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Zhou J.,Hunan Agricultural University | Zhou J.,Hunan University | Li S.-X.,Hunan Agricultural University | Li S.-X.,Hunan University | And 7 more authors.
Zhongguo Zhongyao Zazhi | Year: 2013

Objective: To compare the contents of stilbenes in different parts and axial root bark of mulberry, and study their correlation. Method: The contents of 3 major stilbenes, mulberroside A, oxyresveratrol, and resveratrol in different parts of mulberry were determined by HPLC. The correlation and regression analysis between the contents of stilbenes in the different parts and axial root bark was carried out. Result: The contents of stilbenes in most different parts of mulberry showed significant correlation. Between the contents of stilbenes in the different parts and axial root bark, oxyresveratrol showed significant correlation among all different parts, resveratrol showed significant correlation except in spinal cord of annual branch, mulberroside A showed significant correlation between bark of annual branch, lateral root and axial root bark. The results of the correlation and regression analysis indicated that the contents of mulberroside A, oxyresveratrol, resveratrol in different parts and axial root bark were significant positively correlated. Conclusion: The contents of stilbenes are significant correlation distributed in different parts and axial root bark of mulberry. The contents of stilbenes in different parts could be used to estimate the content of the axial root bark. The result could be useful for breeding and preserving excellent germplasm at the system breed process for mulberry of rich in stilbenes. Source


Li Z.-W.,Natsource Chemicals Changsha Corporation | Li Z.-W.,Changsha University of Science and Technology | Bao Z.-C.,Natsource Chemicals Changsha Corporation | Wang J.-N.,Natsource Chemicals Changsha Corporation | And 4 more authors.
Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities | Year: 2013

Diabetes has become the third major diseases threat to human's health and safety after cancer, cardiovascular and cerebrovascular diseases. The currently used drugs are difficult to completely cure the disease, and the long-term use is easy to produce side effects and drug resistance. So, it is very important to research and development a new kind of drug to treat the diabetes. The extract of gardenia and fruit containing the active ingredient genipin showed a very good effect in the traditional Chinese medicine treating the diabetes. In order to find novel anti-diabebes molecules, two core compounds containing amine group were synthesized from the commercial available genipin by methylation(benzylation), substitution with methylsulfonyl chloride followed by sodium azide and reduction. Thirteen novel compounds were obtained by reacting the two core compounds with a variety of acyl chlorides. The total yields were between 41% and 63%. Their structures were characterized by NMR, ESI-MS and elemental analysis and anti-dibiatic activities were evaluated by DPP IV assay at a concentration of 10 mmol/L. The results showed that all the title compounds exhibited certain extent inhibitory activities against DPP IV. Among them, compound 10f showed higher inhibitory rate up to 31.2%. Source

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