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Bai N.,Northwest University, China | He K.,Herbalife International | Roller M.,Naturex SA | Lai C.-S.,National Kaohsiung Marine University | And 2 more authors.
Journal of Agricultural and Food Chemistry | Year: 2015

From the roots of Lepidium meyenii Walpers (Brassicaceae) have been isolated and identified 2 flavonolignans, tricin 4′-O-[threo-β-guaiacyl-(7″-O-methyl)-glyceryl] ether (1) and tricin 4′-O-(erythro-β-guaiacyl-glyceryl) ether (2), along with 11 other known compounds, tricin (3), pinoresinol (4), 4-hydroxycinnamic acid (5), guanosine (6), glucotropaeolin (7), desulfoglucotropaeolin (8), 3-hydroxybenzylisothiocyanate (9), malic acid benzoate (10), 5-(hydroxymethyl)-2-furfural (11), d-phenylalanine (12), and vanillic acid 4-O-β-d-glucoside (13). Structures were elucidated on the basis of NMR and MS data. Some isolates and previously isolated lepidiline B (14) were tested for cytotoxicity in a small panel of human cancer cell lines (Hep G2, COLO 205, and HL-60) and for anti-inflammatory activities in LPS-treated RAW 264.7 macrophage. Among them, compounds 1 and 14 were modestly active for inhibiting nitrite production in macrophage. Compounds 1, 14, and 3 were demonstrated to be selectively active against HL-60 cells with IC50 values of 40.4, 52.0, and 52.1 μM, respectively. © 2015 American Chemical Society.


Bai N.,Naturex Inc. | He K.,Naturex Inc. | Roller M.,Naturex SA | Lai C.-S.,National Kaohsiung Marine University | And 3 more authors.
Journal of Agricultural and Food Chemistry | Year: 2010

A new flavonoid, 6"-O-(E)-feruloylhomoplantaginin (1), and 14 known compounds, 6"-O-(E)-feruloylnepitrin (2), 6"-O-(E)-p-coumaroylnepitrin (3), 6-methoxyluteolin 7-glucopyranoside (4), luteolin 3'-O-β-d- glucuronide (5), luteolin 3'-O-(3"-O-acetyl)-β-d-glucuronide (6), kaempferol (7), luteolin (8), genkwanin (9), and ladanein (10), together with 1-O-feruloyl-β-d-glucopyranose (11), 1-O-(4-hydroxybenzoyl)-β-d- glucopyranose (12), rosmarinic acid (13), carnosic acid (14), and carnosol (15), were isolated from the leaves of Rosmarinus officinalis. The structures were established on the basis of NMR spectroscopic methods supported by HRMS. All isolated compounds were tested for cytotoxicity in human cancer cell lines (HepG2, COLO 205, and HL-60) and for anti-inflammatory activities in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells. Among them, compounds 14 and 15 were modestly active in the inhibition of nitrite production in macrophages, followed by compounds 8 and 5. Compounds 14 and 15 were more effective as an antiproliferative agent in HL-60 cells with IC 50 values of 1.7 and 5.5 μM, followed by compounds 8 and 7 with IC 50 of 39.6 and 82.0 μM, respectively. In addition, compounds 14 and 15 showed potent antiproliferative effects on COLO 205 cells with IC 50 values of 32.8 and 29.9 μM, respectively. © 2010 American Chemical Society.


Bai N.,Naturex Inc. | He K.,Naturex Inc. | Ibarra A.,Naturex Inc. | Bily A.,Naturex Inc. | And 4 more authors.
Journal of Natural Products | Year: 2010

Two new secoiridoid glucosides, excelsides A (1) and B (2), were isolated from the seeds of Fraxinus excelsior. Their structures were elucidated as (2S,4S,3E)-methyl 3-ethylidene-4-(2-methoxy-2-oxoethyl)-2-[(6-O-β-D- glucopyranosyl-β-D-glucopyranosyl)oxy]-3,4-dihydro-2H-pyran-5-carboxylate and (2S,4S,3E)-methyl 3-ethylidene-4-{2-[2-(4-hydroxyphenyl)ethyl]oxy-2- oxoethyl}-2-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-3, 4-dihydro-2H-pyran-5-carboxylate, respectively, on the basis of NMR and MS data. Eight known compounds were identified as nuzhenide (3), GI3 (4), GI5 (5), ligstroside (6), oleoside 11-methyl ester (7), oleoside dimethyl ester (8), 1‴-O-β-D-glucosylformoside (9), and salidroside (10). Compounds 1-9 inhibited adipocyte differentiation in 3T3-L1 cells. Dilutions of the aqueous extract of F. excelsior (1:10 000) as well as compounds 2, 3, 4, 5, and 8 activated the peroxisome proliferator-mediated receptor-α (PPARα) reporter cell system in the range of 10 -4 M, compared to 10 -7-10 -8 M for the synthetic PPARα activiator, WY14,643. Both biological activity profiles support the hypothesis that inhibition of adipocyte differentiation and PPARα-mediated mechanisms might be relevant pathways for the antidiabetic activity of F. excelsior extract. © 2010 American Chemical Society and American Society of Pharmacognosy.


A method of controlling body weight in humans by administering an amount of decaffeinated green coffee extract effective to treat a subject. A preferred green coffee extract contains a ratio of 4-caffeoylquinic acid (4-CQA) to total chlorogenic acids (tCGA) (5-CQA/tCGA) of from about 0.1 to about 0.2. More preferably, the green coffee extract comprises from about 6% to about 8% of 4-caffeoylquinic acid and has a total chlorogenic acid concentration that exceeds about 45%. A preferred method of administration consists of administering the green coffee extracts is a dosage of about 200 mg twice a day prior to meals on an empty stomach.


Disclosed are methods of enhancing neurocognitive function by administering of American

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