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Santa Maria Nuova, Italy

Gargano G.,Neonatologic Unit | Braibanti S.,Neonatologic Unit
Acta Biomedica | Year: 2014

The aim of neonatal resuscitation is to establish an effective ventilation, avoiding lung damage. PEEP and T-piece use, as well as Sustained Lung Inflation, lower O2 target and appropriately timed surfactant administration analyzed. A new "gentle" respiratory approach in delivery room can improve newborn respiratory outcome. © Mattioli 1885. Source


Gargano G.,Neonatologic Unit | Guidotti I.,Neonatologic Unit | Guidotti I.,University of Modena and Reggio Emilia | Balestri E.,Neonatologic Unit | And 12 more authors.
American Journal of Medical Genetics, Part A | Year: 2014

Fetal hydrops is a condition resulting from interstitial fluid accumulation in fetal compartments secondary to increased capillary permeability and characterized by high rates of perinatal mortality and morbidity. Clinical features include skin edema, hydrothorax, pericardial effusion, ascites with or without polyhydramnios, and placental edema. While it may occur as associated feature in multiple disorders, it has been documented to recur in Noonan syndrome, the most common disorder among RASopathies, but also in cardiofaciocutaneous and Costello syndromes. Here, we report on the occurrence of severe hydrops in a newborn heterozygous for the invariant c.4A>G missense change in SHOC2 which underlies Noonan-like syndrome with loose anagen hair, documenting that it represents a clinically relevant complication in this condition, shared by RASopathies. © 2014 Wiley Periodicals, Inc. Source

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