NCPC Hebei huamin pharmaceutical Co.

Shijiazhuang, China

NCPC Hebei huamin pharmaceutical Co.

Shijiazhuang, China
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Jia Q.,NCPC Hebei Hua min Pharmaceutical Co. | Sun L.,CSPC Innovation Pharmaceutical Co. | Lu X.,NCPC Hebei Hua min Pharmaceutical Co. | Zhang L.-B.,NCPC Hebei Hua min Pharmaceutical Co. | And 2 more authors.
Chinese Journal of Antibiotics | Year: 2014

Objective To study thermal stability of cefixime and improve the product quality. Methods Comparing the stability data of the cefixime with different crystal particle size and type, the key factors impacting on its stability were confirmed. Results The crystal particle size and type of cefixime can impact on its thermostability. The great crystal particle size and uniform type is benefit for the thermostability. Conclusion The quality of cefixime is improved by studying its thermostability.

Sun H.,Hebei University of Science and Technology | Liu B.,Hebei University of Science and Technology | Liu P.,Hebei University of Science and Technology | Zhang J.,NCPC Hebei Huamin Pharmaceutical Co. | Wang Y.,Tianjin University
Journal of Chemical and Engineering Data | Year: 2016

Solubility of fenofibrate in ethanol-water and acetone-water mixtures was investigated using dynamic laser monitoring at atmospheric pressure and temperatures between 278.15 and 308.15 K. Solubility increased as temperature and the fraction of organics increased. The solubility data was correlated with the modified Apelblat, NRTL, combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K), and Jouyban-Acree (J-A) models. Solvent composition and temperature correlations were conducted, and the apparent dissolution enthalpy, entropy, and Gibbs free energy change of the fenofibrate were calculated using the modified Apelblat model and the van't Hoff equation. The results shoLw that the dissolution of fenofibrate is endothermic and nonspontaneous, and that the main contributor in the binary solvents studied is enthalpy. © 2016 American Chemical Society.

Wang X.,CAS Institute of Process Engineering | Wang X.,Beijing University of Chemical Technology | Liu Q.-F.,CAS Institute of Process Engineering | Wang Y.-Q.,CAS Institute of Process Engineering | And 3 more authors.
Guocheng Gongcheng Xuebao/The Chinese Journal of Process Engineering | Year: 2014

Preparation of aluminum hydroxide from industrial residue of aluminum alloy surface treatment process was studied. The leaching process of Al from the industrial residue by NaOH solution and precipitation of Al(OH)3 from Al leaching solution by H2SO4 were explored. The effects of the concentration and dosage of alkali or acid, reaction temperature and time were examined. Process optimization was obtained by orthogonal experiments. The chemical composition, morphology and quality of Al(OH)3 product were examined as well. The results showed that the Al content in the dry residue was 28.7%, and Al existed as the form of Al(OH)3 crystal in the industrial residue. The optimum conditions of leaching process were the molar ratio of NaOH addition to Al(OH)3 in the industrial residue 2.88:1, reaction temperature 75℃, and reaction time 55 min. At these conditions, the maximum yield of aluminum in leaching process reached up to 97.5%. At the optimal conditions of precipitation process of Al(OH)3, such as the molar ratio of H2SO4 addition to AlO2 - in leaching solution (0.95~1.10):1 and pH value 5.5, the precipitation yield of Al(OH)3 reached up to 89.2%, and the total recovery rate of aluminum was obtained by 87.1%. The Al(OH)3 product was amorphous with the diameter of particles of about 17 μm. The purity of Al(OH)3 in the product was up to 95.5%. ©, 2014, Science Press. All right reserved.

Liu Y.,Beijing University of Technology | Ma J.,NCPC Hebei huamin pharmaceutical Co.
Frontiers in Heat and Mass Transfer | Year: 2015

This paper presents an exact solution for the magnetohydrodynamic (MHD) flow of an incompressible generalized Oldroyd-B fluid due to an infinite accelerating plate. The fractional calculus approach is introduced to establish the constitutive relationship of the Oldroyd-B fluid. The solutions in terms of Fox H-function are obtained by using the Laplace transform. When N = 0 the solutions corresponds to the generalized Oldroyd-B fluids, while θ ®→ and λ →0 describes the Maxwell fluid and the generalized second fluid, as limiting cases of our general results, respectively. © 2015, Global Digital Central. All rights reserved.

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