Nepuree Corporation

Chūō-ku, Japan

Nepuree Corporation

Chūō-ku, Japan
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Tanaka S.,Hokkaido University | Koizumi S.-I.,Hokkaido University | Makiuchi N.,Hokkaido University | Aoyagi Y.,Hokkaido University | And 7 more authors.
Cellular Immunology | Year: 2011

During the search for immuno-improving foods, we found that a variety of the Japanese soybean, Glycine max cv. Kurosengoku (Kurosengoku), which activated Type-1 immunity in a Toll-like receptor (TLR)4- and TLR2-dependent manner. Namely, the extract of Kurosengoku first caused production of IL-12 from DC and sequentially induced IFN-γ production by NK1.1+ NK cells and NKT cells. The IFN-γ production was significantly blocked by neutralizing mAb against IL-12 or TLR4- and TLR2-deficient condition, indicating that TLR4- and TLR2-dependent activation of DC to produce IL-12 was essential for the production of IFN-γ from spleen cells by Kurosengoku. Moreover, the extract of Kurosengoku also enhanced production of IFN-γ from human PBMC by co-stimulation with anti-CD3 mAb in a TLR2- and TLR4-dependent manner. Thus, our findings strongly suggest that Kurosengoku might a novel immuno-improving food, which would be a useful tool for preventing the tip of immune balance in developed countries. © 2010 Elsevier Inc.


Tanaka S.,Hokkaido University | Koizumi S.-I.,Hokkaido University | Masuko K.,Hokkaido University | Makiuchi N.,Hokkaido University | And 9 more authors.
International Immunopharmacology | Year: 2011

Type-1 immunity has an essential role for our host defenses against cancer and outer pathogens such as bacteria and virus. We demonstrated here that the edible plant extract of Chrysanthemum coronarium L. (C. coronarium) remarkably activates Type-1 immunity in a Toll-like receptor (TLR)2-, TLR4-, and TLR9-dependent manner. In the present experiments, the extract of C. coronarium significantly induces interferon (IFN)-γ production by mouse spleen cells. In addition, the IFN-γ production by spleen cells was completely blocked by the addition of anti-Interleukin (IL)-12 monoclonal antibodies. We confirmed that NK1.1 + natural killer (NK) cells, NKT cells, and CD11c + dendritic cells (DC) were immediately activated after the stimulation with the extract of C. coronarium and the IFN-γ production was abolished in NK1.1 + cell-depleted spleen cells. The stimulation with the extract of C. coronarium caused DC maturation involving with up-regulations of surface expression levels of MHC class I, MHC class II, CD40, and CD86 as well as induction of IL-12 production. The IFN-γ production induced by the extract was significantly reduced in the spleen cells depleted CD11c + cells. Furthermore, the IFN-γ production after the stimulation was strongly reduced in TLR4- and partially in TLR2- and TLR9-deficient spleen cells. Thus, we demonstrated the cellular mechanism for the activation of Type-1 immunity via NK cells, NKT cells, and DC by the extract of C. coronarium. These findings strongly suggest that C. coronarium would be a promising immuno-improving adjuvant, which might be useful for prevention of infectious, cancer, and allergic diseases through the activation of Type-1 immunity. © 2010 Elsevier B.V. All rights reserved.


Patent
Nepuree Corporation | Date: 2016-09-07

To provide a method for operating a strainer that uses a centrifugal force generated by the rotation of a bottomed cylindrical vessel (3) having filtering holes (3d) in a side surface and can eliminate the clogging of the filtering holes and maintain the optimal straining effect while maintaining the optimal pressure and duration of pressing food ingredients, and to further provide an automatic strainer device. Provided is a method for operating a strainer, the strainer including: a vertical, bottomed cylindrical vessel that is supported so as to be rotatable around a central axis and has filtering holes bored in a circumferential plate; rotary pressers (24, 25) that are located inside the bottomed cylindrical vessel and supported so as to be rotatable around the central axis while being in contact with or closer to an inner circumferential surface of the circumferential plate; and a filtrate catching member that catches a filtrate discharged through the filtering holes of the bottomed cylindrical vessel to the outside of the vessel, the method including the step of, while rotating the bottomed cylindrical vessel, which contains an object to be strained input therein, in a predetermined rotation direction at a first rotation speed, rotating the rotary pressers in the same rotation direction as the bottomed cylindrical vessel at a second rotation speed different from the first rotation speed by a predetermined speed difference.


Patent
Nepuree Corporation | Date: 2013-05-30

[Problem to be solved] To provide a method for operating a food mill and an automatic food milling apparatus suitable for various foodstuffs heated and softened using superheated vapor are milled by passing the foodstuffs through a strainer while maximally suppressing destruction of cells of the foodstuffs, to continuously manufacture puree with original colors, odors, tastes, and nutritional values kept unchanged. [Solution] A rotation speed difference between a upper mortar and a lower mortar is used to crush and ground ingredient foodstuffs by a shearing force between the upper mortar and the lower mortar, and a conical recessed surface of the lower mortar is utilized to separate the crushed ingredient foodstuffs into filtered foodstuffs and residues by a centrifugal force resulting from rotation of the lower mortar so that the filtered foodstuffs and the residues are collected in a filtered foodstuff collection unit and a residue collection unit, respectively.


Patent
Hokkaido University and Nepuree Corporation | Date: 2011-05-11

Disclosed is a novel natural material having an immune balance-regulating activity. Specifically disclosed is an immune balance regulator comprising small glossy black soybean (a bean belonging to the genus Glycinemax), a crushed product of the bean, or an extract of the bean or the crushed product with an aqueous ethanol solution as an active ingredient. The immune balance regulator can activate an immunocyte essential for biophylaxis, particularly an antigen-presenting cell, to activate an immune function. The immune balance regulator can also suppress excess Th2 immunological ability so as to keep a good balance between Th1 immunological ability and Th2 immunological ability, thereby enhancing an immunological biophylaxis function and inhibiting an undesirable allergic reaction.


Trademark
Nepuree Corporation | Date: 2016-03-08

Liquefied or solid processed foods made of vegetables and fruits, namely, processed vegetables and food; puree form processed foods made of vegetables, namely, processed vegetables; puree form processed foods made of fruits, namely, processed fruits; vegetables puree; fruits puree; processed vegetables and fruits; frozen vegetables; frozen fruits; edible oils and fat; milk products, excluding ice cream, ice milk and frozen yogurt; beans, preserved; boiled beans; tofu; fermented soybeans, namely, natto; fried tofu pieces, namely, abura-age; freeze-dried tofu pieces, namely, kohri-dofu; jelly made from devils tongue root, namely, konnyaku; soya milk being a milk substitute; mixes for making soup; side-dish made of fermented soybean, namely, name-mono; protein for human consumption, namely, formed textured vegetable protein for use as a meat substitute. Tea; coffee; cocoa; confectionery made of sugar; starch-based Candies, namely, ame; ice cream; ice candies; bread and buns; sandwiches; steamed buns stuffed with minced meat, namely, Chinese-manjuh; hamburger sandwiches; pizzas; hot dog sandwiches; meat pies; seasonings other than spices; cereal preparations, namely, Farinaceous food pastes for human consumption, Soy bean paste, Rice paste; instant confectionery mixes, namely, cake mixes ; pasta sauce; husked rice; husked oats; husked barley; flour; soybean flour. Beers; carbonated beverages; fruits juices; vegetable juices being beverages; whey beverages. Japanese liquors in general; western liquors in general; alcoholic fruit beverages; Japanese shochu-based beverages, namely, chuhai; Chinese liquors in general; flavored tonic liquors.


Patent
Nepuree Corporation | Date: 2014-10-29

A strainer device that collects a filtered object even when the strainer device is used with an object to be strained that is low in water content and highly adhesive, via softening by heating in superheated steam. The strainer device has an inner surface that is circular in cross section, surrounds a strainer vessel, and is supported so as to be rotatable about a central axis thereof; a scraping member that is disposed at a predetermined position along the inner surface of the cover body and scrapes the filtered object adhering to the inner surface when the cover body is rotating; the strainer vessel and the cover body rotate. When the strainer vessel is rotating, the filtered object pushes out of the filtering hole and adhers to the inner surface of the cylindrical cover body and is scraped off at the predetermined position on a circumference along the inner surface.


Patent
Nepuree Corporation | Date: 2014-10-29

Operating a strainer using centrifugal force generated by the rotation of a bottomed cylindrical vessel having filtering holes in a side surface. The strainer can eliminate the clogging of the filtering holes and maintain the optimal straining effect while maintaining the optimal pressure and duration of pressing food ingredients. The strainer catches a filtrate discharged through the filtering holes of the bottomed cylindrical vessel to the outside of the vessel while rotating the bottomed cylindrical vessel, which contains an object to be strained input therein, in a predetermined rotation direction at a first rotation speed, rotating the rotary pressers in the same rotation direction as the bottomed cylindrical vessel at a second rotation speed different from the first rotation speed of the bottomed cylindrical vessel by a predetermined speed difference.


Patent
Nepuree Corporation | Date: 2015-06-03

[Problem to be solved] To provide a method for operating a food mill and an automatic food milling apparatus suitable for various foodstuffs heated and softened using superheated vapor are milled by passing the foodstuffs through a strainer while maximally suppressing destruction of cells of the foodstuffs, to continuously manufacture puree with original colors, odors, tastes, and nutritional values kept unchanged. [Solution] A rotation speed difference between a upper mortar and a lower mortar is used to crush and ground ingredient foodstuffs by a shearing force between the upper mortar and the lower mortar, and a conical recessed surface of the lower mortar is utilized to separate the crushed ingredient foodstuffs into filtered foodstuffs and residues by a centrifugal force resulting from rotation of the lower mortar so that the filtered foodstuffs and the residues are collected in a filtered foodstuff collection unit and a residue collection unit, respectively.


Patent
Nepuree Corporation | Date: 2016-09-07

To provide a strainer device that can collect a filtered object without problems even if the strainer device is used with an object to be strained that is low in water content and is highly adhesive, such as sweet potato softened by heating in superheated steam. The strainer device includes: a cover body (26) that is in a vertical orientation, has an inner surface that is circular in cross section, surrounds a strainer vessel (3) at an appropriate distance and is supported so as to be rotatable about a central axis thereof; a scraping member (22) that is disposed at a predetermined position along the inner surface of the cover body and scrapes a filtered object adhering to the inner surface when the cover body is rotating; and a rotationally driving mechanism that makes the strainer vessel and the cover body rotate, and, when the strainer vessel is rotating, the filtered object pushed out of the filtering hole (3d) and adhering to the inner surface of the cylindrical cover body is scraped off to the predetermined position on a circumference along the inner surface.

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