Natural Remedies Private Ltd

Bangalore, India

Natural Remedies Private Ltd

Bangalore, India
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Richard E.J.,Natural Remedies Private Ltd | Murugan S.,Natural Remedies Private Ltd | Bethapudi B.,Natural Remedies Private Ltd | Illuri R.,Natural Remedies Private Ltd | And 2 more authors.
Toxicology Reports | Year: 2017

Andrographis paniculata, “King of bitters” is a popularly known medicinal plant extensively used in many parts of the world for treatment of various diseases. Since recent past, anaphylactic/allergic type adverse events were reported upon A. paniculata usage, the study aimed to evaluate the anaphylactic and anaphylactoid potential of A. paniculata extract and andrographolide (a major phytoactive of A. paniculata). The anaphylactic potential was evaluated using active systemic anaphylaxis (ASA) assay in guinea pigs. Further, the release of allergic mediators was measured in immunoglobulin E (IgE) sensitized and non-IgE sensitized Rat Basophilic Leukemia (RBL-2H3) cell lines in-vitro. A. paniculata extract or andrographolide sensitized guinea pigs following the challenge antigen administration orally and intravenously did not demonstrate any clinical signs of anaphylaxis. IgE sensitized and non- IgE sensitized RBL-2H3 cells treated with A. paniculata extract did not induce release of allergic mediators. Whereas IgE sensitized and non- IgE sensitized RBL-2H3 cells treated with andrographolide demonstrated mild to moderate release of allergic mediators. A. paniculata extract has no anaphylactic and anaphylactoid potential in in-vivo and in-vitro studies. Whereas, andrographolide effects on allergic mediators in in-vitro studies needs to be scrutinized if they are of biologically important. © 2017 The Authors


Manoj Kumar P.,Natural Remedies Private Ltd | Jamwal R.,Natural Remedies Private Ltd | Dethe S.,Natural Remedies Private Ltd | Agarwal A.,Natural Remedies Private Ltd
Journal of Ethnopharmacology | Year: 2012

The aim of the study: Activation of Rho-kinase 2 (ROCK-II) results in contraction of corpus cavernosum smooth muscle and ROCK-II inhibitors relax corpus cavernosum in vitro and in vivo hence, plant extracts capable of inhibiting ROCK-II enzyme may be useful in management of erectile dysfunction (ED). The aim of the study was to screen selected Indian medicinal plants, having similar ethnopharmacological use for ROCK-II inhibition. Materials and methods: Some Indian medicinal plants reported as aphrodisiacs in Ayurveda and modern scientific literature were collected, authenticated and extracted. Direct methanol and successive aqueous extracts of these plants were screened for ROCK-II inhibitory activity using HTRFR KinEASE™ STK S2 Kit (Cisbio Bioassays). Relaxant effect of potent extract was recorded on isolated rat corpus cavernosum. Results: Methanolic and successive aqueous extracts of 30 plants were screened for ROCK-II inhibition and 15 herbal extracts showed inhibition ranging between 50 and 88% at 50 μg/mL. While IC50 of Y-27632, a standard ROCK-II inhibitor, was found to be 163.8±1.2 nM. The Methanolic extract of Terminalia chebula (METC) with IC50 value of 6.09±0.17 μg/mL was found to be most potent and relaxed isolated rat corpus cavernosum significantly (p<0.01). Chebulagic and chebulinic acid of METC were found to inhibit ROCK-II and might be responsible for the inhibitory potential of the extract. The traditional use of plants like Butea frondosa, Syzygium aromaticum, Butea superba, Chlorophytum borivilianum and Mucuna pruriens, as aphrodisiacs and for male sexual disorder (MSD) might be in part due to the ROCK II inhibitory potential of these plants. Conclusion: Some of the Indian medicinal plants have ROCK-II inhibitory potential and those deserve further investigation. © 2012 Elsevier Ireland Ltd.


Jamwal R.,Natural Remedies Private Ltd | Dethe S.,Natural Remedies Private Ltd
Journal of Sexual Medicine | Year: 2014

Introduction: Herbs have been used as an aphrodisiac since ages. Cinnamomum cassia is an important ingredient of many Ayurvedic formulations to treat male sexual disorder including erectile dysfunction (ED). Aim: The objective of the present study was to evaluate erectogenic and aphrodisiac activity of methanol extract of C. cassia bark in young male rats. Methods: Methanol extract of C. cassia was screened in vitro for arginase inhibition potential and IC50 was determined. Effect of the extract was observed in vitro on phenylephrine pre-contracted isolated rat corpus cavernosum smooth muscle (CCSM) at 0.1, 1, 10, and 100μg/mL. Young male Wistar rats were dosed with extract at 100 mg/kg body weight for 28 days and its effects on sexual behavior and penile smooth muscle : collagen level were observed. Main Outcome Measure: Effect of C. cassia was studied on arginase activity in vitro and sexual behavior of young male rats. Results: C. cassia inhibited arginase activity in vitro with an IC50 of 61.72±2.20μg/mL. The extract relaxed phenylephrine pre-contracted isolated rat CCSM up to 43% and significantly increased (P<0.05) sexual function of young male rats. Treatment with the extract also increased smooth muscle level and decreased collagen level in rat penile tissue. Conclusion: The study proves usefulness of methanol extract of C. cassia bark for increasing sexual function. © 2014 International Society for Sexual Medicine.


PubMed | Olive LifeSciences Pvt. Ltd., Natural Remedies Private Ltd and Indian Institute of Science
Type: Journal Article | Journal: In silico pharmacology | Year: 2016

Piper nigrum [Piperaceae], commonly known as black pepper is used as medicine fairly throughout the greater part of India and as a spice globally.To isolate piperine and evaluate in vitro cytotoxic [antiproliferative] activity and in silico method.Piperine was isolated from the fruits of P.nigrum. Piperine was characterized by UV,IR, (1)H-NMR, (13)C-NMR and Mass spectrum. Standardization of piperine was done also by HPTLC fingerprinting. In vitro cytotoxic activity was done using HeLa cell lines by MTT assay at different concentrations ranging from 20 to 100g/ml in triplicate and in silico docking studies using enzyme EGFR tyrosine kinase.Fingerprinting of isolated piperine were done by HPTLC method. The IC50 value was found to be 61.940.054g/ml in in vitro cytotoxic activity in HeLa Cell lines. Piperine was subjected to molecular docking studies for the inhibition of the enzyme EGFR tyrosine kinase, which is one of the targets for inhibition of cancer cells. It has shown -7.6kJmol(-1) binding and 7.06kJmol(-1) docking energy with two hydrogen bonds.piperine has shown to possess in vitro cytotoxic activity and in silico studies.


Trademark
Natural Remedies Private Ltd | Date: 2012-01-31

MEDICINAL HERB EXTRACTS.


Trademark
Natural Remedies Private Ltd | Date: 2012-01-31

MEDICINAL HERB EXTRACTS.


PubMed | Natural Remedies Private Ltd
Type: Journal Article | Journal: Journal of dietary supplements | Year: 2016

Flavonoid-rich extract prepared from Glycyrrhiza glabra has been found to be beneficial in patients with functional dyspepsia and was reported to possess some gut health-promoting properties such as antioxidant, anti-inflammatory and anti-Helicobacter pylori activities. In the present study, the flavonoid-rich extract of Glycyrrhiza glabra was evaluated for its compatibility with probiotic strains (Lactobacillus casei, Lactobacillus fermentum, Lactobacillus plantarum, and Streptococcus thermophilus), commercial probiotic drinks, and digestive enzymes (pancreatic -amylase, -glucosidase, phytase, xylanase, and pancreatic lipase). Results of this study indicated that the flavonoid-rich extract of Glycyrrhiza glabra is compatible with the tested probiotic strains, probiotic drinks and digestive enzymes.


Trademark
Natural Remedies Private Ltd | Date: 2012-01-31

Medicinal herbal extracts.


Trademark
Natural Remedies Private Ltd | Date: 2012-01-31

Food supplements, dietary supplements, nutraceuticals for use as dietary supplements, medicinal herb extracts.


Trademark
Natural Remedies Private Ltd | Date: 2013-01-08

Botanical ingredients, namely, botanical extracts for medical purposes and as nutraceuticals for use as a dietary supplement; dietary and nutritional supplements; nutritional additives for medical purposes for use in foods and dietary supplements for human consumption; dietary supplements containing extracts from turmeric; medicinal herbal extracts for medical purposes; medicines for pain management.

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