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Lu C.-H.,Tri Service General Hospital | Hung Y.-J.,Tri Service General Hospital | Hsieh P.-S.,NDMC | Hsieh P.-S.,Institute of Preventive Medicine
European Journal of Pharmacology | Year: 2016

We investigated the effects of metformin and celecoxib on obesity-induced adipose tissue inflammation, insulin resistance (IR), fatty liver, and high blood pressure in high-fat (HF) fed rats. Male Sprague-Dawley rats were fed with either regular or HF diet for 8 weeks. Rats fed with regular diet were treated with vehicle for further 4 weeks. HF fed rats were divided into 6 groups, namely, vehicle, celecoxib (30 mg/kg/day), metformin (300 mg/kg/day), metformin (150 mg/kg/day), metformin (300 mg/kg/day) with celecoxib (30 mg/kg/day), and metformin (150 mg/kg/day) with celecoxib (15 mg/kg/day) for additional 4 weeks. Increased body weight in HF fed rats was significantly reduced by metformin alone and metformin combined with celecoxib. The increases in the HOMA-IR value and the area under the curve of glucose following an oral glucose tolerance test, systolic blood pressure, and adipocyte size were significantly diminished in treated rats, especially rats undergoing combined treatment. Treatments with either celecoxib or in combination with metformin resulted in a reduction in AT macrophage infiltration and decreases in levels of adipose tissue TNF-α, MCP-1, and leptin levels in high-fat (HF) fed rats. Furthermore, the elevated hepatic triglycerides content was significantly decreased in the combined treatment group compared to that of groups of celecoxib or metformin alone. Celecoxib exerts a synergistic beneficial effect with metformin on and obesity-associated metabolic and cardiovascular disorders in high-fat fed rats. © 2016 Elsevier B.V.

Tian Y.-F.,Chi Mei Medical Center | Tian Y.-F.,Chia Nan University of Pharmacy and Science | Hsia T.-L.,Cardinal Tien Hospital | Hsieh C.-H.,Tri Service General Hospital | And 4 more authors.
Life Sciences | Year: 2011

Aim: This study was undertaken to examine the effect of cyclooxygenase (COX) 2 inhibition on the development of muscular insulin resistance in high-fat-induced obese rats. Main methods: The rats were on a regular chow diet (C) or high-fat enriched diet (HFD) energy-restrictedly (HFr), or ad libitum (HFa) for 12 weeks. The rats fed HFD ad libitum were further divided into 3 groups: oral gavage with vehicle (HFa), selective COX-2 inhibitors-celecoxib (HFa + C) or nimesulid (HFa + N), 30 mg/kg/day, respectively. Key findings: Increased fasting plasma insulin, triglyceride and 8-isoprostane levels in HFa were significantly suppressed in those of HFa + C and HFa + N. The whole body insulin resistance of HFa indicated by the increased fasting plasma insulin levels and the elevated area under curve of insulin obtained from the oral glucose tolerance test were significantly reversed in those combined with celecoxib and nimesulid administration compared with those in HFr. The gene expression of COX-2 was significantly increased in epididymal fat but not in soleus muscle in HFa and the enhanced adipose COX-2 expression in high-fat fed rats was suppressed by those with drug treatment. Both selective COX-2 inhibitors reversed the diminished insulin-stimulated glucose uptake and GLUT4 translocation in skeletal muscles of HFa. Obesity-induced oxidative stress indicated by the elevated plasma 8-isoprostane,the decreased ratio of GSH/GSSG and increased TBARS in soleus muscle were significantly reversed by COX-2 inhibition. Significance: The results suggest that COX-2 inhibition might suppress the muscular insulin resistance indirectly through decreasing the COX-2-mediated systemic oxidative stress in this diet-induced obese model. © 2011 Elsevier B.V.

Varshney L.,Banaras Hindu University | Varshney V.,NDMC | Newwel A.,Banaras Hindu University | Saket R.K.,Banaras Hindu University
Lecture Notes in Electrical Engineering | Year: 2013

This paper presents design of a squirrel cage rotor for safety and reliability improvement a three phase induction machine. Induction motor with designed rotor is capable for use in overloading conditions. Presented rotor design reduces problems related to temperature rise, tooth pulsation loss, cooling, vibration, crawling, cogging and voltage ripples in three phase induction machine. This design reduces pulsation loss, unbalanced magnetic pull and noise in the machine with increase in the air gap length. Overload capacity and reliability improves with increase the air gap length of the machine. © 2013 Springer Science+Business Media New York.

Chida A.,National Defense Medical College NDMC | Yanagawa Y.,NDMC | Matsumoto H.,National Defense Medical College NDMC | Nonoyama S.,National Defense Medical College NDMC
Indian Journal of Pediatrics | Year: 2011

Craniometaphyseal dysplasia is a rare congenital disorder that can cause craniofacial skeleton and tubular bone anomalies. A 7-month-old girl, with congenital facial palsy, mouth breathing, and nasal obstruction, was brought to the hospital because she suffered sudden cardiopulmonary arrest. Computed tomography showed bony narrowing of the choanae. The diagnosis was cardiopulmonary arrest triggered by asphyxia caused by severe choanal stenosis. She showed hypoxic encephalopathy and underwent a tracheotomy and an operation to enlarge choanae. When a neonate or young infant shows signs of nasal obstruction, physicians should aggressively search for and consider the possibility of choanal atresia or severe stenosis. © 2011 Dr. K C Chaudhuri Foundation.

Tian Y.-F.,Chi Mei Medical Center | Tian Y.-F.,Chia Nan University of Pharmacy and Science | Hsieh C.-H.,Tri Service General Hospital | Hsieh Y.-J.,NDMC | And 4 more authors.
European Journal of Clinical Investigation | Year: 2012

Background This study was undertaken to evaluate the preventive effect of α-lipoic acid (LA) on chronic mild portal endotoxaemia-mediated subacute hepatic inflammation and pancreatic β cell dysfunction in rats. Materials and methods Male Sprague-Dawley rats were randomly assigned into four groups: those with intraportal vehicle (saline) or low-dose lipopolysaccharide (LPS) (0·42ng/kg/min) infusion, combined with oral administration of vehicle or LA, a potent antioxidant (60mg/kg/day) for 4weeks. The hyperglycaemic clamp and euglycaemic clamp techniques were used to access the glucose-stimulated insulin secretion and systemic insulin sensitivity in vivo. Results Body weight, fasting plasma glucose and insulin were not different among groups. In rats with chronic intraportal LPS infusion, plasma C-reactive protein, amylase, superoxide levels, the contents of thiobarbituric acid-reactive substance, tumour necrosis factor α and interleukin 6 in liver and pancreas and also the gene expression of Toll-like receptor 4 in liver were significantly increased as compared with those with LA cotreatment. The histopathological examination showed that inflammatory changes were clearly visible in liver and pancreatic islets of LPS-infused rats and rarely observed in those cotreated with LA. In addition, low-dose intraportal LPS infusion also significantly impaired glucose-stimulated insulin secretion but not affect the systemic insulin sensitivity and metabolic clearance rate of insulin. LA administration markedly reversed LPS-induced β cell dysfunction. Conclusions α-Lipoic acid cotreatment could significantly prevent mild portal endotoxaemia-induced chronic hepatic inflammation and impaired pancreatic insulin secretion in absence of changing systemic insulin resistance. © 2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation.

News Article | October 26, 2016
Site: cleantechnica.com

The net metering policy in India’s capital city of Delhi has finally found favor among the power consumers, data released by at least three utilities operating the city suggest. Delhi has had a history of experimenting, rather unsuccessfully, with net metering policy and regulations. Now, BSES — a utility servicing a very large part of the Delhi — has reported that it has already commissioned 206 net metering connections in its service area. BSES is also working on 50 more connections with cumulative capacity of 1.5 MW. BSES has claimed that it is the first utility in the country to have scored more than 200 net metering connections. Industrial and commercial consumers, as well as schools, have given positive response to the scheme. However, participating from the domestic sector, household consumers have also been very encouraging. More than a third of the net metering connections have been availed by household consumers — a possible sign that the falling prices of solar modules, financial advantages of net metering, and cheaper loans made available by banks have resonated with consumers. Another utility operating in the city — New Delhi Municipal Corporation (NDMC) — has announced that it has received net metering applications for solar rooftop systems at 102 buildings in its service area. The utility already has 45 net metering connections operational. Along with the new connections, the total rooftop solar power capacity under the net metering scheme will increase to 5.6 MW. The Delhi government has announced plans to install 1 GW worth of rooftop solar capacity in the capital over the next 4 to 5 years, with a medium-term target to have a total of 2 GW of installed solar power capacity by 2025. The Delhi government is looking to set up solar power systems atop bus stops, metro stations, and railway stations. Buy a cool T-shirt or mug in the CleanTechnica store!   Keep up to date with all the hottest cleantech news by subscribing to our (free) cleantech daily newsletter or weekly newsletter, or keep an eye on sector-specific news by getting our (also free) solar energy newsletter, electric vehicle newsletter, or wind energy newsletter.

News Article | December 10, 2015
Site: cleantechnica.com

In the last meeting of Wednesday, December 9, the Comité de Paris (Paris Committee) of the COP21 climate conference reconvened to register the reactions of conference parties to the draft agreement Laurent Fabius presented at 9 am today. Fabius opened by proposing that after Comité de Paris session closes, parties reconvene in the indaba format on differentiation, finance, and ambition issues. (“Indaba” originated as an important conference held by the izinDuna [principal men] of the Zulu or Xhosa peoples of South Africa.) He indicated that other unresolved text could be addressed in parallel in an indaba facilitated by Manuel Pulgar-Vidal of Peru, President of last year’s COP20 in Lima. Malaysia got the best laugh (see below). The International Institute for Sustainable Development’s Earth Negotiations Bulletin team (IISDRS ‏@enbclimate) at the UNFCCC climate change negotiations captured the delegate group impressions below in tweet form. Following is a twitter transcription. South Africa, speaking for the G-77/China, the largest voting bloc: Concern about steady de-linking of the text from the Convention. No long-term vision on provision of support. Text is good basis for continuing our interactions. Switzerland, for the Environmental Integrity Group: Acceptable starting point for further work. Concern that text as whole is unbalanced, especially on financing. Range of options not balanced. Text as it stands reflects compromise proposal & the hard position of other parties. Maldives, for the Alliance of Small Island States: Prepared to move forward w/ text as basis. Must see below 1.5 degrees. Llnkage to adaptation & mitigation, & separate article on loss & damage should be maintained. Barbados, for the Caribbean Community: On long-term temp. goal, options on 2 degrees are not acceptable, willing to work on both on 1.5. Not willing to sign onto any agreement which is certain death for our people. Turkey: Prepared to work with all parties on common landing area. Australia, for the Umbrella Group: Serious concerns, cannot see balance in the text, and leaves critical issues unresolved. We have provided reassurances that developed countries will continue to lead. We want a genuine step-change in addressing global climate change. Ukraine: Satisfied w/ progress so far, looking forward to further cooperation. China, for BASIC (India, China, Brazil, and South Africa): Need to reach consensus. Current text is open & balanced text & basis to address further issues. Angola, for Least Developed Countries: Highlighted need to ensure access to finance & need further work on compliance to ensure implementation. Guatemala, for the Independent Association of Latin America and the Caribbean: Transparency system is very important & human rights should be included in agreement. European Union: Time has come to resolve the key political issues to reach ambitious outcome. some options cross our red-lines & we are concerned that language important to ambition is much weakened. Russian Federation: Is 48 hours enough? We must work concretely on text to find compromises. Saudi Arabia, for the Arab Group: Called for reinstatement of co-benefits of adaptation for mitigation. Options w/ specific numbers would possibly not make the agreement durable. who will judge “those in a position to do so,” this concept cannot be accepted. Malaysia, for the Like-Minded Developing Countries: Everyone seems unhappy so perhaps the text is balanced. Missing items, incl. absence of text on unilateral measures, & introduction of other items. Concerned by reference to NDMC, declaration that 2bis cannot be accepted & differentiation be eliminated from 3.3. COP21 President Fabius said that the revised text presented tomorrow should be the penultimate (second to last) text. He called for parties to avoid restating their positions, but rather move toward compromise. Fabius closed the meeting at 11:28 pm. Indabas commenced at midnight. These overnight consultations will cover treaty sections on loss and damage, mechanisms, forest, and preamble. Another Indaba will be held on differentiation, support, and ambition.    Get CleanTechnica’s 1st (completely free) electric car report → “Electric Cars: What Early Adopters & First Followers Want.”   Come attend CleanTechnica’s 1st “Cleantech Revolution Tour” event → in Berlin, Germany, April 9–10.   Keep up to date with all the hottest cleantech news by subscribing to our (free) cleantech newsletter, or keep an eye on sector-specific news by getting our (also free) solar energy newsletter, electric vehicle newsletter, or wind energy newsletter.  

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