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Shillong, India

Mandal S.,GIMT | Saha G.,NEHU | Pal R.K.,University of Calcutta
Advances in Intelligent Systems and Computing | Year: 2016

Current progress in cellular biology and bioinformatics allow researchers to get a distinct picture of the complex biochemical processes those occur within a cell of the human body and remain as the cause for many diseases. Therefore, this technology opened up a new door to the researchers of computer science as well as to biologists to work together to investigate the causes of a disease. One of the greatest challenges of the post-genomic era is the investigation and inference of the regulatory interactions or dependencies between genes from the microarray data. Here, a new methodology has been devised for investigating the genetic interactions among genes from temporal gene expression data by combining the features of Neural Network and Cuckoo Search optimization. The developed technique has been applied on the real-world microarray dataset of Lung Adenocarcinoma for detection of genes which may be directly responsible for the cause of Lung Adenocarcinoma. © Springer India 2016.

Kardong D.,Dibrugarh University | Verma A.K.,NEHU | Upadhyaya S.,Dibrugarh University | Borah D.,Dibrugarh University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Objective: The present investigation was an attempt to evaluate the phytochemical constituents, free radical scavenging activities and anticancer properties of the leaf extracts of wild Sarchoclamys pulcherrima Goud, a wild vegetable plant used by Mishing tribe of Assam. Materials and methods: The phytochemical analysis, free radical scavenging activities and cytotoxic properties of the plant was carried out in the ethanolic extract of leaves of Sarchoclamys pulcherrima Goud using DMSO as neutral solvent. Results: The study indicated the presence of most of the major phytochemicals viz. alkaloids, saponins, flavonoids, tannins etc. in the leaf extract of the plant. The free radical scavenging activity of the sample against DPPH and ABTS was recorded as 84.87% and 76.9% respectively and found comparable to that of the ascorbic acid (88.2% and 83% respectively). In vitro cytotoxicity assay indicated a maximum cell damaging activity (60% Viability) at the exposure concentration (100 μg/ml leaf extract) and least activity (90% Viability) at the exposure concentration (20 μg/ml leaf extract). Conclusion: The present investigation will help to evaluate the neutraceutical prospect of the plant species with scientific validation of a traditionally acclaimed medicinal food plant.

Mitra R.,Banaras Hindu University | Bhan S.,NEHU | Nath G.,Banaras Hindu University | Kumar N.,Banaras Hindu University | Ali Z.,SRMS Institute of Medical science
The Scientific World Journal | Year: 2013

To aid the clinical diagnosis of typhoid fever in India, where most hospitals and primary health centres have no facilities for culture, we report on the development of a novel and rapid immunodiagnostic kit for the direct detection of Salmonella Typhi-specific IgG antibodies against S. Typhi flagellar H antigen. The disease often does not show a specific clinical picture, and can be confused with other febrile illness such as malaria, dengue fever and Staphylococcus aureus. To overcome the problem of cross reactivity specific epitope of the flagellar H antigen was immobilised on the testing kit strip eliminating chances of cross reactivity and false positive results thereby increasing the specificity of the test. Since the immunodiagnostic kit, uses the flagellar H antigen from bacteria present in our country, the antibodies present in the serum of patients of our country will have maximum binding affinity, enhancing the sensitivity of our test kit. The immunodiagnostic kit on analysis gave a positive result with clinically diagnosed typhoid positive patient serum and negative results were obtained with the sera of clinically diagnosed malaria, abscess of Staphylococcus aureus and Visceral leishmaniasis (Kala-azar) patients. Copyright © 2013 Rahul Mitra et al.

Singh A.D.,NERIST | Subadar R.,NEHU
AEU - International Journal of Electronics and Communications | Year: 2014

An expression for the probability distribution function (PDF) of the signal-to-noise ratio of a selection combining receiver in two-wave with diffuse power fading channel is derived. Using this PDF expression, the capacity for the different adaptive transmission techniques employing selection combining (SC) are obtained. The study presents the effects of the ratio of total dominant signal power to the scattered signal power on the system capacity. The change in the capacity of the system with the diversity order for a SC receiver in the fading channel is also presented. © 2013 Elsevier GmbH.

Subadar R.,NEHU | Singh A.D.,NERIST
AEU - International Journal of Electronics and Communications | Year: 2014

An expression of characteristic function of signal-to-noise ratio (SNR) for two waves with diffused power (TWDP) fading channel is derived. Using this expression, the expression for the probability density function (PDF) of the output SNR of maximal ratio combining (MRC) receiver is obtained. Expressions for the performance matrix of MRC receiver over TWDP fading channels are also deduced. PDF based approach is followed to derive expressions of outage probability and average symbol error rate for coherent and non-coherent m-ary modulation schemes. Effects of the number of branches M and the fading parameters K and Δ on the system performance are studied. The results obtained are verified by Monte Carlo simulation. © 2014 Elsevier GmbH.

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