News Article | May 23, 2017
PHILADELPHIA--(BUSINESS WIRE)--Three individuals have been elected to the board of directors of Philadelphia-based National Disease Research Interchange (NDRI). Lending their experience and insight to the nation’s leading source of human organs, cells and tissues for research are Shawn Blackburn, CEO, YPrime, Malvern, PA; Sulayman Dib-Hajj, PhD, Senior Research Scientist, Yale School of Medicine and VA Connecticut Healthcare System, West Haven, CT; and Megan Kasimatis Singleton, JD, MBE, CIP, Assistant Dean and Director of the Human Research Protection Program, Johns Hopkins University School of Medicine, Baltimore, MD. Blackburn, Dib-Hajj and Singleton were elected on May 16 to three-year terms on the NDRI board. Mary J.C. Hendrix, PhD, Chair of the NDRI Board and President of Shepherd University shared that, “ Shawn Blackburn’s expertise in technology to support research, Dr. Dib-Hajj’s research accomplishments and experience utilizing human tissue for research and Megan Singleton’s knowledge and experience in law, bioethics and human subject protections will be invaluable to advancing the mission of NDRI.” Bill Leinweber, NDRI’s President and Chief Executive Officer, adds, “The caliber of our new board members speaks to the significant transformative work being advanced by our organization. We are honored to have these highly respected professionals commit their time and talents to the mission of NDRI.” Blackburn is a co-founder of YPrime, a clinical trial software company focused on creating innovative solutions for researchers running global clinical trials in all therapeutic areas. Under Blackburn’s leadership, YPrime has experienced exponential growth with offices in Pennsylvania and North Carolina and additional staff based in five countries. Dib-Hajj’s research has centered on the molecular basis of excitability disorders in humans including pain, with a focus on the role of voltage-gated sodium channels in the pathophysiology of these disorders, and as targets for new therapeutics. He has published more than 160 primary papers and reviews, and has established national and international collaborations with both academic and pharmaceutical groups. Dib-Hajj received his undergraduate educated from the American University of Beirut, Lebanon and his PhD from The Ohio State University. In her current role, Singleton is responsible for oversight and direction of the staff that support the seven Johns Hopkins Medicine Institutional Review Boards (IRBs). She earned her law degree from Temple University and Masters in bioethics from the University of Pennsylvania. She is a frequent presenter on a range of human research protection issues. The National Disease Research Interchange (NDRI) is the nation’s leading source of human tissues, cells and organs for scientific research. A not-for-profit 501 (c)(3) organization founded in 1980, NDRI is funded in part by the National Institutes of Health, public and private foundations and organizations, pharmaceutical and biotechnology corporations. NDRI is a 24/7 operation that partners with a nationwide network of over 130 tissue source sites (TSS), including organ procurement organizations (OPO), tissue banks, eye banks, and hospitals. The TSS, are distributed throughout the USA, in 45 states, with concentrations in major metropolitan areas on both the east and west coasts. Their wide geographic distribution allows NDRI to provide biospecimens from donor populations with diverse demographics and also facilitates the timely and efficient provision of fresh tissues directly to researchers across the country. By serving as the liaison between procurement sources and the research community, NDRI is uniquely positioned to support breakthrough advances and discoveries that can affect advances in the treatment and cure of human diseases.
Pothuraju R.,NDRI |
Sharma R.K.,NDRI |
Rather S.A.,NDRI |
Journal of Intercultural Ethnopharmacology | Year: 2016
Background: The aim of the present study was to investigate, anti-obesity effect of Aloevera (AV), and Gymnema sylvestre (GS) whole extract powders administration to high-fat diet (HFD) fed C57BL/6J mice for 12 weeks. Materials and Methods: At the end of experiment, different parameters such as body weight, feed intake, organ weights, fasting blood glucose, oral glucose tolerance test, plasma lipid levels, and expression analysis of adipocytokines were evaluated. Results: At the end of experimental period, oral administration of both herbs showed a significant (P < 0.05 and P < 0.001) decrease in the plasma glucose and lipid levels in HFD fed mice. In addition, increased in the epididymal fat (E. fat) weight in the HFD group was significantly (P < 0.05) reduced on GS administration alone. Finally, quantitative mRNA expression analysis of adiponectin gene was significantly up-regulated in AV supplementation. Further, no effect was observed with the both herbs on pro-inflammatory cytokines (interleukin 6 and tumor necrosis factor-α) in the E. fat tissue of HFD fed group. Conclusions: The anti-obesity and other metabolic studies depend on the type of diet, different parts of herbal extractions, and animal models used. Further studies are required in this area to strengthen the anti-obesity effects of herbs with active component, and it can be used a pro-drug instead of whole extract. © SAGEYA.
Saini K.,NDRI |
LWT - Food Science and Technology | Year: 2017
The probiotic potential of 5 food grade Lactobacillus strains, of human origin namely Lactobacillus fermentum (S23), Lb. fermentum NCDC77 (S8), Lb. fermentum (S25) and Lb. plantarum (S1), capable of selenium bioaccumulation (in previous studies), was investigated. The cultures, S8 and S23 maintained elevated cell numbers under conditions simulating passage through the human gastrointestinal tract, showing ability to survive in the presence of simulated gastric juice at pH 2. These cultures also survived in the presence of simulated intestinal juice with 1% bile salts. The cultures showed variable and strain dependent cell-surface hydrophobicity and auto-aggregation ability. The cultures were assayed for susceptibility to 20 antibiotics and found susceptible to 14 out of 20 antibiotics while showed variable resistance to remaining 6 antibiotics. S8 and S23 cultures showed superior antibacterial activity in comparison to remaining 3 cultures. These findings suggest that Lb. fermentum NCDC77 (S8) and Lb. fermentum (S23) cultures, endowed with the ability to accumulate high amount of selenium, exhibited high resistance against low pH and bile. Moreover, these cultures possessed adherence and auto-aggregation properties with minimum resistance to antibiotics and hence could be exploited for the development of selenium enriched functional food or nutraceutical as a source of dietary selenium. © 2017 Elsevier Ltd
Chand S.,NDRI |
Meena B.S.,NDRI |
Kadian K.S.,NDRI |
Veterinary Practitioner | Year: 2013
A descriptive study on knowledge of dairy farmers regarding reproductive disorders of dairy animals was purposely conducted in Alwar district of Rajasthan. Data were collected from 150 dairy farmers with the help of well structured interview schedule. In the study, knowledge was operationalised as the amount of information and understanding of the farmers at the time of interview about reproductive disorders of dairy animals. Majority of dairy farmers were found in medium category of knowledge regarding various reproductive disorders of dairy animals. Dairy farmers were having highest knowledge (78.98%) about abortion and stillbirth while having least knowledge (47.06%) about prolapse. It was found that dairy farmers, rearing large herd, were having higher knowledge as compare to those rearing small and medium sized herd about most of reproductive disorders of dairy animals. Education, family education status, herd size, milk production, mass media exposure and cosmopolite source of information were found positively and significantly associated with knowledge of dairy farmers on reproductive disorders of dairy animals while incidence of reproductive disorders was negatively and significantly related with knowledge of dairy farmers.
News Article | November 15, 2016
The more you drink, the greater your risk of prostate cancer: Study Alcohol is known to be a risk factor for breast cancer and at least seven types of cancers of the digestive system. It's also suggested that alcohol may increase the risk of cancers of the skin, pancreas and prostate. But some unresolved questions still remain in the underlying science. A new collaborative study done by researchers at the Centre for Addictions Research of BC (CARBC) at the University of Victoria and Australia's National Drug Research Institute (NDRI) at Curtin University provides new evidence of a significant relationship between alcohol consumption and the risk of prostate cancer. The article appears in BMC Cancer, a peer-reviewed online journal. Part of the problem with most previous studies comes from what scientists call "abstainer bias." This is the common practice of lumping together former drinkers -- including people who may have previously drank heavily, but quit or cut down due to failing health -- with those who have abstained from drinking alcohol for their whole lives. This practice can disguise the association between alcohol intake and health problems like prostate cancer by making drinkers "look good" in comparison with a group containing unhealthy former drinkers. The research team identified all previously published studies on alcohol and prostate cancer (340) and found 27 that attempted to measure the risk at different levels of consumption. Controlling for abstainer bias in their analysis of all 27 studies, they found a statistically significant dose-response relationship between amount of alcohol consumed and risk of prostate cancer among current drinkers. In other words, the more you drink, the greater your risk of prostate cancer. Even at low-volume drinking (up to two drinks per day), men had an eight per cent greater risk of prostate cancer compared to lifetime abstainers. But when the researchers examined only those six studies that were originally free of abstainer bias, the risk for low volume drinkers rose to 23 per cent. Given the high prevalence of prostate cancer, especially in the developed world, the public health implications of these fi¬ndings are signifi¬cant. It is the most commonly diagnosed cancer in men in Canada, Australia and Britain, and is the fifth most common cause of cancer death in men worldwide. "This new study contributes to the strengthening evidence that alcohol consumption is a risk factor for prostate cancer. Alcohol's contribution to prostate cancer will need to be factored in to future estimates of the global burden of disease," said UVic's CARBC director and co-author Dr. Tim Stockwell. This month is "Movember," a campaign that originated in Australia to raise funds and awareness of prostate and testicular cancer and men's health in general. The week of Nov.16 - 22 is National Alcohol Awareness Week in the UK and National Addictions Awareness Week in Canada. "These findings highlight the need for better methods in research on alcohol and health," says report co-author Dr. Tanya Chikritzhs. "Past and future studies that demonstrate protection from disease due to low-level drinking should be treated with caution." Study co-authors include Dr. Jinhui Zhao and Audra Roemer (MSc research assistant) from the University of Victoria. Tim Stockwell Director, Centre for Addictions Research of BC, University of Victoria 250-472-5445 firstname.lastname@example.org
Sacks S.,National Development and Research Institutes Inc. |
Therapeutic Communities | Year: 2010
This paper reviews the development of the modified therapeutic community (MTC) as an integrated approach to the treatment of co-occurring disorders. Four research studies are presented, each of which examined the effectiveness of the MTC within a particular population and a particular setting; all 902 volunteer subjects had mental disorders (most of these were serious disorders) co-occurring with substance use disorders, and all four studies were undertaken by the same investigative team. Significantly better outcomes were observed for the MTC group in every study, but the measures and domains in which differences were detected varied from study to study. A quantitative synthesis (using meta-analysis) detected significant improvements in outcomes for the MTC group in five of six outcome domains (substance use, mental health, crime, employment and housing); no significant differences were detected in HIV-risk. The review of research concludes with brief summaries of preliminary findings from two current studies. The paper then transitions to a closing discussion of staff training, aftercare services, and future directions for research related to the MTC. The substantial base of research supporting the efficacy of the MTC approach for persons with cooccurring disorders that has accumulated should encourage programme and policy officials to consider using MTC programmes for populations with co-occurring disorders. © The Author(s).
Kapila R.,NDRI |
Kapila S.,NDRI |
Kapasiya M.,NDRI |
Pandey D.,NDRI |
And 2 more authors.
Probiotics and Antimicrobial Proteins | Year: 2012
Six strains of lactobacilli belonging to three species (Lactobacillus casei, Lactobacillus acidophilus and Lactobacillus helveticus) were evaluated for probiotic attributes viz. acid tolerance, bile tolerance and cell surface hydrophobicity. All the six strains exhibited probiotic attributes with considerable degree of variation. Three Lactobacillus strains selected on the basis of probiotic attributes were used for preparing three different fermented milks. In order to evaluate the effect of feeding these probiotic fermented milks on macrophage cell function, an in-vivo trial was conducted in mice for a period of 2, 5 and 8 days. The control group of mice was fed with skim milk. The phagocytic activity of macrophages increased significantly (P < 0. 05) on feeding fermented milk prepared using L. acidophilus,L. casei and L. helveticus as compared to milk group (control) on 2nd, 5th and 8th day of feeding, respectively. Likewise, the release of β-glucuronidase and β-galactosidase from peritoneal macrophages increased significantly (P < 0. 05) on 2nd, 5th and 8th day of feeding as compared to their respective control group (milk). The results thus depict that feeding of probiotic fermented milk enhances phagocytic activity of the macrophages. © 2012 Springer Science + Business Media, LLC.
Clatts M.,University of Puerto Rico at San Juan |
Giang L.M.,Center for Research and Training on |
Goldsamt L.,NDRI |
Colon-Lopez V.,University of Puerto Rico at San Juan
Substance Use and Misuse | Year: 2010
Background: Surveillance studies have noted intravenous injection of promethazine hydrochloride (PHC) among populations that use heroin in south and southeast Asia. However, little is known about onset and initiation of PHC use and its relationship to habitual heroin use. Methods: As part of a longitudinal study of heroin initiation, a sample of 179 new heroin users, aged 15-27 years, were interviewed between October 2005 and December 2006 in Hanoi, Vietnam. Cox proportional hazard regression analysis was used to characterize age at promethazine initiation and its association with relevant covariates. Results: 76% reported lifetime use of PHC. Mean age of PHC initiation was 21.3 years, on average 6 months following onset of heroin injection. In multivariate analysis, lifetime use of diazepam [HR = 1.69 (1.17, 2.44); p-value = .01] and injecting heroin for more than 1.58 years [HR = 1.46 (1.04, 2.06); p-value = .03] were associated with PHC initiation. Conclusion: Intravenous injection of PHC is a relatively common practice among young injection heroin users in Hanoi, Vietnam who use it on a situational basis to substitute for heroin (when heroin is not available or when heroin is too costly) or to augment the effects of an inadequate heroin dosing (delaying onset of heroin withdraw). Existing drug prevention strategies in Vietnam are focused primarily on heroin and most new heroin users initiate PHC use without prior knowledge of its high risk for serious vein damage. Future research is needed on the PHC use among heroin users, including long-term medical consequences of PHC exposure. Copyright © 2010 Informa Healthcare USA, Inc.
PubMed | West Bengal University of Animal and Fishery Sciences and NDRI
Type: | Journal: ISRN molecular biology | Year: 2016
Toll-like receptor-4 (TLR-4) has an important pattern recognition receptor that recognizes endotoxins associated with gram negative bacterial infections. The present investigation was carried out to study nucleotide sequencing and SNP detection by PCR-RFLP analysis of the TLR-4 gene in Murrah buffalo. Genomic DNA was isolated from 102 lactating Murrah buffalo from NDRI herd. The amplified PCR fragments of TLR-4 comprised of exon 1, exon 2, exon 3.1, and exon 3.2 were examined to RFLP. PCR products were obtained with sizes of 165, 300, 478, and 409bp. TLR-4 gene of investigated Murrah buffaloes was highly polymorphic with AA, AB, and BB genotypes as revealed by PCR-RFLP analysis using Dra I, Hae III, and Hinf I REs. Nucleotide sequencing of the amplified fragment of TLR-4 gene of Murrah buffalo was done. Twelve SNPs were identified. Six SNPs were nonsynonymous resulting in change in amino acids. Murrah is an indigenous Buffalo breed and the presence of the nonsynonymous SNP is indicative of its unique genomic architecture. Sequence alignment and homology across species using BLAST analysis revealed 97%, 97%, 99%, 98%, and 80% sequence homology with Bos taurus, Bos indicus, Ovis aries, Capra hircus, and Homo sapiens, respectively.
News Article | November 14, 2016
PHILADELPHIA--(BUSINESS WIRE)--A local health system, a Doylestown mother, a regional organ and tissue procurement organization, and a physician who captured international attention taking on the NFL with his discoveries of the dangers of repeated blows to the heads of professional athletes will be honored by the National Disease Research Interchange (NDRI) Nov. 18 at the organization’s annual Service to Science recognition awards dinner in the Logan Hotel ballroom. The evening caps off a day-l