Hu L.,Hebei University |
Jia Y.,Hebei University |
Niu F.,NBP Pharmaceutical Company Ltd |
Jia Z.,Tangshan College |
And 2 more authors.
Journal of Agricultural and Food Chemistry | Year: 2012
A new microemulsions system of curcumin (CUR-MEs) was successfully developed to improve the solubility and bioavailability of curcumin. Several formulations of the microemulsions system were prepared and evaluated using different ratios of oils, surfactants, and co-surfactants (S&CoS). The optimal formulation, which consists of Capryol 90 (oil), Cremophor RH40 (surfactant), and Transcutol P aqueous solution (co-surfactant), could enhance the solubility of curcumin up to 32.5 mg/mL. The pharmacokinetic study of microemulsions was performed in rats compared to the corresponding suspension. The stability of microemulsions after dilution was excellence. Microemulsions have significantly increased the Cmax and area under the curve (AUC) in comparison to that in suspension (p < 0.05). The relative bioavailability of curcumin in microemulsions was 22.6-fold higher than that in suspension. The results indicated that the CUR-MEs could be used as an effective formulation for enhancing the oral bioavailability of curcumin. © 2012 American Chemical Society.
Hu L.,Hebei University |
Hu Q.,Hebei University |
Hu Q.,NBP Pharmaceutical Company Ltd |
Yang J.,Hebei University |
Yang J.,NBP Pharmaceutical Company Ltd
Iranian Journal of Basic Medical Sciences | Year: 2014
Objective(s): The objective of this study was to find a stable microemulsion vehicle for transdermal delivery of ibuprofen to improve the skin permeability.Materials and Methods: Microemulsion was prepared using different sorts of oils, surfactants and co-surfactants. Pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. The effects of oleic acid and surfactant mixture on skin permeation of ibuprofen were evaluated with excised skins.Results: The optimum formulation F3 consisting of 6% oleic acid, 30% Cremophor RH40/Transcutol P (2:1, w/w) and 59% water phase, showed a high permeation rate of 42.98 μg/cm2/hr. The mean droplet size of microemulsion was about 43 nm and no skin irritation signs were observed on the skin of rabbits.Conclusion: These results indicated that this novel microemulsion is a useful formulation for the transdermal delivery of ibuprofen. © 2014, Mashhad University of Medical Sciences. All rights reserved.