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Mishra B.,Natural Remedies Pvt. Ltd
Journal of Natural Remedies | Year: 2012

Nutraceutical, a portmanteau of the words "nutrition" and "pharmaceutical", is a food or food product that reportedly provides health and medical benefits, including the prevention and treatment of disease. Based on various aspects we may understand that "Nutraceutical is a product isolated or purified from foods that is generally sold in medicinal forms not usually associated with food. A nutraceutical is demonstrated to have a physiological benefit or provide protection against chronic disease." Such products may range from isolated nutrients, dietary supplements and specific diets to genetically engineered foods, herbal products, and processed foods such as cereals, soups, and beverages. With recent developments in cellular-level nutraceutical agents, researchers, and medical practitioners are developing templates for integrating and assessing information from clinical studies on complementary and alternative therapies into responsible medical practice. In this review article, multifocal aspects of the nutraceutical, their usages and regulatory status in European Union are discussed.


Vikrama Chakravarthi P.,Natural Remedies Pvt. Ltd | Balaji S.N.,Natural Remedies Pvt. Ltd
Veterinary World | Year: 2010

In the recent years the application of nanotechnology in human and veterinary medicine has shown a great progress. Scientists foresee that this progress in the field of nanotechnology could represent a major breakthrough in addressing some of the technical challenges faced by human and veterinary profession.While the great hopes of nanomedicine are disease detection and new pharmaceuticals for humans, veterinary applications of nanotechnology may become the proving ground for untried and more controversial techniques from nanocapsule vaccines to sex selection in breeding. Nanotechnology has the potential to impact not only the way we live, but also the way we practice veterinary medicine.Examples of potential applications in animal agriculture and veterinary medicine include disease diagnosis and treatment delivery systems, new tools for molecular and cellular breeding, the security of animal food products, modification of animal waste, pathogen detection, and many more. Existing research has demonstrated the feasibility of introducing nanoshells and nanotubes into animals to seek and destroy targeted cells. These building blocks of nanotechnology are expected to be integrated into systems over the next couple of decades on a commercial basis. This article describes some of the principal areas of nanotechnology currently being undertaken in the world of medicine. The main purposes of this article are to trigger the interest of discoveries of veterinary profession in the field of nanotechnology and to provide a glimpse at potential important targets for nanotechnology in the field of veterinary medicine. Also it is important to mention that because nanotechnology is at a very early stage of development, it may take several years to perform the necessary research and conduct clinical trials for obtaining meaningful results.This tool as it develops over the next several decades will have major implications in veterinary and animal science.


Velusami C.C.,Natural Remedies Pvt. Ltd. | Velusami C.C.,Vellore Institute of Technology | Agarwal A.,Natural Remedies Pvt. Ltd. | Mookambeswaran V.,Vellore Institute of Technology
Evidence-based Complementary and Alternative Medicine | Year: 2013

N. nucifera is one among the important medicinal plants assessed for its antiobesity action in various preclinical models. The present study was aimed at investigating the antiobesity effect of methanol and successive water extracts of petals of N. nucifera by studying its effect on adipogenesis, adipolysis, lipase, serotonin (5-HT2C), cannabinoid (CNR2), melanocyte concentrating hormone (MCHR1), and melanocortin (MC4R) receptors. Both methanol and successive water extracts of N. nucifera petals had an effect on inhibition of lipid storage in adipocytes and on increasing lipolysis. N. nucifera petal methanol extract exhibited the concentration- dependent inhibitory effect on lipase activity with an IC50 value of 47 μg/mL. N. nucifera petal extracts showed evident agonist and antagonist activity towards 5-HT2C and CNR2 receptors, respectively, while it showed no effect towards MCHR1 and MC4R receptors. Overall, methanol extract of N. nucifera petals showed better activity than successive water extract. © 2013 Chandrasekaran Chinampudur Velusami et al.


Chandrasekaran C.V.,Natural Remedies Pvt. Ltd. | Gupta A.,Natural Remedies Pvt. Ltd. | Agarwal A.,Natural Remedies Pvt. Ltd.
Journal of Ethnopharmacology | Year: 2010

Aim of study: Andrographis paniculata has been known to possess widespread traditional application in the treatment of allergy and inflammatory diseases. In the current study, we sought to examine the effects of an extract of Andrographis paniculata leaves on inhibition of lipopolysaccharide (LPS) induced [nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-1beta (IL-1 beta), and interleukin-6 (IL-6)] and calcimycin (A23187) induced [leukotriene B4 (LTB4), thromboxane B2 (TXB2) and histamine] mediators in diverse cell based models. Materials and methods: Effect of an extract of Andrographis paniculata leaves (AP) was studied on inhibition of LPS induced NO, PGE2, IL-1 beta and IL-6 in J774A.1 murine macrophages; A23187 induced LTB4 and TXB2 in HL-60 promyelocytic leukemic cells and histamine in RBL-2H3 rat basophilic leukemia cells. Results and conclusion: AP illustrated significant alleviation of pro-inflammatory, inflammatory, and allergic mediators. However, no inhibition was observed against histamine release. This outcome has been summed up to deduce that AP is fairly potent in attenuating the inflammation by inhibiting pro-inflammatory (NO, IL-1 beta and IL-6), inflammatory (PGE2 and TXB2) and allergic (LTB4) mediators. © 2010 Elsevier Ireland Ltd.


Thiyagarajan P.,Natural Remedies Pvt. Ltd | Chandrasekaran C.V.,Natural Remedies Pvt. Ltd | Deepak H.B.,Natural Remedies Pvt. Ltd | Agarwal A.,Natural Remedies Pvt. Ltd
Inflammopharmacology | Year: 2011

Objective: To evaluate the inhibitory property of de-glycyrrhizinated extract of Glycyrrhiza glabra root and its phytoconstituents (glabridin, isoliquiritigenin and glycyrrhizin) on LPS-induced production of pro-inflammatory mediators. Materials and methods: Inhibitory effect of G. glabra extract and its phytoconstituents were studied on lipopolysaccharide (LPS)-induced nitric oxide (NO), interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) levels in J774A.1 murine macrophages. Results: G. glabra and isoliquiritigenin significantly inhibited LPS stimulated NO, IL-1 beta and IL-6 production. Glabridin showed significant inhibition of NO and IL-1 beta release, but failed to attenuate IL-6 levels at the tested concentrations. In addition, glycyrrhizin did not exhibit inhibitory response towards any of the LPS-induced pro-inflammatory mediators at the tested concentrations. Conclusion: From the results we speculate that the inhibitory effect of G. glabra extract on LPS-induced pro-inflammatory mediators is influenced by glabridin and isoliquiritigenin and is not contributed by glycyrrhizin. © 2011 Springer Basel AG.


Kumar R.,All India Institute of Medical Sciences | Gupta Y.K.,All India Institute of Medical Sciences | Singh S.,All India Institute of Medical Sciences | Arunraja S.,Natural Remedies Pvt. Ltd
Phytotherapy Research | Year: 2016

The present study investigates the anti-arthritic activity of Picrorhiza kurroa (PK), on formaldehyde and adjuvant-induced arthritis (AIA) in rat. Administration of Picrorhiza kurroa rhizome extract (PKRE) significantly inhibited joint inflammation in both animal models. In AIA-induced arthritic rat, treatment with PKRE considerably decreased synovial expression of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor receptor-1 (TNF-R1) and vascular endothelial growth factor as compared with control. The anti-arthritic activity was found to be well substantiated with significant suppression of oxidative and inflammatory markers as there was decreased malonaldehyde, Nitric oxide, tumor necrosis factor alpha levels accompanied with increased glutathione and superoxide dismutase, catalase activities. Additionally, PKRE significantly inhibited the expression of degrading enzymes, matrix metalloproteinases-3 and matrix metalloproteinases-9 in AIA-induced arthritic rat. Histopathology of paw tissue displayed decreased inflammatory cell infiltration as compared with control. Taken together, these results demonstrated the anti-arthritic activity of PKRE against experimental arthritis, and the underlying mechanism behind this efficacy might be mediated by inhibition of inflammatory mediators and angiogenesis, improvement of the synovium redox status and decreased expression of matrix metalloproteinases. © 2015 John Wiley & Sons, Ltd.


Agarwal A.,Natural Remedies Pvt. Ltd. | D'Souza P.,Natural Remedies Pvt. Ltd. | Johnson T.S.,Natural Remedies Pvt. Ltd. | Dethe S.M.,Natural Remedies Pvt. Ltd. | Chandrasekaran C.V.,Natural Remedies Pvt. Ltd.
Current Opinion in Biotechnology | Year: 2014

In vitro bio assays can play a vital role in evaluating botanicals ranging from comparative screening, interaction studies, bio-activity guided fractionation, biological characterization, assisting in stability studies to studying mechanism of actions. In this review, we present some challenges and common pitfalls of using bioassays for assessing botanicals including guidance to overcome them. The overall objective of this review is to improve the success of botanicals products by incorporating robust bioassays during various stages of research and development. © 2013 Elsevier Ltd.


Mehla J.,All India Institute of Medical Sciences | Pahuja M.,All India Institute of Medical Sciences | Dethe S.M.,Natural Remedies Pvt. Ltd. | Agarwal A.,Natural Remedies Pvt. Ltd. | Gupta Y.K.,All India Institute of Medical Sciences
Neurochemistry International | Year: 2012

Evolvulus alsinoides, also known as Shankpushapi, is a commonly used traditional medicine for enhancing memory. We evaluated the in vitro free radical scavenging and enzymes [acetylcholinesterase, butyrylcholinestrase, glycogen synthase kinase-3-β (GSK-3-β), rho kinase (ROCK II), prolyl endopeptidase (PEP), catechol-O-methyl transferase (COMT) and lipoxygenase (LOX)] inhibitory activities of aqueous and hydro-alcoholic extracts of E. alsinoides. Hydro-alcoholic extract of E. alsinoides demonstrated more free radical scavenging activity as compared to aqueous extract. Hydro-alcoholic extract also showed higher cholinesterase, GSK-3-β, ROCK II, PEP, COMT and LOX enzyme inhibitory activities as compared to aqueous extract. Phytochemical analysis revealed more flavanoids in hydro-alcoholic extract as compared to aqueous extract but no significant difference in phenolic content of the two extracts was observed. Based on in vitro data, hydro-alcoholic extract (100, 300 and 500 mg/kg, p.o.) was selected for in vivo study in intracerebroventricularly injected streptozotocin (STZ) induced cognitive impairment in male Wistar rats. Elevated plus maze, passive avoidance and Morris water maze were used for assessment of cognitive function on 14th, 21st and 28th day after STZ injection. Oxidative stress parameters (malondialdehyde, reduced glutathione, nitric oxide levels and superoxide dismutase activity), cholinergic dysfunction and rho kinase (ROCK II) expression were studied in cerebral cortex and hippocampus of rat brain at the end of the study. Hydro-alcoholic extract of E. alsinoides dose dependently prevented STZ induced cognitive impairment by reducing the oxidative stress, improving cholinergic function and preventing the increase in rho kinase expression. The results suggest an anti-Alzheimer potential of hydro-alcoholic extract of E. alsinoides. © 2012 Elsevier Ltd. All rights reserved.


Patent
Natural Remedies Pvt Ltd. | Date: 2012-08-24

The present invention provides a synergistic phytochemical composition from Curcuma longa possessing analgesic and anti inflammatory activity used for management of chronic pain and treatment of osteoarthritis. The composition comprises Curcuma longa oil and Curcuma longa water extract. The relative amounts of these materials may be 0.5-5% by weight and 95-99.5% by weight respectively; and optionally pharmaceutically acceptable excipients. The present invention also provides a process for preparing the composition.


Chandrasekaran C.V.,Natural Remedies Pvt. Ltd. | Thiyagarajan P.,Natural Remedies Pvt. Ltd. | Deepak H.B.,Natural Remedies Pvt. Ltd. | Agarwal A.,Natural Remedies Pvt. Ltd.
International Immunopharmacology | Year: 2011

The aim of the current study is to probe the anti-inflammatory/anti- allergic potential of seven phytoconstituents (andrographolide, neoandrographolide, isoandrographolide, andrograpanin, 14-deoxy-11,12- didehydroandrographolide, 7-O-methylwogonin and skullcapflavone-I) isolated from Andrographis paniculata (King of bitters) on the production of key inflammatory/allergic mediators (NO, PGE2, IL-1 beta, IL-6, LTB 4, TXB2 and histamine). The results demonstrated that andrographolide, isoandrographolide, 7-O-methylwogonin and skullcapflavone-I significantly inhibited LPS stimulated NO and PGE2 release in J774A.1 macrophages. Andrographolide, isoandrographolide and 7-O-methylwogonin showed considerable inhibition of IL-1 beta production in LPS elicited macrophages. LPS induced IL-6 production was significantly inhibited by andrographolide, isoandrographolide and skullcapflavone-I in a concentration dependent manner. The results revealed that andrographolide, isoandrographolide and skullcapflavone-I significantly decreased TXB2 release in A23187 activated HL-60 promyelocytic cells. Furthermore, the anti-allergic properties of the phytoconstituents was investigated on A23187 induced LTB4 production (HL-60 cells) and histamine release (RBL-2H3 basophilic cells). The results showed that only skullcapflavone-I and 7-O-methylwogonin showed marked inhibitory effect on LTB4 production, however, only 7-O-methylwogonin exerted dose-dependent inhibition towards histamine release. Therefore, this study indicates that some of these phytoconstituents exhibit potent anti-inflammatory/anti-allergic effects by modulating different inflammatory/allergic mediators. Hence, these phytoconstituents might provide useful phytomedical treatment against variety of inflammatory and allergic disorders. © 2010 Elsevier B.V. All rights reserved.

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