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Pandey D.,NDMC Medical College | Mehta S.,Babu Jag Jeevan Ram Hospital | Grover A.,Babu Jag Jeevan Ram Hospital | Goel N.,University of Delhi
Journal of Clinical and Diagnostic Research

Background: Routine placement of indwelling catheter preoperatively in Caesarean Section is being practiced without justified scientific evidence. Aim: To evaluate the effect of routine indwelling catheterization on the postoperative ambulation, morbidity and hospital stay in women undergoing Caesarean section. Settings and Design: Case-Control study carried in a tertiary teaching hospital. Materials and Methods: This study was carried over 150 women undergoing primary Caesarean section without any medical complication or pre-existing Urinary Tract Infections (UTI). The subjects were randomly allocated to 2 groups i.e. Group 1(Non-Catheterized; NC) and Group 2 (Catheterized for 24 hours postoperatively; C). Parameters noted were; duration of surgery, time of ambulation, postoperative voiding discomfort {graded as - no, mild, moderate-severe, by Visual Analog Scoring (VAS)}, incidence of UTI, postoperative urinary retention, need of postoperative antibiotics and duration of hospital stay. Statistical Analysis: Results were analysed using unpaired t-test. Results: There was no significant difference in duration of surgery and postoperative urinary retention in both groups. However, it was seen that non-catheterized patients had significantly earlier ambulation, shorter hospital stay, took less time for first voiding, lesser voiding discomfort, less incidence of UTI and lesser use of postoperative antibiotics. Conclusion: The routine use of indwelling catheter in Caesarean section is unscientific and unnecessary. There should be selective rather than routine catheterization. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved. Source

Chatterjee T.,Armed Forces Medical College | Gupta S.,NDMC Medical College | Sharma S.,Army Hospital R and R | Ganguli P.,Army Hospital R and R
Mediterranean Journal of Hematology and Infectious Diseases

Context: Acute promyelocytic leukemia (APL), an AML subtype, is characterized morphologically by abnormal promyelocytes. Molecular studies show three possible bcr isoforms of PML-RARα fusion gene. This study undertakes analysis of PML-RARα bcr isoforms and their correlation with haematological parameters and response to treatment in Indian patients. Aims: To study different PML-RARα bcr isoforms in Indian patients and to find any correlation with various haematological parameters and response to treatment Settings and Design: Patients diagnosed as APL on morphology or flowcytometry and confirmed by RQ PCR were included in the study. Treated APL patients or patients with relapse and on follow-up were excluded from the study. Methods and Material: Twenty patients over thirty one months period were included. The clinical, haematological & morphological features were analysed, the latter using routine & special cytochemical stains on blood and bone marrow. Flow cytometric evaluation using 4-color Beckman Coulter FC 500 and molecular studies using RT PCR Fusion Quant® kits for bcr-1, bcr-2 and bcr-3 of PML- RARα bcr isoforms on the instrument Rotor Gene™ 3000 were performed. Statistical analysis used: Student t test was applied to correlate different bcr isoforms with various haematological parameters and response to treatment. Results: In our study, M:F ratio was 1.5:1 with median age 42 years, Hb - 8.0 g/dl, TLC-7900/μl, and platelet - 35000/ μl and varied clinical presentation. Four patients were microgranular variants, and the rest were hypergranular. MPO and CAE positivity were100% and for NSE it was 33.33%. Molecular analysis revealed PML-RARα isoforms of bcr1 in 42.85%, bcr2 in 14.28% and bcr3 in 38.09% patients. No correlation was found between PML-RARα bcr isoforms, different haematological parameters and response to treatment. Conclusions: Higher incidence of PML- RARα bcr-1 isoform was found in Indian APL patients with no significant correlation between different haematological parameters and response to treatment. Source

Basu S.K.,Post Graduate Institute of Medical Education and Research | Bain J.,Post Graduate Institute of Medical Education and Research | Maity K.,Post Graduate Institute of Medical Education and Research | Chattopadhyay D.,Post Graduate Institute of Medical Education and Research | And 6 more authors.
Journal of Natural Science, Biology and Medicine

Rhinosporidiosis is a chronic localized granulomatous disease caused by Rhinosporidium seeberi, an aquatic protistan parasite belonging to a clade, Mesomycetozoea. Infestation of Rhinosporidiosis to the eye and adnexa is termed oculosporidiosis, in such cases, conjunctival mucosa is mostly involved; however in our case, it involved only the lacrimal sac and deeper periorbital tissue and presented as a case of orbital swelling. Surgical excision of the lesion was done, postoperatively dapsone therapy was given for 6 months, and the patient responded very well with no recurrence till date. © 2016 Journal of Natural Science, Biology and Medicine | Published by Wolters Kluwer - Medknow. Source

Gupta A.,Guru Gobind Singh Indraprastha University | Birhman K.,Central Drugs Standard Control Organisation | Raheja I.,Guru Gobind Singh Indraprastha University | Sharma S.K.,Guru Gobind Singh Indraprastha University | Kar H.K.,NDMC Medical College
Asian Pacific Journal of Tropical Disease

In the last decade, considerable efforts have been made to develop health promising nutritional supplements. Quercetin is a plant-derived bioflavonoid which is recently gaining scientific interest for its antioxidant free radical scavenging effects and anti-inflammatory properties. This wonder flavanol exhibits therapeutic potential in various ailments like cancer, coronary artery, asthma and alzheimer (neurodegeneration) diseases. Additional clinical uses include treatment of inflammatory conditions like gout, pancreatitis and prostatitis. It has been extensively studied for its gastroprotective effects, anti-obesity action, immune booster, reducing risk of cataract and reduction of diabetic complications. The present review briefly discusses about biological activity, mechanism of action and therapeutic potential of quercetin in prevention and mitigation of diseases. © 2016 Asian Pacific Tropical Medicine Press. Source

Gupta P.,NDMC Medical College | Kumar A.,Sanjay Gandhi Memorial Hospital
Fetal and Pediatric Pathology

Amelia and Meromelia may either present as an isolated defect or associated with other malformations; and the diagnosis is mainly clinical. The antenatal period of the case presented here was medically unsupervised but uneventful. The baby had bilateral upper limb Meromelia and bilateral lower limb Amelia along with a small ostium secundum atrial septal defect. Except for the young age of mother, there was no other obvious risk factor in this case. The baby had a normal and healthy neonatal outcome whereas most such cases are either stillborn or end in early neonatal death. © 2014 Informa Healthcare USA, Inc. Source

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