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Miulescu R.D.,Carol Davila University of Medicine and Pharmacy | Miulescu R.D.,Nc Paulescu National Institute Of Diabetes | Margina D.,Carol Davila University of Medicine and Pharmacy | Culman M.,Carol Davila University of Medicine and Pharmacy | And 4 more authors.
Romanian Journal of Diabetes, Nutrition and Metabolic Diseases | Year: 2013

Background and Aims. Previous studies have shown that impaired glucose tolerance is present in patients with pheochromocytoma with a prevalence of 25-75%. The aim of this study was to examine glucose tolerance in 12 patients with pheochromocytoma, before and after medical and surgical treatment. Material and Methods. We evaluated 12 patients aged between 44 and 60 years with confirmed pheochromocytoma. Plasma insulin, fasting blood glucose and 2h glucose levels during the oral glucose tolerance test (OGTT) were measured before and three months after surgical removal of the tumor. Results. Surgical removal of the tumor generated significant changes in plasma and urinary metanephrines (plasma normetanephrine 191.15±13.22 pg/ml after treatment vs. 792.54±86.74 pg/ml at baseline, p<0.0001, plasma metanephrine 86.69±4.48 pg/ml vs. 363.62.±21.69 pg/ml, p<0.0001, urinary normetanephrine 718.54±37.59 μg/day after treatment vs. 1855.77±116.54 μg/day at baseline and urinary metanephrine of 258.31±34.00 μg/day vs. 745.38±65.14 μg/day, p<0.0001) but not in insulin, fasting and 2h glucose levels during OGTT. Conclusion. In our study, the prevalence of impaired glucose tolerance in patients with confirmed pheochromocytoma was 8.33% (1 patient with a previous family history of diabetes). After surgical removal of the tumor, normalization of mean glucose levels of OGTT was not achieved. © 2013 ILEX PUBLISHING HOUSE, Bucharest, Roumania. Source


Ionescu-Tirgoviste C.,Nc Paulescu National Institute Of Diabetes | Gagniuc P.A.,Nc Paulescu National Institute Of Diabetes | Guja C.,Nc Paulescu National Institute Of Diabetes
Acta Endocrinologica | Year: 2014

The pathogenesis of type 1 diabetes became a history longer and longer. There are 40 years since the immunogenetic theory of type 1 diabetes has been launched. Near this anniversary a challenge of this theory was recently published. We give here our interpretation of primary cause of type 1 diabetes which must be connected with the pathogenesis of other phenotypes of diabetes which has a main similar mechanism: the β-cell dysfunction. Source


Mogos T.,Nc Paulescu National Institute Of Diabetes | Dondoi C.,Nc Paulescu National Institute Of Diabetes | Chelan C.,Nc Paulescu National Institute Of Diabetes | Iacobini A.E.,Nc Paulescu National Institute Of Diabetes
Romanian Journal of Diabetes, Nutrition and Metabolic Diseases | Year: 2015

Both the medical practice and the scientific research proved that a number of nutritional products or nutritive elements could have a preventive role (especially in subjects in whom these reach a lower level than the physiological ones) in the prevention of cancer. The list of these products is quite large, but in this article we shall present only part of them. We emphasize that the aliments described are easy to find and are not expensive. Source

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