National University of Science and Technology "MISIS" | Date: 2017-09-27
Field of the Invention. This invention relates to nanomedical technologies, namely to the fabrication of nanocarriers of drugs for antitumor chemotherapy. Disclosure of the Invention. The technical result of the invention consists of increasing the efficiency of antitumor chemotherapy by increasing the activity of the cell absorption of nanocontainers loaded with an antitumor drug, avoiding of the nanocontainer toxicity for cells due to the use of dispersed boron nitride nanoparticles of 50-300 nm in diameter with a well-developed outer surface. Technical result is achieved as follows. The method of boron nitride nanoparticles fabrication for antitumor drug delivery to tumor cells includes synthesis of spherical boron nitride nanoparticles of 50-300 nm in diameter with a well-developed outer surface by chemical vapor deposition using ammonia reaction gas, argon transport gas and powder mixture composed of amorphous boron and oxidizing reactants. Chemical deposition is carried out under the following conditions. 1000T1430 1.28, where T is the temperature of the powder mixture, is the ratio of the specific flows FAr/FNH3, where FAr is the specific flow of the transport gas and FNH3 is the specific flow of the reactant gas. The ultrasonic treatment of BN nanoparticles agglomeration is realized followed by saturation of nanoparticles with antitumor drug by sorption and washing in distilled water.
Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: INCO.2012-2.1 | Award Amount: 1.79M | Year: 2012
The overall strategy of BILAT-RUS 2 puts the three main issues of the Capacities work programme into practice. It will provide input for the EU-Commission on the state of EU-Russian STI cooperation; contribute to coordinate research policies and programmes of European Member States, Associated Countries and the EU-Commission; enhance information collection and dissemination as regards STI between Russia and the EU; raise awareness of researchers in Russia and the EU for cooperation potentials; monitor the existing STI cooperation praxis and facilitate the implementation of a sustainable cooperation support system; analyse the Russian innovation system and provide support for enhanced implementation of R&D results; deliver a feasibility study for a common representation of European scientific institutions in Russia. One of the major success factors is the close continuous dialogue and the coordination of activities with Russian and European authorities, addressing in particular the Ministry of Education and Science of the Russian Federation (MON), responsible Ministries/Agencies in EU Member States and the EU Commission. The individual activities and tasks that are proposed in the work packages of the project cover a wide array of activities. They include general information and awareness raising activities, the maintenance of the established web-portal with data and knowledge bases on STI issues as well as a inventory and analysis of existing cooperation instruments, the preparation of three yearly analytical reports on the state of EU-Russian STI cooperation, the publication of guidelines for better implementation of R&D results, a feasibility study for a common representation of European scientific organisations in Russia, as well as a mobility grant scheme. Also, activities include the establishment of an external quality control body and an Advisory Board.
Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: FoF.NMP.2012-7 | Award Amount: 7.86M | Year: 2012
The general objective of EFEVE project is the improvement of the new technologies to manufacturing of materials (aluminium and magnesium alloy) and processes and new technologies of production that are more energy efficient, improve manufacturing productivity, optimize raw material consumption, flexible mold changes and manufacturing capability of producing multiple components, ...etc. The development made in the EFEVE project aim at reducing the energy consumption of up to 20% compared with current systems. To reach these objectives, we will first investigate innovative new manufacturing alloy and new materials (SP3). The first one will be add nano-reinforcer to aluminium and magnesium alloy, the second technologies gives a mixing nano-reinforced and their characterization. This method also has a potential to improve the metallurgical quality and reduce the quantity of residues and low of cost of materials. The research and the developments of the project will take into account the EU policies for Eco design, therefore the following parameters will be considered, in addition to those related with the working conditions (temperature, pressure, melted material flow, etc..)).
Nemkov N.,National University of Science and Technology "MISIS"
European Physical Journal C | Year: 2017
On the space of generic conformal blocks the modular transformation of the underlying surface is realized as a linear integral transformation. We show that the analytic properties of conformal block implied by Zamolodchikov’s formula are shared by the kernel of the modular transformation and illustrate this by explicit computation in the case of the one-point toric conformal block. © 2017, The Author(s).
Tomei Diamond Co., Russian Academy of Sciences, National University of Science and Technology "MISIS" | Date: 2010-11-09
A substrate for depositing diamond by CVD, comprising a base body of hard material and a coating layer that holds diamond particles as seed crystal in a matrix and is deposited joined thereto on a surface of said base body, wherein:
Golovin I.S.,National University of Science and Technology "MISIS"
Materials and Design | Year: 2015
Frequency, amplitude, and temperature dependent effects of anelasticity in Fe-Ga and Fe-Ga-Al alloys are studied by mechanical spectroscopy techniques using forced bending and torsion subresonance vibrations (f from 0.001 to 200Hz, ε from 10-6 to 10-2, T from 0 to 600°C). The structure and the properties of the studied alloys are characterized by scanning electron microscopy and magnetic force microscopy. Main regularities of amplitude dependent damping are attributed to magnetomechanical damping, which is very sensitive to the structural state of alloys, their composition, magnetostriction, and testing method. Two maximal damping peaks at about 18% and 27%Ga correspond to similar maxima of magnetostriction against %Ga. Both temperature dependent thermally activated relaxation effects and anelastic effects due to phase transitions are discussed in terms of alloys structures. Thermally activated internal friction peaks are ascribed to different atomic mechanisms. A phase transition from bcc originated structures (A2 and D03) to an fcc ordered structure (L12) is accompanied by a transient anelastic effect typical for a shear diffusionless transition. © 2015 Elsevier Ltd.
Naumenko N.F.,National University of Science and Technology "MISIS"
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control | Year: 2014
Dispersion of Lamb waves propagating in AlN plates with a periodic Al grating on the top surface and an Al electrode on the bottom surface is investigated using the numerical technique SDA-FEM-SDA, which combines finite element modeling (FEM) analysis of the electrode region with spectral-domain analysis (SDA) of the adjacent multi-layered half-spaces. Characteristics of zero-order and higher-order Lamb waves are presented as functions of plate thickness and spectral frequency, which varies in the first Brillouin zone. The structures of typical Lamb waves are examined via visualization of the instantaneous displacement fields in the AlN plate confined between the grating and the bottom electrode. The mechanism of building hybrid modes, which arise from intermode coupling between the counter-propagating Lamb waves of different symmetry and order, is illustrated by two examples of modes propagating with wavelengths λ = 3p and λ = 4p, where p is the pitch of the grating. © 2014 IEEE.
Zhevnenko S.N.,National University of Science and Technology "MISIS"
Metallurgical and Materials Transactions A: Physical Metallurgy and Materials Science | Year: 2013
The surface energies of Cu-Co solid solutions in hydrogen atmosphere were measured. The measurements were performed on pure copper and copper alloys containing 0.45, 0.7, 1.4, 2.25, 2.50, and 2.8 at. pct Co and 4.1 at. pct Co for the temperature range 1245 K to 1349 K (972 C to 1076 C). The experiments were conducted using the zero creep method for 18 mcm foils. The modified method allowed "in situ" determining of the surface energy. It was shown that the surface energy increases as the concentration increases up to 1.4 at. pct Co and then decreases. Such extreme behavior was obtained by the direct method for the first time in a solid metallic system. © 2013 The Minerals, Metals & Materials Society and ASM International.
Prosviryakov A.S.,National University of Science and Technology "MISIS"
Journal of Alloys and Compounds | Year: 2015
Copper-based composites reinforced with 15-35 wt.% SiC were produced by mechanical alloying in a planetary mill and hot pressing. Grinded copper chips less than 5000 μm in size and 10 μm SiC particles were used as initial materials. Optical and scanning electron microscopes were used for microstructural analysis. The paper analyzes the effect of SiC content on hardness, electrical conductivity, density and CTE. The results demonstrate that an increase in milling time and SiC content (up to 25 wt.%) leads to a higher hardness of the materials due to homogenization of the microstructure and refinement of the reinforcing particles. With an increase in SiC content over 25 wt.% (48 vol.%), the hardness decreases because of an intense reduction of the microstructural homogeneity and an increase in the porosity of compact specimens. © 2015 Elsevier B.V. All rights reserved.
National University of Science and Technology "MISIS" | Date: 2012-12-06
This invention relates to metallurgy, more specifically, to wrought aluminum base alloys, and can be used for the fabrication of products with up to 350 C. working temperature range. The technical result achieved in the first and second objects of this invention is providing a new heat resistant aluminum base alloy the wrought semifinished products of which (sheets, rods, wire, die forgings products or pipes) have high strength, heat resistance and electrical conductivity. Said technical result is achieved in the first object of this invention as follows. The aluminum base alloy contains copper, manganese, zirconium, silicon, iron and chromium in the following amounts, wt. %: The alloy contains zirconium in its structure in the form of Al_(3)Zr phase nanosized particles not greater than 20 nm in size, and manganese mainly forms secondary particles of the Al_(20)Cu_(2)Mn_(3 )phase not greater than 500 nm in size in a quantity of at least 2 vol. %. Said technical result is achieved in the second object of this invention as follows. The method of fabricating wrought semifinished products from said aluminum base alloy comprises producing a melt of the alloy and fabricating a cast piece by solidifying said alloy, these operations being carried out at a temperature that is at least 50 C. above the liquidus temperature. The intermediate wrought semifinished product is obtained by deforming said cast piece at a temperature of within 350 C. in two stages with an intermediate 340-450 C. anneal. Then the intermediate wrought semifinished product is annealed at 340-450 C., and wrought semifinished product is obtained by deforming the intermediate wrought semifinished product at room temperature. Finally the wrought semifinished product is annealed at 300-400 C.