Bangalore, India
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Jamwal R.,Natural Remedies Private Ltd | Dethe S.,Natural Remedies Private Ltd
Journal of Sexual Medicine | Year: 2014

Introduction: Herbs have been used as an aphrodisiac since ages. Cinnamomum cassia is an important ingredient of many Ayurvedic formulations to treat male sexual disorder including erectile dysfunction (ED). Aim: The objective of the present study was to evaluate erectogenic and aphrodisiac activity of methanol extract of C. cassia bark in young male rats. Methods: Methanol extract of C. cassia was screened in vitro for arginase inhibition potential and IC50 was determined. Effect of the extract was observed in vitro on phenylephrine pre-contracted isolated rat corpus cavernosum smooth muscle (CCSM) at 0.1, 1, 10, and 100μg/mL. Young male Wistar rats were dosed with extract at 100 mg/kg body weight for 28 days and its effects on sexual behavior and penile smooth muscle : collagen level were observed. Main Outcome Measure: Effect of C. cassia was studied on arginase activity in vitro and sexual behavior of young male rats. Results: C. cassia inhibited arginase activity in vitro with an IC50 of 61.72±2.20μg/mL. The extract relaxed phenylephrine pre-contracted isolated rat CCSM up to 43% and significantly increased (P<0.05) sexual function of young male rats. Treatment with the extract also increased smooth muscle level and decreased collagen level in rat penile tissue. Conclusion: The study proves usefulness of methanol extract of C. cassia bark for increasing sexual function. © 2014 International Society for Sexual Medicine.


Sreeram D.C.,Natural Remedies Private Ltd | Vedamurthy A.B.,Karnataka University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

To develop the finger print of medicinally and economically important plant of Coriandrum sativum Linn[Family: Apiceae]. Different extracts of fresh leaves and dried fruits of C. sativum were developed in the mobile phase of Toluene: ethyl acetate: formic acid::45:5:1 using standard procedure[10μl] and scanned under UV at 254 nm and 366 nm. The HPTLC fingerprinting of he different extract have shown several peaks with different Rf values. Petroleum ether extract of fresh leaves[maceration] and dried fruit [Soxhlation and maceration] has shown 5, 9 and 10 compounds; benzene extract showed 10,9 and 7 compounds; chloroform extract showed 8,8 and 9 compounds; methanol extracts showed 7,6 and 9 compounds; ethanol extracts showed 7,6, and 14 compounds and water extracts sowed 6,9 and 7 compounds respectively. It can be concluded that HPTLC fingerprint analysis of leave and fruit extract of Coriandrum sativum can be used as a diagnostic tool for the correct identification of the plant and it is useful as a phytochemical marker.


PubMed | Olive LifeSciences Pvt. Ltd., Natural Remedies Private Ltd and Indian Institute of Science
Type: Journal Article | Journal: In silico pharmacology | Year: 2016

Piper nigrum [Piperaceae], commonly known as black pepper is used as medicine fairly throughout the greater part of India and as a spice globally.To isolate piperine and evaluate in vitro cytotoxic [antiproliferative] activity and in silico method.Piperine was isolated from the fruits of P.nigrum. Piperine was characterized by UV,IR, (1)H-NMR, (13)C-NMR and Mass spectrum. Standardization of piperine was done also by HPTLC fingerprinting. In vitro cytotoxic activity was done using HeLa cell lines by MTT assay at different concentrations ranging from 20 to 100g/ml in triplicate and in silico docking studies using enzyme EGFR tyrosine kinase.Fingerprinting of isolated piperine were done by HPTLC method. The IC50 value was found to be 61.940.054g/ml in in vitro cytotoxic activity in HeLa Cell lines. Piperine was subjected to molecular docking studies for the inhibition of the enzyme EGFR tyrosine kinase, which is one of the targets for inhibition of cancer cells. It has shown -7.6kJmol(-1) binding and 7.06kJmol(-1) docking energy with two hydrogen bonds.piperine has shown to possess in vitro cytotoxic activity and in silico studies.


PubMed | Natural Remedies Private Ltd
Type: | Journal: Fitoterapia | Year: 2013

Bacopa monnieri is fast gaining popularity for its beneficial effects on cognition and memory. The active constituents of the plant were putatively identified as bacosides A and B in older publications. Subsequently bacoside A was identified as a mixture of four saponins [bacoside A3 (1), bacopaside II (2), bacopasaponin C (3) and the jujobogenin isomer of the latter (4)] and was considered as part of major constituents of the herb along with bacopaside I (5). These major saponins now form part of analytical monographs in many Pharmacopoeia. However identity of bacoside B still appears controversial with seemingly contradictory information available in the scientific literature. At the same time quality of many extracts and herbal products derived from the plant is still being determined based on the content of bacosides A and B. We have elaborated these issues in this article along with our recommendations to move forward towards achieving scientific clarity on the subject.


Trademark
Natural Remedies Private Ltd | Date: 2012-01-31

MEDICINAL HERB EXTRACTS.


Trademark
Natural Remedies Private Ltd | Date: 2012-01-31

MEDICINAL HERB EXTRACTS.


PubMed | Natural Remedies Private Ltd
Type: Journal Article | Journal: Journal of dietary supplements | Year: 2016

Flavonoid-rich extract prepared from Glycyrrhiza glabra has been found to be beneficial in patients with functional dyspepsia and was reported to possess some gut health-promoting properties such as antioxidant, anti-inflammatory and anti-Helicobacter pylori activities. In the present study, the flavonoid-rich extract of Glycyrrhiza glabra was evaluated for its compatibility with probiotic strains (Lactobacillus casei, Lactobacillus fermentum, Lactobacillus plantarum, and Streptococcus thermophilus), commercial probiotic drinks, and digestive enzymes (pancreatic -amylase, -glucosidase, phytase, xylanase, and pancreatic lipase). Results of this study indicated that the flavonoid-rich extract of Glycyrrhiza glabra is compatible with the tested probiotic strains, probiotic drinks and digestive enzymes.


Trademark
Natural Remedies Private Ltd | Date: 2012-01-31

Medicinal herbal extracts.


Trademark
Natural Remedies Private Ltd | Date: 2012-01-31

Food supplements, dietary supplements, nutraceuticals for use as dietary supplements, medicinal herb extracts.


Trademark
Natural Remedies Private Ltd | Date: 2013-01-08

Botanical ingredients, namely, botanical extracts for medical purposes and as nutraceuticals for use as a dietary supplement; dietary and nutritional supplements; nutritional additives for medical purposes for use in foods and dietary supplements for human consumption; dietary supplements containing extracts from turmeric; medicinal herbal extracts for medical purposes; medicines for pain management.

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