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Varma V.,Near University | Sowmya C.,Near University | Tabasum S.G.,Near University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Piroxicam is a long acting potent NSAID with inflammatory potency and good analgesic-antipyretic action. It is a reversible inhibitor of COX lowers PG concentration in synovial fluid and inhibits platet aggregation prolonging bleeding time. In addition it decreases to IgM rehumatoid factor and leucocyte chemotaxis. Thua it can inhibit inflammation in diverse ways. Solid dispersion were by preliminary solubility analysis was carried out for the selection of carriers and solid dispersion was prepared with PEG 4000 PEG 6000 and mannitol. To increase the solubility of drug solid dispersion was prepared. These solid dispersions were analysed for the solubility and Invitro dissolution profile, solid dispersion of drug with PEG 6000 had shown enhanced solubility with improved dissolution rate. The FTIR and DSC studies revealed that there is no interaction between drug and carriers. Solid dispersion prepared with PEG 4000 shows the presence of amorphous form confirmed by the characterization study like SEM sudies. The study also shows the dissolution rate of Piroxicam can be enhanced to considerable extent by solid dispersion technique with PEG.

Chungath T.T.,Near University | Padmanabha Reddy Y.,Near University | Devanna N.,Jawaharlal Nehru Technological University Anantapur
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

A rapid and sensitive method for the determination of miglitol in tablet formulations using an internal standard has been developed and validated using C 8 column. The mobile phase consisted of sodium dihydrophosphate: acetonitrile in a ratio of 85:15 at a flow rate of 1ml/min. The detection was carried out at 232nm and the linearity was found to be in the range of 1-11 μg/ml. The retention time for drug and internal standard was found to be 3.40 and 7.30 min respectively. The method was validated for linearity, accuracy, specificity, limit of quantification, limit of detection and stability. The limit of quantification (LOQ) and limit of detection (LOD) for the estimation of miglitol was found to be 900ng/ml and 500ng/ml respectively. The method was validated as per ICH guidelines. Studies proved that about 99.52% of the drug could be recovered indicating high accuracy for the proposed method.

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