Taipei, Taiwan

National Yang-Ming University is a research university located in Shipai, Beitou District, Taipei, Taiwan. It is famous for research in fields of Medicine, Life science and Biotechnology. In the 2010 QS Asian Universities Rankings, Yang Ming University was placed 4th among universities in Taiwan and 2nd in the field of Life Science & Biomedicine.Yang-Ming is named after the Chinese philosopher Wang Yangming. Wikipedia.


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Patent
National Yang Ming University | Date: 2015-11-27

A dual targeting drug carrier is provided. The dual targeting drug carrier comprises a first targeting molecule and a second targeting molecule, wherein the targeting molecule comprises peptide, protein or antibody. The targeting molecule can bind to specific receptors, proteins, or glycoproteins to recognize the specific tumor cells, tissues, or organs. The dual targeting drug carriers are further conjugated with imaging agents, radioactive molecules (radiopharmaceuticals, isotopes, or chemotherapeutic drugs) or nanoparticles to form a conjugate


Patent
National Yang Ming University and National Taiwan University | Date: 2016-02-04

The present invention relates to novel TMPK inhibitor and their methods of use. In particular, it relates to novel TMPK inhibitor of Formula (I) and therapeutics that decrease the cellular dTTP level to suppress the growth and inhibit DNA repair in tumor cells and acts as a novel chemosensitizer, which are useful in methods for treating or preventing cancers.


Tyrosine family recombinases (YRs) are widely utilized in genome engineering systems because they can easily direct DNA rearrangement. Cre recombinases, one of the most commonly used types of YRs, catalyze site-specific recombination between two loxP sites without the need for high-energy cofactors, other accessory proteins or a specific DNA target sequence between the loxP sites. Previous structural, analytical ultracentrifuge and electrophoretic analyses have provided details of the reaction kinetics and mechanisms of Cre recombinase activity; whether there are reaction intermediates or side pathways involved has been left unaddressed. Using tethered particle motion (TPM), the Cre-mediated site-specific recombination process has been delineated, from beginning to end, at the single-molecule level, including the formation of abortive complexes and wayward complexes blocking inactive nucleoprotein complexes from entering the recombination process. Reversibility in the strand-cleavage/-ligation process and the formation of a thermally stable Holliday junction intermediate were observed within the Cre-mediated site-specific recombination process. Rate constants for each elementary step, which explain the overall reaction outcomes under various conditions, were determined. Taking the findings of this study together, they demonstrate the potential of single-molecule methodology as an alternative approach for exploring reaction mechanisms in detail. © 2012 The Author(s).


Kuo J.-C.,National Yang Ming University
Journal of Cellular and Molecular Medicine | Year: 2013

Focal adhesions (FAs) are complex plasma membrane-associated macromolecular assemblies that serve to physically connect the actin cytoskeleton to integrins that engage with the surrounding extracellular matrix (ECM). FAs undergo maturation wherein they grow and change composition differentially to provide traction and to transduce the signals that drive cell migration, which is crucial to various biological processes, including development, wound healing and cancer metastasis. FA-related signalling networks dynamically modulate the strength of the linkage between integrin and actin and control the organization of the actin cytoskeleton. In this review, we have summarized a number of recent investigations exploring how FA composition is affected by the mechanical forces that transduce signalling networks to modulate cellular function and drive cell migration. Understanding the fundamental mechanisms of how force governs adhesion signalling provides insights that will allow the manipulation of cell migration and help to control migration-related human diseases. © 2013 The Authors Journal of Cellular and Molecular Medicine Published by Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.


BACKGROUND: Substantial infective endocarditis (IE)-related morbidity and mortality may occur even after successful treatment. However, no previous study has explored long-term hard end points (ie, stroke, myocardial infarction, heart failure, cardiovascular death) in addition to all-cause mortality in IE survivors.METHODS AND RESULTS: A nationwide population-based cohort study was conducted among IE survivors identified with the use of the Taiwan National Health Insurance Research Database during 2000 to 2009. IE survivors were defined as those who survived after discharge from first hospitalization with a diagnosis of IE. A total of 10 116 IE survivors were identified. IE survivors were matched to control subjects without IE at a 1:1 ratio through the use of propensity scores. The primary outcomes were stroke, myocardial infarction, readmission for heart failure, and sudden cardiac death or ventricular arrhythmia. The secondary outcomes were repeat IE and all-cause mortality. Compared with the matched cohort, IE survivors had higher risks of ischemic stroke (adjusted hazard ratio [aHR], 1.59; 95% confidence interval [CI], 1.40-1.80), hemorrhagic stroke (aHR, 2.37; 95% CI, 1.90-2.96), myocardial infarction (aHR, 1.44; 95% CI, 1.17-1.79), readmission for heart failure (aHR, 2.24; 95% CI, 2.05-2.43), sudden death or ventricular arrhythmia (aHR, 1.69; 95% CI, 1.44-1.98), and all-cause death (aHR, 2.27; 95% CI, 2.14-2.40). Risk factors for repeat IE were older age, male sex, drug abuse, and valvular replacement after an initial episode of IE.CONCLUSION: Despite treatment, the risk of long-term major adverse cardiac events was substantially increased in IE survivors. © 2014 American Heart Association, Inc.


BACKGROUND—: Substantial infective endocarditis (IE)-related morbidity and mortality may occur even after successful treatment. However, no previous study has explored long-term hard endpoints (i.e., stroke, myocardial infarction, heart failure, cardiovascular death) in addition to all-cause mortality in IE survivors.METHODS AND RESULTS—: A nationwide population-based cohort study was conducted among IE survivors identified using Taiwanʼs National Health Insurance Research Database during 2000-2009. IE survivors were defined as those who survived after discharge from first hospitalization with a diagnosis of IE. A total of 10,116 IE survivors were identified. IE survivors were matched to control subjects without IE at a 1:1 ratio using propensity scores. The primary outcomes were stroke, myocardial infarction, readmission for heart failure, and sudden cardiac death or ventricular arrhythmia. The secondary outcomes were repeat IE and all-cause mortality. Compared with the matched cohort, IE survivors had higher risks of ischemic stroke (adjusted hazard ratio [aHR], 1.59; 95% confidence interval [CI], 1.40 to 1.80), hemorrhagic stroke (aHR, 2.37; 95% CI, 1.90 to 2.96), myocardial infarction (aHR, 1.44; 95% CI, 1.17 to 1.79), readmission for heart failure (aHR, 2.24; 95% CI, 2.05 to 2.43), sudden death or ventricular arrhythmia (aHR, 1.69; 95% CI, 1.44 to 1.98) and all-cause death (aHR, 2.27; 95% CI, 2.14 to 2.40). Risk factors for repeat IE were older age, male sex, drug abuser, and valvular replacement after an initial episode of IE.CONCLUSIONS—: Despite treatment, the risk of long-term major adverse cardiac events was substantially increased in IE survivors. © 2014 by the American College of Cardiology Foundation and the American Heart Association, Inc.


The present invention provides a method of obtaining a classification boundary, to limit an axial depth in a puncturing operation. The following steps of method comprises: At first, obtaining a plurality of tomographic images from the axial depth of a tissue is performed. Then, obtaining a plurality of characteristic values from the tomographic images, the characteristic values are classified by a Support Vector Machine method. A classification boundary will be obtained through a distribution of the graph for defining a specific compartment of the tissue. In addition, an automatic recognition method and system using the above mentioned method are also disclosed in the present invention.


Patent
National Yang Ming University | Date: 2015-08-13

The present invention relates to a new approach for treating a cancer or fibrosis, such as hepatocellular carcinoma, or liver fibrosis using an extract from a plant of Graptopetalum sp., Rhodiola sp., or Echeveria sp., and prepared by extracting the plant with dimethyl sulfoxide (DMSO), its fraction or the compound isolated from the extract.


Patent
National Yang Ming University | Date: 2016-01-13

The present invention provides a prism. The prism includes a lower surface, an upper surface, a first side surface and a second side surface. The first side surface and the second side surface are disposed between the upper surface and the lower surface. The first side surface and the second side surface of the prism are one-dimensional parabolic surfaces. The lower surface is used to receive light. The first side surface is used to reflect the light from the lower surface to the upper surface. The second side surface is used to reflect the light from the upper surface to the lower surface for further analysis in the process unit afterwards.


Patent
National Yang Ming University | Date: 2015-02-06

A portable quantification apparatus for assessing joint accessory movement is disclosed in the present invention. The apparatus includes a reference module, a movement module, a sliding module and a displacement sensor module. The reference module has a first probe and a first force sensor. The movement module has a second probe and a second force sensor. The sliding module is disposed between the reference module and the movement module which allows the movement module to slide alongside with the reference module. When a patient is under a test, the first probe is against one of two adjacent bones of a joint, while the second probe is against the other adjacent bone. The first force sensor and the second force sensor sense a first force and a second force applying to the reference module and the movement module respectively. The displacement sensor module measures the displacement of the movement module over the reference module.

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