The National University of La Plata is one of the most important Argentine national universities and the biggest one situated in the city of La Plata, capital of Buenos Aires Province. It has over 90,000 regular students, 10,000 teaching staff, 16 departments and 106 available degrees.UNLP comprises the Rafael Hernández National College, the Victor Mercante Lyceum, the Bachelor of Fine Arts program, the School of Agronomy, the La Plata University Radio, the La Plata University Press and numerous academic centers for research and outreach including La Plata Museum of Natural science, the University Public Library, the Samay Huasi Retreat for Artists and Writers, the Institute of Physical Education, the Astronomical Observatory and the Santa Catalina Rural Association.The institution began operations on April 18, 1897, as the Universidad Provincial de La Plata with Dr. Dardo Rocha as its rector. In 1905, Joaquín V. González, the Minister of Justice and Public Education of the government of Manuel Quintana, decided to nationalize it. González also integrated many municipal scientific institutions into the university, and a year later he became the first President of the National University of La Plata. Today the university holds one of the most important paleontological and anthropological collections in South America. Wikipedia.
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.95M | Year: 2015
A diverse, complex, and poorly characterised community of microorganisms lies at the heart of the wine an industry worth over 220 billion globally. These microorganisms play key roles at all stages of the viniculture and vinification processes, from helping plants access nutrients from the soil, driving their health through protection against pathogens, to fermentation processes that transform the must into wine with its complex array of aromas and flavours. Given this importance, an improved understanding of the microbial community and its interplay will have significant effects on the industry. In recent years, Next Generation DNA sequencing has revolutionised many areas of biology, including microbiology, through conferring the ability to characterise microbes on the deep community scale, through both shotgun and deep amplicon sequencing approaches. To exploit this power for the benefit of the wine industry, we propose MICROWINE, a 15 ESR Marie Curie Actions European Training Network. The network is constructed as a close collaboration between industry and academic partners, around the theme of the microbial communitys role in the wine production process. Through combining microbial metagenomic sequencing with powerful computation analyses, with metadata generated using techniques such as metabolomics and geochemistry, we will study the action of microbes from the plant protection and nutrition, through to wine fermentation process, using samples collected from both Europe and beyond. We will further train the ESRs across a wide range of relevant disciplines, and maximise information transfer through multiple host and academic-industry cosupervision and secondments. In this way, we anticipate contributing to the strength and scientific progress of the wine industry through training of a cohort of leading, interdisciplinary and tightly interconnected scientists at the forefront of modern microbiological, genomic, computational and related techniques.
Plant Bioscience Ltd, National University of La Plata and Conicet | Date: 2013-08-23
The application relates to methods for increasing plant yield and transgenic plants with increased yield using a plant protease.
Conicet, National University of La Plata and Inis Biotech Llc | Date: 2014-03-25
A vaccine for the prevention of infections with Bordetella, comprising at least outer membrane vesicles (OMVs) of B. parapertussis, excipients and/or adjuvants. Bordetella may be, for example, B. pertussis or B. parapertussis. The vaccine can comprise adjuvants, for example, aluminum hydroxide and other immunogens such as tetanus toxoid, diphtheria toxoid, or combinations thereof. In another preferred embodiment, the vaccine for the prevention of infections with Bordetella comprises at least outer membrane vesicles (OMVs) of B. pertussis and the lipopolysaccharide of B. parapertussis, excipients and/or adjuvants. The vaccine can comprise between 3 to 20 g per dose of OMVs from B. pertussis and between the amount equivalent to 10^(7 )and 10^(10 )bacteria per dose of lipopolysaccharide of B. parapertussis. The adjuvant can be aluminum hydroxide and other immunogens such as tetanus toxoid, diphtheria toxoid, or combinations thereof. The Tdap vaccine exhibits cross activity.
Catala A.,National University of La Plata
Biochimie | Year: 2012
The "Fluid Mosaic Model", described by Singer and Nicolson, explain both how a cell membrane preserves a critical barrier function while it concomitantly facilitates rapid lateral diffusion of proteins and lipids within the planar membrane surface. However, the lipid components of biological plasma membranes are not regularly distributed. They are thought to contain "rafts" - nano-domains enriched in sphingolipids and cholesterol that are distinct from surrounding membranes of unsaturated phospholipids. Cholesterol and fatty acids adjust the transport and diffusion of molecular oxygen in membranes. The presence of cholesterol and saturated phospholipids decreases oxygen permeability across the membrane. Alpha-tocopherol, the main antioxidant in biological membranes, partition into domains that are enriched in polyunsaturated phospholipids increasing the concentration of the vitamin in the place where it is most required. On the basis of these observations, it is possible to assume that non-raft domains enriched in phospholipids containing PUFAs and vitamin E will be more accessible by molecular oxygen than lipid raft domains enriched in sphingolipids and cholesterol. This situation will render some nano-domains more sensitive to lipid peroxidation than others. Phospholipid oxidation products are very likely to alter the properties of biological membranes, because their polarity and shape may differ considerably from the structures of their parent molecules. Addition of a polar oxygen atom to several peroxidized fatty acids reorients the acyl chain whereby it no longer remains buried within the membrane interior, but rather projects into the aqueous environment "Lipid Whisker Model". This exceptional conformational change facilitates direct physical access of the oxidized fatty acid moiety to cell surface scavenger receptors. © 2011 Elsevier Masson SAS. All rights reserved.
Catala A.,National University of La Plata
Frontiers in Bioscience - Scholar | Year: 2011
Retina is very rich in membranes containing polyunsaturated fatty acids. Reactive oxygen species initiates chain reactions of lipid peroxidation which injure the retina, especially the membranes that play important roles in visual function. Furthermore, biomolecules such as proteins or amino lipids can be covalently modified by lipid decomposition products. In retinal membranes, peroxidation of lipids is also usually accompanied by oxidation of membrane proteins. In consequence, lipid peroxidation may alter the arrangement of proteins in bilayers and by that interfere with their physiological role on the membrane function. Here, we review several studies on the lipid peroxidation of membrane phospholipids in retina. Particular emphasis is placed on the molecular changes of very long chain polyunsaturated fatty acids associated with protein modifications during peroxidation of photoreceptor membranes. Furthermore we use liposomes to analyze peroxidation of retinal lipids. Conjugated dienes formed from oxidized PUFAs, and TBARS products derived from the breakdown of these fatty acids located in phospholipids can be analyzed during lipid peroxidation of liposomes made of retinal lipids using Fe2+ and Fe3+ as initiators.
Colinas P.A.,National University of La Plata
Current Organic Chemistry | Year: 2012
Native glycosidic bonds in carbohydrates, are sensitive to the presence of enzymes. Thus, design of small molecule mimics (glycomimetics) is an active area of research. This review will focus on the development of a new class of glycomimetics: anomeric and N-glycosyl sulfonamides. These novel compounds have been demonstrated to be enzyme inhibitors or antiproliferative agents. © 2012 Bentham Science Publishers.
Ibanez F.J.,National University of La Plata |
Zamborini F.P.,University of Louisville
Small | Year: 2012
This review describes the use of chemically modified pure and alloyed metal nanoparticles for chemiresistive sensing applications. Chemically modified metal nanoparticles consist of a pure or alloyed metallic core with some type of chemical coating. Researchers have studied the electronic properties of 1D, 2D, and 3D assemblies of chemically modified metal nanoparticles, and even single individual nanoparticles. The interaction with the analyte alters the conductivity of the sensitive material, providing a signal to measure the analyte concentration. This review focuses on chemiresistive sensing of a wide variety of gas- and liquid-phase analytes with metal nanoparticles coated with organothiols, ions, polymers, surfactants, and biomolecules. Different strategies used to incorporate chemically modified nanoparticles into chemiresistive sensing devices are reviewed, focusing on the different types of metal and alloy compositions, coatings, methods of assembly, and analytes (vapors, gases, liquids, biological materials), along with other important factors. A material that changes resistance in the presence of gas and liquid analytes is termed a chemiresistor. A chemiresistive film of various dimensions comprises organic-modified nanoparticles where electron hopping occurs when a voltage (V) is applied. The current of the film changes over time in the presence of analytes in the gas- or liquid-phase (blue dots). © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Baran E.J.,National University of La Plata
Current Medicinal Chemistry | Year: 2010
Chelation therapy occupies a central place in modern medicine and pharmacology, because continuous studies with laboratory animals and extensive clinical experience demonstrate that acute or chronic intoxications with a variety of metals can be considerable improved by administration of a suitable chelating agent. In this review the chemical characteristics, properties and uses of the most common chelating agents as well as those of some new and very promising agents of this type, are discussed. In the second part of the review the biological and biochemical impact of these agents, as well as their use for the treatment of some selected diseases and disorders, are also analyzed and discussed in detail. © 2010 Bentham Science Publishers Ltd.
Azzaroni O.,National University of La Plata
Journal of Polymer Science, Part A: Polymer Chemistry | Year: 2012
Bottom-up surface processing with well-defined polymeric structures becomes increasingly important in many current technologies. Polymer brushes, that is, assemblies of macromolecules tethered at one end to a substrate, provide an exemplary system of materials capable of achieving such a goal. While the focus in the past decades has been mostly on their synthetic aspects and the in-depth study of their interesting properties, from several years now the core area of research has already started to shift towards specific practical applications. Ample functional versatility and relative ease of preparation are special strengths of polymer brushes, lending them a strong interdisciplinary character. To this end, this work is entirely dedicated to bringing together the latest research on applications of polymer brushes in multiple research fields. The aim of this review are twofold: first, to give a critical discussion of the current status of development of application-oriented research on polymer brushes, and second, to inform the reader as to what can be done with polymer brushes in multiple research fields. It is therefore hoped that the juxtaposition of perspectives from different disciplines in one place will stimulate and contribute to the ongoing process of cross-fertilization that is driving this fascinating and emerging area of polymer science. © 2012 Wiley Periodicals, Inc.
Agency: Cordis | Branch: FP7 | Program: MC-IIFR | Phase: FP7-PEOPLE-2011-IIF | Award Amount: 15.00K | Year: 2013
The European Union is conscious about the fundamental problems arisen from the current energy system, based mainly on hydrocarbons and has a firm commitment to encourage renewable energy technologies research. Among experts in energy there is a growing trend to promote Decentralised Electrical Generation Systems (DEGS) with modular efficient non polluting generation plants. DEGS that incorporate hydrogen as an energetic vector are of particular interest. Hydrogen can be easily produced, stored and efficiently converted into electricity by means of fuel cells, adding great flexibility to DEGS. However, fuel cells based DEGS exhibit complex non linear behaviour, have inaccessible variables and withstand severe disturbances, so special controllers are required. A wide range of linear controllers have been already proposed, but the validity of the results cannot be extrapolated. The development of advanced control systems for fuel cell based DEGS that incorporate renewable energy sources is then not merely a challenging area of research, but is also a field of great interest for environmental, social, economic and strategic reasons. The key aim of this project is the development of advanced controllers capable to improve the efficiency of fuel cells\wind power based DEGS. They will be implemented and tested in the ACES labs in Barcelona. The results of this implementation will be used to assess the theoretical developments and will also provide a technology demonstrator to aid technology transfer to industry. The main objectives of the proposed project are threefold: - Scientific. Advanced controllers will be developed to improve the efficiency of DEGS - Knowledge transfer. The Visiting Professor will instruct and train the host group in new control techniques, particularly higher order sliding mode. - Strategic. The Visiting Professor will advise the host group in the new trends of renewable energies generation systems integration and control.