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Henry-Vitrac C.,University of Bordeaux Segalen | Ibarra A.,Naturex Inc. | Roller M.,Naturex SA Site D Agroparc | Merillon J.-M.,University of Bordeaux Segalen | Vitrac X.,University of Bordeaux Segalen
Journal of Agricultural and Food Chemistry | Year: 2010

Glucose-6-phosphatase (Glc-6-Pase) is a multicomponent system that exists primarily in the liver and catalyzes the terminal step in gluconeogenesis and glycogenolysis. Several studies have attempted to identify synthetic or natural compounds that inhibit this enzyme complex for therapeutic use in regulating blood glucose and type 2 diabetes. For this paper an in vitro structure?activity relationship study of several natural chlorogenic acids was conducted, and the active components of the natural decaffeinated green coffee extract Svetol were identified. Glucose-6-phosphate (Glc-6-P) hydrolysis was measured in the presence of Svetol or chlorogenic acids in intact human liver microsomes. Svetol significantly inhibited Glc-6-P hydrolysis in intact human liver microsomes in a competitive manner, and it was determined that chlorogenic acids (caffeoylquinic acids and dicaffeoylquinic acids) were the chief compounds mediating this activity. In addition, the structure?activity analysis showed that variation in the position of the caffeoyl residue is an important determinant of inhibition of Glc-6-P hydrolysis. This inhibition by Svetol contributes to its antidiabetic, glucose-lowering effects by reducing hepatic glucose production. © 2010 American Chemical Society.


Ibarra A.,Naturex Inc. | Cases J.,Naturex SA | Roller M.,Naturex SA | Chiralt-Boix A.,Polytechnic University of Valencia | And 2 more authors.
British Journal of Nutrition | Year: 2011

Rosemary (Rosmarinus officinalis L.) extracts (RE) are natural antioxidants that are used in food, food supplements and cosmetic applications; exert anti-inflammatory and anti-hyperglycaemic effects; and promote weight loss, which can be exploited to develop new preventive strategies against metabolic disorders. Therefore, the aim of the present study was to evaluate the preventive effects of rosemary leaf extract that was standardised to 20 % carnosic acid (RE) on weight gain, glucose levels and lipid homeostasis in mice that had begun a high-fat diet (HFD) as juveniles. The animals were given a low-fat diet, a HFD or a HFD that was supplemented with 500 mg RE/kg body weight per d (mpk). Physiological and biochemical parameters were monitored for 16 weeks. Body and epididymal fat weight in animals on the HFD that was supplemented with RE increased 69 and 79 % less than those in the HFD group. Treatment with RE was associated with increased faecal fat excretion but not with decreased food intake. The extract also reduced fasting glycaemia and plasma cholesterol levels. In addition, we evaluated the inhibitory effects of RE in vitro on pancreatic lipase and PPAR-γ agonist activity; the in vitro findings correlated with our observations in the animal experiments. Thus, the present results suggest that RE that is rich in carnosic acid can be used as a preventive treatment against metabolic disorders, which merits further examination at physiological doses in randomised controlled trials. © Copyright © The Authors 2011.


Trademark
Naturex Inc. | Date: 2014-09-30

Chemical additives in the form of raw materials for use in the manufacture of food; plant extracts for use in the manufacture of food; chemical products and plant extracts for preserving food; chemical products and plant extracts for use in the manufacture of food to improve the taste or aroma of food; aromatic substances, namely, aromatic hydrocarbons; aromatic oleoresin for use in the manufacture of foods and cosmetics. Flavorings other than essential oils; aromatic preparations for food, namely, spices and food flavorings.


Trademark
Naturex Inc. | Date: 2012-09-18

Pharmaceutical products containing bilberry extracts for medical purposes, namely, pharmaceuticals for the prevention and treatment of eye diseases and conditions, for the prevention and treatment of eyestrain, for the prevention and treatment of skin aging signs, damaged skin and tissues and for the prevention and treatment of eye aging troubles; phytotherapeutic products containing bilberry extracts for medical purposes, namely, herbal supplements; nutritional and dietetic supplements containing bilberry extracts for medical purposes; nutritional and dietetic supplements comprised of bilberry extracts in the form of capsules, tablets, medicated chewing gum, edible liquid and solid preparations, milk preparations, powders, powders for edible preparations, powders for beverage preparations, and medicated beverages; pharmaceutical products containing bilberry extracts, namely, medicines and phytomedicines for the prevention and treatment of eye diseases and conditions, for the prevention and treatment of eyestrain, for the prevention and treatment of skin aging signs, damaged skin and tissues and for the prevention and treatment of eye aging troubles.


Trademark
Naturex Inc. | Date: 2011-12-20

Soaps, perfumes, cosmetics, essential oils; natural essential oils, namely, raw aromatic oleoresin; cosmetics, namely, cosmetic products in all galenic forms not for medical purposes primarily comprised of plant extracts. Nutritional food additives, not for medical purposes, made from coffee, tea, cocoa, sugar, rice, tapioca, sago, pasta, and cereals; flavorings other than essential oils; aromatic preparations for food, namely, edible spices, processed herbs, flavor enhancers used in food products, extracts used as flavorings excluding essential oils; natural sweeteners; food essences excluding ethereal essences and essential oils, namely, coffee essences.


Trademark
Naturex Inc. | Date: 2011-12-20

Soaps, perfumes, cosmetics, essential oils; natural essential oils, namely, raw aromatic oleoresin; cosmetics, namely, cosmetic products in all galenic forms not for medical purposes primarily comprised of plant extracts. Nutritional food additives, not for medical purposes, made from coffee, tea, cocoa, sugar, rice, tapioca, sago, pasta, and cereals; flavorings other than essential oils; aromatic preparations for food, namely, edible spices, processed herbs, flavor enhancers used in food products, extracts used as flavorings excluding essential oils; natural sweeteners; food essences excluding ethereal essences and essential oils, namely, coffee essences.


Trademark
Naturex Inc. | Date: 2011-02-01

Food coloring for use in the preparation of food products and beverages. Non-medicated fruit and vegetable extracts for making food products; preserved and cooked fruits and vegetables; non-medicated dried, preserved, frozen and cooked fruit and vegetable extracts for use in making prepared meals or food; jellies and jams; fruit concentrates and vegetable concentrates for use as ingredients of foods; soups; margarines; processed, edible seaweeds; flavored desserts, namely, fruit salads, dehydrated fruit snacks, fruit-based spreads, milk curd; milk and dairy products, namely, creams, fresh cream, butter, vegetable mousses, cheese spreads, cheeses, fresh cheeses, yoghurts, drinking yoghurts, plain or flavored fermented dairy products, namely, plain or fermented dairy-based dips, plain or fermented dairy-based spreads; edible decorations for meat. Flavorings used in making food and beverages; sweet or savory biscuits; confectionery, fruit jellies being confectioneries, almond paste, chewing gums not for medical purposes, confectionery, namely, pastilles; breadcrumbs, preparations made for bread-crumbs, namely, breads; preparations made from cereals, namely, ready to eat food bars; pastries, cakes; sauces being condiments, salad dressings, starch-based binding agents for sauces, sauce bases, seasonings for soups and cooked dishes; topping syrups; treacle, starches for food; ice creams, water ices, sorbets, frozen confectionery; spices; edible cake decorations; icing mixes, sauces in the nature of edible glazes; flavored desserts, namely, flavored and sweetened gelatin desserts; cream desserts, namely, ice cream and cream puffs; dessert mousse; milk desserts, namely, ice milk. Fruit flavored concentrates and syrups for making soft drinks; extracts and essences, not essential oils, used in the manufacture of non-alcoholic soft drinks; mineral and aerated waters, flavored waters; soft drinks, namely, sodas; fruit beverages, namely, smoothies; syrups and powders for making beverages.


Trademark
Naturex Inc. | Date: 2012-05-15

Chemical products, namely, chemicals in the form of raw materials primarily comprising plant extracts for use in the manufacture of cosmetics, food and pharmaceuticals; active plant-based chemical ingredients used in cosmetic preparations. Nutritional supplements containing plant-based extracts and nutritional supplements containing plant-extracted purified molecules, intended for hair and nail beauty and care in the form of gelatin capsules, tablets, ampoules, yeast, powders and bars for cosmetic use; none of the above for skin care or acne care. Nutritional food additives, not for medical purposes, made from coffee, tea, cocoa, sugar, rice, tapioca, sago, pasta, and cereals; flavorings other than essential oils; aromatic preparations for food, namely, spices, dried herbs, processed herbs, herb salt; natural sweeteners; food essences excluding ethereal essences and essential oils, namely, coffee essences.


Trademark
Naturex Inc. | Date: 2012-01-17

Chemical products, namely, chemicals in the form of raw materials primarily comprising plant extracts for use in the manufacture of cosmetics, food and pharmaceuticals; active plant-based chemical ingredients used in cosmetic preparations. Soaps, perfumes, cosmetics, essential oils; natural essential oils, namely, raw aromatic oleoresin; cosmetics, namely, cosmetic products in all galenic forms not for medical purposes primarily comprised of plant extracts; mineral salt in the nature of bath salts not for medical purposes. Nutritional supplements containing plant-based extracts and plant-extracted purified molecules, intended for skin, body, face, hair and nail beauty and care in the form of gelatin capsules, tablets, ampoules, yeast, powders, bars, and beverages for cosmetic use; nutritional supplements containing plant extracts. Nutritional food additives, not for medical purposes, made from cocoa, sugar, rice, tapioca, sago, pasta, and cereals; flavorings other than essential oils; aromatic preparations for food, namely, spices, dried herbs, processed herbs, herb salt; natural sweeteners.


Trademark
Naturex Inc. | Date: 2011-02-08

Plant extract sold as an integral component of dietary and nutritional supplements in the nature of capsules and pills; plant extracts sold as an integral component of nutritional supplements, dietetic substances, namely, dietetic foods adapted for medical use, dietetic sugar and dietary supplemental drinks; medicinal herb extracts sold as an integral component of nutritional supplements, dietetic substances, namely, dietetic foods adapted for medical use, dietetic sugar and dietary supplemental drinks.

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