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Bancalari M A.,Neonatology Unit | Schade Y R.,Hospital Guillermo Grant Benavente | Pena Z R.,University of Concepcion | Pavez P N.,University of Concepcion
Archivos Argentinos de Pediatria | Year: 2014

Ophthalmological outcomes in a series of children with retinopathy of prematurity (ROP) in the threshold stage treated with intravitreal bevacizumab are reported. Twelve very low birth weight (VLBW) preterm infants who were administered intravitreal bevacizumab as monotherapy for retinopathy of prematurity in the threshold stage and in whom standard laser photocoagulation therapy was contraindicated were evaluated. Ophthalmological examinations were carried out and response to treatment, second interventions, and complications were evaluated. The gestational age of these patients was 26.3 ± 1.8 weeks and their birth weight was 845 ± 153 g. A good response was observed in eight cases, while four patients required to be reintervened with laser photocoagulation. No immediate complications were detected and there were no deaths. Source

Bertini V.,Cytogenetics and Molecular Genetics Unit | Ghirri P.,Neonatology Unit | Bicocchi M.P.,Haematology and Oncology Laboratory | Simi P.,Cytogenetics and Molecular Genetics Unit | Valetto A.,Cytogenetics and Molecular Genetics Unit
Fertility and Sterility | Year: 2010

Objective: To characterize the breakpoints of a t(X;15) found in a woman with premature ovarian failure (POF). Design: Case report. Setting: Molecular and cytogenetics unit in a university-affiliated hospital. Patient(s): A 19-year-old infertile woman presenting with a normal female phenotype but primary amenorrhea. Intervention(s): Molecular cytogenetic analyses and genetic counseling. Main Outcome Measure(s): Translocation t(X;15) defined by fluorescence in situ hybridization (FISH) and array comparative genomic hybridization (array CGH). Result(s): Chromosome and FISH analysis revealed 46,XX, t(X;15)(Xq22.1;p11); the active X was translocated and had been inherited from her mother. Detailed molecular characterization by FISH showed that the NXF5 (nuclear RNA export factor 5) gene was contained in the clone spanning the breakpoint on the X chromosome. Conclusion(s): The NXF5 gene is an appealing candidate for POF because it shows functional homology with the FMR1 (fragile X mental retardation 1) gene. Further analyses of its expression as well as mutation screening in other POF patients will help to elucidate its role. © 2010 by American Society for Reproductive Medicine. Source

Bednarek N.,Neonatology Unit | Mathur A.,Washington University in St. Louis | Inder T.,Washington University in St. Louis | Wilkinson J.,Washington University in St. Louis | And 2 more authors.
Neurology | Year: 2012

Objective: The objective of this work was to determine the impact of therapeutic hypothermia (TH) on the magnitude and time course of mean diffusivity (MD) changes following hypoxic-ischemic encephalopathy (HIE) in newborns. Methods: Cerebral MRI scans of infants undergoing whole body TH for HIE from 2007 to 2010 were retrospectively reviewed. The data were analyzed identically to a control group of newborns with HIE previously published, prior to the development of TH. Anatomic injury was defined on T1-and T2-weighted ("late") MRI obtained after the fifth day of life. Since MD values vary regionally, the ratios of MD values for injured and normal tissue were calculated for areas of injury. Normal values were obtained from corresponding brain regions of 12 infants undergoing TH who had no injury on MRI studies. Results: Twenty-three of 59 infants who underwent TH and MRI displayed cerebral injury on late MRI and were included in the study. MD ratios were decreased in all injured infants within the first 7 days of life. The return of MD to normal (pseudonormalization) occurred after the tenth day as compared to 6-8 days in the control group. Infants with severest injury demonstrated greater reduction in MD, but no difference in time to pseudonormalization. Conclusion: TH slows the evolution of diffusion abnormalities on MRI following HIE in term infants. Copyright © 2012 by AAN Enterprises, Inc. Source

Vitaliti S.M.,Neonatology Unit
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians | Year: 2012

The authors after a brief introduction on the development of the perception of pain in the fetus and newborn, focus attention on the problem of painful procedures that are performed in the neonatal intensive care units reported in the scientific literature. Then report the design of the double-blind study that is taking place from February 2012 at the NICU ARNAS Civic - Palermo using three different concentrations of sucrose as analgesia during venipuncture and heel puncture in term neonates. Source

Zingg W.,University of Geneva | Tomaske M.,Neonatology Unit | Martin M.,Albert Ludwigs University of Freiburg
Nutrients | Year: 2012

Healthcare-associated infections (HAI) in preterm infants are a challenge to the care of these fragile patients. HAI-incidence rates range from 6 to 27 infections per 1000 patient-days. Most nosocomial infections are bloodstream infections and of these, the majority is associated with the use of central venous catheters. Many studies identified parenteral nutrition as an independent risk factor for HAI, catheter-associated bloodstream infection, and clinical sepsis. This fact and various published outbreaks due to contaminated parenteral nutrition preparations highlight the importance of appropriate standards in the preparation and handling of intravenous solutions and parenteral nutrition. Ready-to-use parenteral nutrition formulations may provide additional safety in this context. However, there is concern that such formulations may result in overfeeding and necrotizing enterocolitis. Given the risk for catheter-associated infection, handling with parenteral nutrition should be minimized and the duration shortened. Further research is required about this topic. © 2012 by the authors; licensee MDPI, Basel, Switzerland. Source

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