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York, United Kingdom

Bubela T.,University of Alberta | McCabe C.,University of Alberta | Archibald P.,Loughborough University | Atkins H.,Ottawa Hospital Research Institute | And 8 more authors.
Regenerative Medicine | Year: 2015

Significant investments in regenerative medicine necessitate discussion to align evidentiary requirements and decision-making considerations from regulatory, health system payer and developer perspectives. Only with coordinated efforts will the potential of regenerative medicine be realized. We report on discussions from two workshops sponsored by NICE, University of Alberta, Cell Therapy Catapult and Centre for Commercialization of Regenerative Medicine. We discuss methods to support the assessment of value for regenerative medicine products and services and the synergies that exist between market authorization and reimbursement regulations and practices. We discuss the convergence in novel adaptive licensing practices that may promote the development and adoption of novel therapeutics that meet the needs of healthcare payers. © 2015 Tania Bubela. Source

NEOTHERIX Ltd | Date: 2012-10-03

A medical sampling device, a method of manufacturing the device, and methods of testing and diagnosis using the device; a sampling dressing comprising the device, a method of manufacturing the dressing, and a method of diagnosis using the dressing; and a therapy dressing comprising the device, a method of manufacturing the dressing, and a method of treatment using the dressing. The a sampling device comprises a biodegradable porous scaffold which in use lies in contact with tissue to be sampled and comprises a fluid, in particular a reversibly thermoswitchable gel.

MacKintosh S.B.,University of Swansea | MacKintosh S.B.,Royal Veterinary College | MacKintosh S.B.,Aberystwyth University | Serino L.P.,Neotherix Ltd | And 7 more authors.
Biofabrication | Year: 2015

Endometrial stromal and epithelial cell function is typically studied in vitro using standard twodimensional monocultures, but these cultures fail to reflect the complex three-dimensional (3D) architecture of tissue. A 3Dmodel of bovine endometrium that reflects the architectural arrangement of in vivo tissue would beneficially assist the study of tissue function. An electrospun polyglycolide (PGA) scaffold was selected to grow a 3Dmodel of primary bovine endometrial epithelial and stromal cells, that reflects the architecture of the endometrium for the study of pathophysiology. Electrospun scaffolds were seeded with stromal and epithelial cells, and growth was assessed using histological techniques. Prostaglandin E2 and prostaglandin F2α responsiveness of endometrial scaffold constructs was tested using oxytocin plus arachidonic acid (OT + AA) or lipopolysaccharide (LPS). Stromal and epithelial cells growing on the electrospun scaffold had an architectural arrangement that mimicked whole tissue, deposited fibronectin, had appropriate expression of vimentin and cytokeratin and were responsive toOT+ AA and LPS, as measured by prostaglandin accumulation. In conclusion, a functional 3D model of stromal and epithelial cells was developed using a PGA electrospun scaffold which may be used to study endometrial pathophysiology. © 2015 IOP Publishing Ltd. Source

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