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Rio de Janeiro, Brazil

Bhattacharya A.K.,Natural Product Chemistry Laboratory | Rana K.C.,Natural Product Chemistry Laboratory
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2013

Chemical examination of aerial parts of the plant, Lagascea mollis has resulted in the isolation of two compounds, an acyclic diteipene alcohol which has been identified as (£)-phytol 1 and lauric amide 3. Their structures have been elucidated by spectral data and chemical transformations. This is the first report of isolation of both these compounds from this plant. It is noteworthy that compound 1 has been found to be a potent antimycobacterial agent and thus, L. mollis could be exploited as an alternative source.

De Souza M.O.,State University of Feira de Santana | de Souza C.L.M.,State University of Feira de Santana | Pelacani C.R.,State University of Feira de Santana | Soares M.,Natural Product Chemistry Laboratory | And 4 more authors.
South African Journal of Botany | Year: 2013

Physalis angulata is a medicinal plant with valuable pharmacological activities. The physiology of stress in this plant can play an important role in the induction or maximization of the production of physalin F, B, D and G, bioactive secondary metabolites described as immunosuppressive, anti-malarial and anti-leishmanial agents. P. angulata was cultivated from seeds which had been previously primed in PEG 6000 solution and non-primed seeds. After 45. days, the plants were exposed to water restriction and saline stress in the field for 13. days. Seedling emergence and growth after stress treatment were assessed. Seco-steroids were quantified in leaves and stems by HPLC/PDA. The emergence rate was 14% higher in primed seeds. The types of irrigation proved to have a significant influence on the number of leaves and fruits, plant height and stem diameter, irrespective of whether the seeds were primed or not. The biomass of the fruits, stems and roots was also decreased by water restriction and saline stress. Physalin content in ethanol extracts increased in leaves, mainly after saline stress and from primed seeds. Despite the biomass reduction caused by the treatments, stress application led to an increase in the production of bioactive metabolites. © 2013 South African Association of Botanists.

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