-dried Sunrouge significantly upregulated messenger RNA (mRNA) expressions of HSP40, HSP70, and HSP32 (heme oxygenase-1), with grades greater than those shown by Yabukita. Oral administration of freeze-dried preparation of Sunrouge to male ICR mice at a dose of 1% in the basal diet for 1 month resulted in marked upregulations of several HSP mRNA expressions in mucosa from the gastrointestinal tract, especially the upper small intestine. Again, its efficacy was remarkably higher than that of Yabukita. Moreover, exposure of Caenorhabditis elegans to Sunrouge conferred thermoresistant phenotype, and also resulted in a significant life-span elongation. Taken together, our results suggest that Sunrouge is a unique and promising tea cultivar for regulating self-defense systems. © 2015, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. All rights reserved.

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