Nepalgunj Medical College

Kohalpur, Nepal

Nepalgunj Medical College

Kohalpur, Nepal
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Mishra A.,Nepalgunj Medical College | Pandey A.,Nepalgunj Medical College | Mishra S.C.,University of Lucknow
Journal of Laryngology and Otology | Year: 2017

Background:: Molecular categorisation may explain the wide variation in the clinical characteristics of juvenile nasopharyngeal angiofibroma. Methods:: Variations in molecular markers in juvenile nasopharyngeal angiofibroma in an Indian population were investigated and compared with global reports. Results:: Variable molecular marker expression was demonstrated at the regional and global levels. A wide variation in molecular characteristics is evident. Molecular data have been reported for only 11 countries, indicating a clear geographical bias. Only 58 markers have been studied, and most are yet to be validated. Conclusion:: Research into the molecular epidemiology of juvenile nasopharyngeal angiofibroma is still in its infancy. Although the molecular variation is not well understood, data obtained so far have prompted important research questions. Hence, multicentre collaborative molecular studies are needed to establish the aetiopathogenesis and establish molecular surrogates for clinical characteristics. Copyright © JLO (1984) Limited 2017


Thanpari C.,Nepalgunj Medical College | Koner B.C.,Maulana Azad Medical College
Asian Pacific Journal of Cancer Prevention | Year: 2012

Objective: The study was conducted to assess biochemical profiles in premenopausal and postmenopausal women having breast cancer. Materials and Methods: A hospital based case control study was carried out at Manipal Teaching Hospital (MTH), Pokhara, Nepal. The analysed variables were age, metabolic profile including total cholesterol, triglycerides, HDL-C, LDL-C, blood sugar, insulin concentration, C-peptide, HbA1c and selenium. Descriptive statistics and testing of hypothesis were used for the analysis using EPI INFO and SPSS 16 software. Results: In premenopausal women, significant differences were noted for total cholesterol (P value <0.001), triglycerides (P value 0.002), HbA1c level (P value <0.001), insulin concentration (P value 0.030), C-peptide concentration (P value 0.001), and selenium (P value <0.001) between cases and controls. Insignificant results were found for HDL-C (P value 0.749), LDL-C (P value 0.933), blood sugar (P value 0.59) and BMI (P value 0.746). Similarly, significant difference in total cholesterol (P value <0.001), triglycerides (P value 0.001), LDL-C (P value <0.001), HDL-C (P value 0.025), blood sugar (P value <0.001), insulin concentration (P value <0.001), c-peptide concentration (P value <0.001), HbA1c level (P value <0.001) and selenium (P value <0.001) were observed for postmenopausal patients and controls. Conclusions: Assessing metabolic changes and their management may be important for control of breast cancer and increased survival.


Goit R.K.,Nepalgunj Medical College | Paudel B.H.,B P Koirala Institute of Health science | Khadka R.,B P Koirala Institute of Health science | Roy R.K.,Nepalgunj Medical College | Shrewastwa M.K.,Nepalgunj Medical College
Journal of Diabetes Investigation | Year: 2014

Aims/Introduction: The aim of the present study was to determine the effect of moderate aerobic exercise on cardiac autonomic function in type 2 diabetic patients. Materials and Methods: Heart rate variability of 20 patients with type 2 diabetes was assessed. Resting electrocardiogram for the heart rate variability analysis at spontaneous respiration was recorded for 5 min in the supine position before and after 6 months of supervised aerobic training given three times per week. Results: In time domain measures, the square root of the mean of the sum of the squares of differences between adjacent R-R intervals (RMSSD; 29.7 [26-34.5] vs 46.4 [29.8-52.2] ms, P = 0.023) and the percentage of consecutive RR intervals that differ by more than 50 ms (pNN50; 10.7 [5.5-12.7] vs 26.1 [6.6-37.2]%, P = 0.025] were significantly increased after exercise. In frequency domain measures, low frequency (62.4 [59.1-79.2] vs 37 [31.3-43.3] nu, P = 0.003) and low frequency/high frequency (1.67 [1.44-3.8] vs 0.58 [0.46-0.59]%, P = 0.009) were significantly decreased, whereas high frequency (95 [67-149] vs 229 [98-427] ms2, P = 0.006) and high frequency (37.6 [20.8-40.9] vs 63 [56.7-68.7] normalized units, P = 0.003) were significantly increased after exercise. In a Poincaré plot, standard deviation perpendicular to the line of the Poincaré plot (SD1; 21.3 [18.5-24.8]-33.1 [21.5-37.2] ms, P = 0.027) was significantly increased after exercise. Conclusions: These data suggest that three times per week moderate intensity aerobic exercise for 6 months improves cardiac rhythm regulation as measured by heart rate variability in type 2 diabetic patients. © 2014 The Authors.


Goit R.K.,Nepalgunj Medical College | Khadka R.,B P Koirala Institute of Health science | Sharma S.K.,B P Koirala Institute of Health science | Limbu N.,B P Koirala Institute of Health science | Paudel B.H.,B P Koirala Institute of Health science
Journal of Diabetes and its Complications | Year: 2012

Objective: The aim of this study was to compare cardiovascular autonomic function tests (AFT) and vibration perception threshold (VPT) of patients with type 2 diabetes mellitus (T2DM) with controls. Research Design/Methods: The study was conducted on 60 diabetic patients comparing with 30 controls. The cardiovascular AFT and VPT were assessed in both groups. Results: Among cardiovascular AFT, E:I ratio [1.24 (1.2-1.32) vs 1.3 (1.24-1.4), p = 0.001], and Valsalva ratio [1.28 (1.22-1.4) vs 1.6 (1.5-1.73), p = 0.001], the indicators of parasympathetic reactivity were reduced in T2DM. Rise in DBP during handgrip, an indicator of sympathetic reactivity was lower in T2DM [12 (10-14) vs 16 (14-18) mmHg, p = 0.001] whereas, fall in SBP during head up tilt [4 (4-8) vs 5 (4-8) mmHg] was comparable. VPT (somatic sensation) was comparable between T2DM and control. Conclusion: Autonomic involvement is more marked than somatic, and parasympathetic involvement is more marked than the sympathetic, possibly reflecting severity and chronological pattern of their involvement. © 2012 Elsevier Inc. All rights reserved.


Goit R.K.,Nepalgunj Medical College | Ansari A.H.,Birat Medical College
Indian Heart Journal | Year: 2016

Aim: The aim of the study was to compare heart rate variability (HRV) of newly diagnosed essential hypertensive subjects with controls. Methods: The study was conducted on 120 hypertensive subjects and 120 controls. Results: The time-domain measures, standard deviation of all RR intervals (SDNN), the square root of the mean of the sum of the squares of differences between adjacent RR intervals (RMSSD), and percentage of consecutive RR intervals that differ by more than 50ms (pNN50) that reflect parasympathetic activity were significantly less in hypertensive subjects. In frequency-domain measures, high frequency [HF (ms2)] and [HF (nu)], which reflects parasympathetic activity, was significantly less in hypertensive subjects while LF (nu) and LF/HF (%), which reflect sympathetic activity, were comparable between the groups. Conclusion: These findings suggest that HRV is reduced in subjects with newly diagnosed essential hypertension and the parasympathetic dysregulation is present in the early stage of essential hypertension. © 2015 Cardiological Society of India.


Mishra A.,University of Lucknow | Mishra S.C.,University of Lucknow | Mishra S.C.,Nepalgunj Medical College
European Archives of Oto-Rhino-Laryngology | Year: 2016

This report describes the third case of a true bilateral Juvenile nasopharyngeal angiofibroma (JNA), i.e. two separate JNA arising from both sides simultaneously. The associated multiple recurrences in such a case have not yet been reported. A 21-year-man underwent transpalatal excision and recurred twice. The last ‘neo-occurrence’ encountered after 2 years was at a different site and was subsequently managed by post-embolization endoscopic resection. A complete report of its clinico-radiological features and management outcome is discussed. © 2016 Springer-Verlag Berlin Heidelberg


Satyam S.M.,Manipal University India | Bairy L.K.,Manipal University India | Pirasanthan R.,Nepalgunj Medical College
Journal of Clinical and Diagnostic Research | Year: 2014

Background: Zincovit tablet is combination of grape seed extract and zinc containing multivitamin-mineral nutritional food supplement.Aims: To investigate the influence of single combined formulation of grape seed extract and zinc containing multivitamin-mineral nutritional food supplement tablets (Zincovit) on lipid profile in normal and diet-induced hypercholesterolemic rats.Materials and Methods: Anti-hyperlipidemic activity of combined formulation of grape seed extract and Zincovit tablets doses ranged from 40 to 160 mg/kg, p.o. was evaluated in normal and diet-induced hypercholesterolemic rats.Results: Hypercholesterolemic animals treated with combined formulation of grape seed extract and Zincovit tablets (nutritional food supplement) at 40, 80 and 160 mg/kg exhibited drastic decrease in serum triglycerides, total cholesterol, LDL-C, VLDL-C and rise of HDL-C in comparison to hypercholesterolemic control group animals. The anti-hyperlipidemic effect of single combined formulation of grape seed extract and Zincovit tablet was comparable with the standard drug atorvastatin treated animals and the variations were statistically non-significant. There was no significant impact of combined formulation of grape seed extract and Zincovit tablets on lipid profile among normal animals in comparison with normal control group.Conclusion: The present study demonstrated that the single combined formulation of grape seed extract and Zincovit tablet is the potential functional nutritional food supplements that could offer a novel therapeutic opportunity against diet-induced hypercholesterolemia in Wistar rats. © 2014, Journal of Clinical and Diagnostic Research. All rights reserved.


Chauhan R.S.,Nepalgunj Medical College | Saxena R.K.,Nepalgunj Medical College | Varshey S.,Nepalgunj Medical College
Ear, Nose and Throat Journal | Year: 2011

In monitoring patients for drug-induced hearing loss, most audiometric evaluations are limited to the range of frequencies from 0.25 to 8 kHz. However, such testing would fail to detect ototoxicity in patients who have already experienced hearing loss in the ultrahigh frequencies from 10 to 20 kHz. Awareness of ultrahigh-frequency ototoxicity could lead to changes in a drug regimen to prevent further damage. We conducted a prospective study of 105 patients who were receiving a potentially ototoxic drug-either gentamicin, amikacin, or cisplatin-to assess the value of ultrahigh-frequency audiometry in detecting systemic drug-induced hearing loss. We found that expanding audiometry into the ultrahigh-frequency range led to the detection of a substantial number of cases of hearing loss that would have otherwise been missed. © 2011, Vendome Group, LLC.


Singh P.,Nepalgunj Medical College | Khan S.,Nepalgunj Medical College | Mittal R.K.,Nepalgunj Medical College
Bangladesh Journal of Medical Science | Year: 2014

Background:Diabetes mellitus (DM) is characterized by some specific complications including diabetic nephropathy. Urea & creatinine are useful parameters to diagnose the renal function, despite some limitations. Objective:Study aimed to analyze the effect of hyperglycemic condition on the renal function parameter like serum urea and serum creatinine. Methods: It was a cross sectional study. To determine the incidence of kidney dysfunction in type 2 diabetics in Nepalgunj medical college and Hospital, Nepalgunj, Nepal. Random blood samples were taken from 100 diabetic subjects and 100 non-diabetic controls between the period 1st February, 2012 to 31st January, 2013 for investigation of plasma glucose fasting(FPG), blood urea and serum creatinine. These biochemical parameters were determined by using a fully automated clinical chemistry analyzer. The comparison was done by using Student ‘t’ test. Results: Our findings showed that the level of blood urea (P<0.0128 Diabetic male and P=0.0082 Diabetic female) and serum creatinine (P<0.0001 Diabetic male and P0.0187 Diabetic female) were significantly higher in type 2 diabetics as compared to non-diabetics in both male and female. There was no significant difference between diabetic male and female. High serum creatinine level was seen in males than females. Conclusion: In our study there was an increase of blood urea level in type 2 DM. Good control of blood glucose level is absolute requirement to prevent progressive renal impairment. © 2014 Ibn Sina Trust. All rights reserved.


Thanpari C.,Nepalgunj Medical College
Mymensingh medical journal : MMJ | Year: 2014

To estimate liver function tests in patients with alcoholic fatty liver disease, alcoholic hepatitis and alcoholic cirrhosis and to compare the levels of enzymes between the groups. A hospital based case control study was carried out at Nepalgunj Medical College, Nepal from January 2013 to June 2013. A total of 150 alcoholic associated liver disorders patients aged between 20-70 years and 50 sex age matched normal healthy controls were taken to assess liver function tests (LFTs) by measuring Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), Gamma glutamyltranspeptidase (GGT) & Albumin. The mean±SD of liver function tests (LFTs) of patients of alcoholic fatty liver disease is highest followed by alcoholic hepatitis patients. All the 3 groups of alcoholic associated liver disorders patients when compared to normal healthy control subjects showed statistically significant increase in the levels of AST (p<0.000), ALT (p<0.000), ALP (p<0.006), GGT (p<0.000), & Albumin (p<0.000). Liver function tests values for alcoholic associated liver disorders patients when compared to the healthy control subjects was significantly altered.

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