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Nazareth, Israel

Shah S.A.,Forman Christian College | Majeed A.,Nazareth Hospital | Rashid K.,Pakistan Council of Scientific and Industrial Research | Awan S.-U.,Quaid-i-Azam University
Materials Chemistry and Physics

Superparamagnetic iron oxide-based nanoparticles (SPIONS) have attracted an enormous attention for their potential use in biomedical applications due to their good biocompatibility and low toxicity. Current study is about doxorubicin-loaded multifunctional MnFe2O4 nanoparticles surface-modified with polyethylene glycol (PEG) & folic acid (FA) for multimodal cancer therapy. Infrared spectroscopy and thermogravimetric data confirmed this surface modification. Nanoparticles were of moderate colloidal dispersion due to PEG coating. Composite nanoparticles having mean diameter of about 22 nm were of core-shell structure having about 31% (wt) organic shell over the (remaining) magnetic core. MnFe2O4 core of about 16 nm was superparamagnetic due to the pseudo-single domain structure. Drug loading & releasing were efficient in the initial 8 h and gradual in later hours. Magnetic heating was studied by exposing the magnetic fluid to high frequency magnetic field. Temperature of the fluid rose to 45 °C from 25 °C in about 22 min, which is an effective and appropriate temperature for the localized hyperthermia treatment of cancer. © 2013 Elsevier B.V. All rights reserved. Source

Background: Simultaneous augmentation mastopexy for moderately to severely ptotic breasts presents the challenge of determining how much excess skin should be removed after implant placement to create symmetry and provide for maximal skin tightening without compromising tissue vascularization. Methods: Simultaneous augmentation mastopexy involves invagination and tailor tacking of the excess skin after implant placement and then making a pattern around the tailor-tacked tissues for previsualization of the total area to be resected. This contrasts with first making a pattern for the mastopexy, resecting the skin, and then tailor tacking the tissues together. Over a 7-year period, 55 women had simultaneous augmentation mastopexy with this approach. Saline implants were placed in the subpectoral dual-plane position before the mastopexy was started. All surgeries were performed with the patient under general anesthesia, and the patients were discharged the same day. In a retrospective chart review, breast implant size, degree of preoperative asymmetry, length of procedure, and complications were recorded. The patient follow-up period ranged from 3 months to 7 years (median, 9 months). Results: Symmetric, aesthetic results were achieved for all the patients. The range of saline implants used was 375-775 ml (average, 500 ml). Of the 55 women, 15 had two different size implants measuring at least 50 ml or larger, with the greatest size disparity in a patient being 225 ml (left breast, 700 ml; right breast, 475 ml). Six of the patients (10.9%) had small areas that healed by secondary intention, occurring mostly at the inferior junction of the inverted T. Only two patients (3.6%) had recurrence of breast ptosis, and only one patient (1.8%) had a mildly hypertrophic scar. There were no incidences of hematoma, infection, rippling, malposition of the nipple-areolar complex (NAC), NAC loss, capsular contraction, implant malposition, or dissatisfaction with implant size. The bilateral augmentation/mastopexy surgery time ranged from 2 h and 29 min to 4 h and 30 min (average, 3 h and 8 min). Conclusions: The described technique maximizes the amount of tissue to be resected in simultaneous augmentation mastopexy for moderately to severely ptotic breasts. Symmetry is more easily achieved with this approach regardless of the implant size used or the amount of skin to be resected. This technique minimizes the chance of tissue necrosis from devascularized skin edges. It also may shorten the inverted T scar and reduce the operative time. © Springer Science+Business Media, LLC and International Society of Aesthetic Plastic Surgery 2011. Source

Tate A.,Arcadia University | Turner G.N.,Drayer Physical Therapy | Knab S.E.,Nazareth Hospital | Jorgensen C.,Arcadia University | And 2 more authors.
Journal of Athletic Training

Context: The prevalence of shoulder pain among competitive swimmers is high, but no guidelines exist to reduce shoulder injuries. Elucidating differences between swimmers with and without shoulder pain can serve as a basis for the development of a program to prevent shoulder injury that might lead to pain and dysfunction. Objective: To determine whether physical characteristics, exposure, or training variables differ between swimmers with and without shoulder pain or disability. Design: Cross-sectional study. Setting: Multisite swimming centers. Patients or Other Participants: A total of 236 competitive female swimmers aged 8 to 77 years. Data Collection and Analysis: Participants completed the Penn Shoulder Score and underwent testing of core endurance, range of motion, muscle force production, and pectoralis minor muscle length and the Scapular Dyskinesis Test. Swimmers were grouped by age for analysis: ages 8 to 11 years (n = 42), 12 to 14 years (n = 43), 15 to 19 years (high school, n = 84), and 23 to 77 years (masters, n = 67). Comparisons were made between groups with and without pain and disability using independent t tests for continuous data and χ 2 analyses and Fisher exact tests for categorical data. © by the National Athletic Trainers' Association, Inc. Source

Kurkalang S.,North - Eastern Hill University | Banerjee A.,North - Eastern Hill University | Ghoshal N.,North - Eastern Hill University | Dkhar H.,Nazareth Hospital | Chatterjee A.,North - Eastern Hill University
BMC Cancer

Background: There are strong indications for a causal association between areca-nut consumption and cancers. In Meghalaya, India, the variety of areca-nut is used as raw and unprocessed form whose chemical composition and pharmacological actions have been reported. Yet we know little on the initial pathway involved in areca-nut associated carcinogenesis since it is difficult to assess its effects on genetic alterations without interference of other compounding factors. Therefore, present study was undertaken in mice to verify the ability of raw areca-nut (RAN) to induce cancer and to monitor the expression of certain genes involved in carcinogenesis. This study was not intended to isolate any active ingredients from the RAN and to look its action.Methods: Three groups of mice (n = 25 in each) were taken and used at different time-points for different experimental analysis. The other three groups of mice (n = 15 in each) were considered for tumor induction studies. In each set, two groups were administered RAN-extract ad libitum in drinking water with or without lime. The expression of certain genes was assessed by conventional RT-PCR and immunoblotting. The mice were given the whole RAN-extract with and without lime in order to mimic the human consumption style of RAN.Results: Histological preparation of stomach tissue revealed that RAN induced stomach cancer. A gradual increase in the frequency of precocious anaphase and aneuploid cells was observed in the bone marrow cells with a greater increment following RAN + lime administeration. Levels of p53, Bax, Securin and p65 in esophageal and stomach cells were elevated during early days of RAN exposure while those of different mitotic checkpoint proteins were downregulated. Apoptotic cell death was detected in non-cancerous stomach cells but not in tumor cells which showed overexpression of Bax and absence of PARP.Conclusion: Present study suggested (a) RAN induces stomach cancer, however, presence of lime promoted higher cell transformation and thereby developed cancer earlier, (b) perturbations in components of the chromosome segregation machinery could be involved in the initial process of carcinogenicity and (c) the importance of precocious anaphase as a screening marker for identification of mitotic checkpoint defects during early days. © 2013 Kurkalang et al.; licensee BioMed Central Ltd. Source

Memiah P.,University of Maryland Baltimore County | Mbuthia W.,Nazareth Hospital | Kiiru G.,Nazareth Hospital | Agbor S.,University of Maryland Baltimore County | And 3 more authors.
AIDS Research and Treatment

Objective. To assess the prevalence and identified associated risk factors for precancerous cervical cancer lesions among HIV-infected women in resource-limited settings in Kenya. Methods. HIV-infected women attending the ART clinic at the Nazareth Hospital ART clinic between June 2009 and September 2010. Multivariate logistic regression model with odds ratios and 95% confidence intervals (CI) were estimated after controlling for important covariates. Result. A total of 715 women were screened for cervical cancer. The median age of the participants was 40 years (range 18-69 years). The prevalence of precancerous lesions (CINI, CINII, CIN III, ICC) was 191 (26.7%). After controlling for other variables in logistic regression analysis, cervical precancerous lesions were associated with not being on ART therapy; whereby non-ART were 2.21 times more likely to have precancerous lesions than ART patients [ (aOR)=2.21, 95% CI (1.28-3.83)]. Conclusion. The prevalence of precancerous cervical lesions was lower than other similar settings. It is recommended that cancer screening of HIV-infected women should be an established practice. Availability and accessibility of these services can be done through their integration into HIV. Prompt initiation of HAART through an early enrollment into care has an impact on reducing the prevalence and progression of cervical precancerous lesions. © 2012 Peter Memiah et al. Source

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