Greifswald, Germany
Greifswald, Germany

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Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2010.2.4.2-1 | Award Amount: 7.98M | Year: 2010

According to the European Society of Cardiology there has been an increase in the life expectancy at the age of 65 of the European population from 15.0 to 17.0 years in the years since 1980. In the elderly, up to 50% of deaths are caused by cardiovascular diseases, the majority accounted for by coronary artery disease. The most effective treatment for obstructive coronary disease is percutaneous intervention with coronary stenting and fuelled by the increasing disease burden there has been a rapid increase in the number of percutaneous coronary intervention procedures in Europe from 184,000 in 1992 to 885,000 in 2004. If the rate of progression remains constant, the projected number of coronary intervention procedures per annum will be about 1.5 million by 2010, with a stenting rate of close to 100%. The principal safety issue with current coronary stenting procedures is late stent thrombosis which, with a case mortality rate approaching 50%, makes this problem a very significant European health issue. The PRESTIGE project will result in significant improvement in prediction and prevention of late stent thrombosis by providing novel strategies that causally impede incident events without increasing the overall risk of bleeding. These goals will be achieved by a multidisciplinary consortium formed by world-leading EU-based specialists covering the requisite scientific skills and experience. Since the first drug-eluting stent was introduced in 2002 the growth of this sector has been explosive. Forecasts predicted the potential for this market segment to exceed 4.6 billion by 2009. The economic impact of this very ambitious project will be to provide the European health industries with novel stent products and new imaging technologies to identify patients at-risk, as well as amended European treatment guidelines. The social impact will be, amongst others, a tremendous cost reduction for the public and private health insurance systems all over Europe.


Vorhaben T.,University of Greifswald | Bottcher D.,University of Greifswald | Jasinski D.,Neoplas GmbH | Menyes U.,Neoplas GmbH | And 4 more authors.
ChemCatChem | Year: 2010

In this work, the immobilization of two hydrolases on plasma-modified polypropylene carriers was investigated. Treating Accurel MP1001 with an oxygen plasma was found most suitable to increase the hydrophilicity and to allow for efficient immobilization. Thus, for lipase B from Candida antarctica and for an esterase from Pyrobaculum calidifontis esterase (PestE) a 5-fold and 14-fold increase, respectively, in immobilization yield resulted compared to untreated carrier. In contrast to the oxygen-modified support, modification of the polypropylene carrier with ammonia plasma showed no positive effect. Furthermore, it could be shown that immobilized PestE catalyzed enantioselective transesterification of α-phenylethanol in vinyl acetate, whereas the free enzyme showed no activity. Both hydrolases could be recycled five times without significant loss of activity. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Mallin H.,University of Greifswald | Menyes U.,Enzymicals AG | Vorhaben T.,Neoplas GmbH | Hohne M.,University of Greifswald | Bornscheuer U.T.,University of Greifswald
ChemCatChem | Year: 2013

Two (R)-selective amine transaminases from Gibberella zeae (GibZea) and from Neosartorya fischeri (NeoFis) were immobilized on chitosan as a carrier to improve their application in the biocatalytic synthesis of chiral (R)-amines. An (S)-selective enzyme from Vibrio fluvialis (VfTA) was used for comparison. After improving the immobilization conditions, all enzymes could be efficiently immobilized. Additionally, the thermal stability of GibZea and NeoFis could be improved and also a slight shift of the pH optimum was observed for GibZea. All enzymes showed good activity in the conversion of α-methylbenzylamine. In the asymmetric synthesis of (R)-2-aminohexane from the corresponding ketone, a 13.4-fold higher conversion (>99%) was found for the immobilized GibZea compared to the free enzyme. Hence, the covalent binding with glutaraldehyde of these enzymes on chitosan beads resulted in a significant stabilization of the amine transaminases investigated. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Bussiahn R.,Leibniz Institute Fur Plasmaforschung Und Technology E.V. | Bussiahn R.,Neoplas GmbH | Lembke N.,Neoplas GmbH | Gesche R.,Ferdinand - Braun - Institute | And 2 more authors.
Hygiene + Medizin | Year: 2013

Physical plasmas applied to biological materials give cause for interdisciplinary research and open up new therapeutic options in medicine. Basic research aims for clarifying the interaction between plasma and living tissue or organisms. Direct therapeutic application in dentistry and dermatology like wound healing or treatment of skin diseases are of highest interest. This requires cold and tissue-tolerable plasma. In recent years, very different plasma source concepts had been developed and tested for their practicability. Their basic characterization in terms of electrical and thermal properties as well as spectral emission and production of chemical reactive species is a precondition for risk assessment and evaluation of possible fields of application. In the following, two examples of such plasma sources are introduced.


Kawai Y.,Kyushu University | Uchino K.,Kyushu University | Muta H.,Kyushu University | Kawai S.,Japan National Institute of Advanced Industrial Science and Technology | Rowf T.,Neoplas GmbH
Vacuum | Year: 2010

To develop ECR plasma source for industrial applications, we produced a large diameter ECR plasma and examined radial profiles of the ion saturation current as a function of pressure and power. It was found that ECR plasma uniform over 300 mm is produced for pressures higher than 1 mTorr and the electron temperature decreases with increasing pressures. © 2010 Elsevier Ltd. All rights reserved.


Patent
Leibniz Institute for Plasma Science, Technology and Neoplas Gmbh | Date: 2015-06-05

The invention relates to a device, preferably a collar, for treating areas of human or animal skin or mucous membrane with a cold atmospheric pressure plasma by creating a dielectrically hindered surface discharge, comprising at least one flexible insulating material (1), a flexible high-voltage electrode (2), a flexible dielectric (3), a flexible grounded electrode (4) and a gas supply (7), characterized in that the flexible high-voltage electrode (2) is embedded in the insulating elastomer (3), having the effect of a dielectric, and the grounded electrode (4) is applied to the elastomer surface facing the surface to be treated.


Patent
Neoplas Gmbh | Date: 2010-02-12

A method and a series of devices for dry cleaning, activating, modifying, coating, and biologically decontaminating (degerming, disinfecting, sterilizing) surfaces by means of an atmospheric pressure plasma generated using a surface barrier discharge are provided. The invention is used for dry cleaning, activating, coating, modifying, and biologically contaminating surfaces by means of an atmospheric pressure plasma generated in a defined, flowing gas atmosphere by a surface barrier discharge, comprising a high-voltage electrode that is covered with a dielectric or ferroelectric material, an electrically conducting grounded contact electrode, a high-voltage supply, a gas supply, and a gas nozzle (encompassing a gas outlet); said gas nozzle is located in the direct vicinity of the grounded contact electrode, is integrated into the contact electrode, or acts as the grounded contact electrode.


Patent
NEOPLAS GmbH, Leibniz Institute for Plasma Science and Technology | Date: 2010-07-27

The invention relates to a device, preferably a collar, for treating areas of human or animal skin or mucous membrane with a cold atmospheric pressure plasma by creating a dielectrically hindered surface discharge, comprising at least one flexible insulating material (1), a flexible high-voltage electrode (2), a flexible dielectric (3), a flexible grounded electrode (4) and a gas supply (7), characterized in that the flexible high-voltage electrode (2) is embedded in the insulating elastomer (3), having the effect of a dielectric, and the grounded electrode (4) is applied to the elastomer surface facing the surface to be treated.

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