Smitha G.,Navabharat Institute of Pharmaceutical and Medical science |
Tapaswini G.,Navabharat Institute of Pharmaceutical and Medical science |
Sravanthi Reddy K.,Navabharat Institute of Pharmaceutical and Medical science |
Venkat ramana M.,Navabharat Institute of Pharmaceutical and Medical science |
And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014
In the present study, an attempt has been made to find the best formulation by comparative evaluation of fast dissolving tablets of Irbesartan prepared by two different methods namely wet granulation and sublimation technique. Fast dissolving tablets of Irbesartan are prepared with a simple idea of improving the patient compliance. In the wet granulation method, tablets were prepared using superdisintegrants namely sodium starch glycollate (1,2,3,4%w/w) and Crosscarmellose (3,4%w/w) in different concentrations. In sublimation method, camphor was used as subliming agent along with different concentrations of crospovidone (2,4,6,8% w/w). The tablets thus prepared were evaluated for weight variation, hardness, friability, drug content uniformity, wetting time, water absorption ratio, in vitro dispersion time and in vitro dissolution studies. Short-term stability studies (40±2o/75±5% RH for 3 months) and drug-excipient interaction studies were performed for best formulation (invitro dispersion time less than 15secs for WG3 and SB3). In vitro dissolution study results showed that tablets prepared by sublimation technique showed faster drug release when compared to tablets prepared by wet granulation method (% drug release in 5mins 78.6 and 76.9 respectively). IR spectroscopic study results showed that there is no drug excipient interaction. Short-term stability studies on the best formulations showed that there are no significant changes in drug content and in vitro dispersion time (p<0.05).
Jitendra P.,Navabharat Institute of Pharmaceutical and Medical science |
Kumar G.S.,Gandhi Institute of Technology and Management |
Prasad P.U.,Navabharat Institute of Pharmaceutical and Medical science
Research Journal of Pharmacy and Technology | Year: 2011
A wide range of chemicals compound have been isolated from Eupatorium odoratum L. and used extensively for treatment of several diseases like diarrhoea, diuretic activity, wound healing, Antimycobacterial activity and insect repellant properties. This article includes the detailed exploration of phytochemicals and pharmacological aspect of Eupatorium odoratum L. © RJPT All right reserved.