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Salman S.,Ministry of Health | Kumbasar S.,Ministry of Health | Yilmaz M.,Nenehatun Obstetrics and Gynecology Hospital | Kumtepe Y.,Ataturk University | And 3 more authors.
Gynecological Endocrinology

Objective.In this study, effects of chronic antihypertensive drug (clonidine, methyldopa, amlodipine, ramipril, and rilmenidine) treatment on antioxidantoxidant parameters were investigated in rat ovarian tissue. Study design.Chronic drug administration for 30 days and at the end, biochemical examinations (total glutathione (tGSH), glutathione peroxidase (GPO), glutathione reductase (GR), glutathione s-transferase (GST), superoxide dismutase (SOD), nitric oxide (NO), catalase (CAT), malondialdehyde (MDA), and myeloperoxidase (MPO) analyses) were performed. Results.The levels of glutathione (GSH) and NO, and the activities of GPO, GR, GST, SOD, and CAT were measured the lowest in ramiprile group. Also in ramiprile group, the level of MDA and the activity of MPO was the highest. Conclusion.We divided the drugs into four groups according to their biochemical side effect potentials in ovarian tissue: (I) Drugs which have no clear negative effect on ovarian tissue: clonidine, rilmenidine; (II) Drugs which have mild negative effect on ovarian tissue: methyldopa; (III) Drugs which have moderate negative effect on ovarian tissue: amlodipine; (IV) Drugs which have severe negative effect on ovarian tissue: ramipril. These data might be useful in the selection of the least toxic antihypertensive drug in pregnant and/or normal females. © 2011 Informa UK, Ltd. Source

Yilmaz O.,Erzurum District Training and Research Hospital | Olgun H.,Ataturk University | Ciftel M.,Erzurum District Training and Research Hospital | Kilic O.,Erzurum District Training and Research Hospital | And 4 more authors.
Cardiology in the Young

Introduction: Dilated cardiomyopathy is usually idiopathic and may arise secondary to infections or metabolic or genetic causes. Another rare cause is hypocalcaemia. Owing to the fact that calcium plays an essential role in excitation and contraction of myocardial muscle, myocardial contractility may decline in patients with hypocalcaemia. Materials and Methods: Patients with symptoms of congestive heart failure and rickets-related hypocalcaemia were assessed clinically and by echocardiography in a paediatric cardiology clinic. Echocardiography was performed for all patients. Rickets was diagnosed according to the clinical, laboratory, and radiologic findings. Maternal lifestyle and living conditions were investigated, and the maternal 25-OH vitamin D3 blood level was measured. Results: We evaluated eight patients who developed heart failure as a result of severe hypocalcaemia associated with rickets between August, 1999 and June, 2012. The age distribution of the patients was 3-12 months. Laboratory results were consistent with advanced-stage rickets. Severe hypocalcaemia was detected in all patients. The maternal 25-OH vitamin D3 levels were low. Echocardiography revealed increased pre-treatment left ventricle end-systolic and end-diastolic diameters for age and reduced ejection fraction and fractional shortening. After clinical improvement, the patients were discharged. Conclusions: Severe hypocalcaemia associated with rickets must always be kept in mind among the causes of dilated cardiomyopathy and impaired cardiac function in infants. If diagnosed and treated in time, dilated cardiomyopathy and severe heart failure related to rickets respond well. © Cambridge University Press 2013. Source

Ozkan A.,Regional Research and Education Hospital | Kumtepe Y.,Ataturk University | Delibas I.B.,Nenehatun Obstetrics and Gynecology Hospital
Research Journal of Medical Sciences

The objective of this study was to evaluate the 1 year success of the Mini Sling System in the treatment of Stress Urinary Incontinence (SUI). The subjects were 22 patients who had been treated with the Mini Sling system between July 2009 to January 2010 in the clinic. After diagnosis of genuine SUI by history, physical examination, cough stress pad test and urodynamics. The patients were evaluated at postoperative 1st, 3rd, 6th and 12th months, in terms of urinary incontinence, dyspareunia and lower urinary tract infection and symptoms. The mean operation time was 7 min. There were no intraoperative complications. At the 1st week of surgery, the Mini Sling System was totally removed from a patient due to confirmation of treatment failure. One patient had tissue reaction manifested by a palpable right inguinal nodularity at the postoperative 6th month and treated with partial mesh excision following antibiotherapy. The patient remained continent throughout the follow-up period. There were no other procedure-related complications detected within 1 year of follow-up. Objective cure and failure rates at 1 year follow-up were 95% (21/22) and 5% (1/22), respectively. In conclusion, the Mini Sling System is easy to use and effective minimally invasive method in the treatment of genuine stress incontinence. © Medwell Journals, 2012. Source

Yilmaz O.,District Training and Research Hospital | Kahveci H.,Nenehatun Obstetrics and Gynecology Hospital | Zeybek C.,District Training and Research Hospital | Ciftel M.,District Training and Research Hospital | Kilic O.,District Training and Research Hospital
American Journal of Perinatology

Objective Many vasodilator drugs, including inhaled iloprost, are used to treat insufficient pulmonary vasodilatation, which is the main issue in pulmonary hypertension in newborns. Study Design The safety and efficacy of inhaled iloprost for the treatment of pulmonary hypertension were evaluated retrospectively in 15 preterm infants diagnosed with respiratory distress syndrome and pulmonary hypertension. Results The infants were unresponsive to surfactant and conventional mechanical ventilation and thus were treated with inhaled iloprost. Oxygenation parameters and hypoxemia improved rapidly after treatment. There was no decline in systemic blood pressure, no need for increased doses of vasopressor, and no side effects during treatment. One patient died of sepsis during treatment. Conclusion In the treatment of severely sick premature babies with pulmonary hypertension, inhaled iloprost has high tolerability and a low incidence of systemic side effects. Based on the benefits of inhaled iloprost in preterm infants with pulmonary hypertension in this case series, further studies are required to evaluate its efficacy and safety in the preterm population. Copyright © 2014 by Thieme Medical Publishers, Inc. Source

Isaoglu U.,Nenehatun Obstetrics and Gynecology Hospital | Yilmaz M.,Ataturk University | Delibas I.B.,Nenehatun Obstetrics and Gynecology Hospital | Bilici A.E.,Education and Research Hospital | Kabalar M.E.,Education and Research Hospital
Archives of Medical Science

Introduction: Retrospective evaluation of cervical smear results of women who attended our gynecology policlinics with various symptoms and discussion of the results in the light of the literature. Material and methods: We performed a retrospective investigation on 37,438 Pap smear results of women who attended our hospital between January 2011 and December 2012 with a variety of symptoms. Results: Average patient age was 43 (18-83) years. Of the Pap smear results analyzed, in 21,503 (57.4%) findings were within normal limits, while 153 (0.41%) showed epithelial cell abnormalities and 15,358 (41%) showed inflammation. Four hundred and twenty-four (1.1%) cases were reported to have inadequate Pap smear samples for evaluation. Of the epithelial cell abnormalities, 136 (88.8%) were squamous cell abnormalities and 17 (11.1%) were glandular cell abnormalities. Atypical squamous cells of unknown significance (ASCUS) were reported for 117 (0.3%) Pap smears, while other epithelial abnormalities included atypical glandular cells of unknown significance (AGUS) in 17 (0.05%) cases, low-grade squamous intraepithelial lesion (LSIL) in 8 (0.02%) cases, atypical squamous cells with possible high grade lesion (ASC-H) in 8 (0.02%) cases and high-grade squamous intraepithelial lesion (HSIL) in 3 (0.008%) cases. Conclusions: Public awareness should be raised on the importance of Pap smear testing repeated at appropriate intervals in the prevention and early diagnosis of cervical cancer. Health education should become more widespread, and the importance of screening programs and regular check-ups should be emphasized more often on this issue in the media. Copyright © 2015 Termedia & Banach. Source

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