Mar del Plata, Argentina

National University of La Plata
Mar del Plata, Argentina

The National University of La Plata is one of the most important Argentine national universities and the biggest one situated in the city of La Plata, capital of Buenos Aires Province. It has over 90,000 regular students, 10,000 teaching staff, 16 departments and 106 available degrees.UNLP comprises the Rafael Hernández National College, the Victor Mercante Lyceum, the Bachelor of Fine Arts program, the School of Agronomy, the La Plata University Radio, the La Plata University Press and numerous academic centers for research and outreach including La Plata Museum of Natural science, the University Public Library, the Samay Huasi Retreat for Artists and Writers, the Institute of Physical Education, the Astronomical Observatory and the Santa Catalina Rural Association.The institution began operations on April 18, 1897, as the Universidad Provincial de La Plata with Dr. Dardo Rocha as its rector. In 1905, Joaquín V. González, the Minister of Justice and Public Education of the government of Manuel Quintana, decided to nationalize it. González also integrated many municipal scientific institutions into the university, and a year later he became the first President of the National University of La Plata. Today the university holds one of the most important paleontological and anthropological collections in South America. Wikipedia.

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TORONTO, ONTARIO--(Marketwired - May 11, 2017) - Lithium Energi Exploration, Inc. (TSX VENTURE:LEXI) ("LEXI" or the "Company") is pleased to announce that it has secured an exclusive right of first refusal ("ROFR") to acquire from Resource Ventures S.A. ("ReVe") over 100,000 hectares of prospective lithium brine properties in the province of Catamarca, Argentina. The ROFR gives LEXI rights to acquire approximately 42,000 hectares of lithium brine prospects located in the Salar de Antofalla and approximately 60,000 hectares in the Salar de Pipanaco. In the Antofalla salar alone, these acquisitions would increase LEXI's holdings to over 152,000 hectares and expand its total lithium brine prospects in Argentina to more than 230,000 hectares. Located less than 20 km west of FMC Corp.'s lithium operation (Argentina's largest lithium producer) in northern Catamarca Province, Antofalla hosts one of the largest basins in the region. It is over 130 km long and varies between 5 and 20 km across. On September 12, 2016, Albemarle Corp., the world's largest producer of lithium, announced its acquisition of exclusive exploration and acquisition rights to a claim block located in the center section of this salar. At that time, Albemarle stated its belief that Antofalla will be certified as the largest lithium resource in Argentina. It acquired its claim block from Bolland Minera S.A., a large, private mining firm with operations in multiple countries. Bolland has also obtained substantial claim blocks in Antofalla, establishing a major position in this prospectively valuable resource. In 2016, Roskill information Services reported that Bolland had drilled 56 boreholes over 265km2 and defined a resource of 83mt of potash (KCl) grading 6,400mg/l and 2.22mt of lithium (11.8mt LCE) grading 350mg/l. Drilled between 2008 and 2011 in the section now owned by Albemarle, Bolland's test wells were completed in conjunction with the Institute of Mineral Resources for the National University of La Plata in Buenos Aires. Well logs, permeability, hydraulic gradient, core sample chemistry, and gravimetric studies published during that period indicated substantial values for lithium and potassium continuously observed from the surface down to a depth of over 500 meters, suggesting that Antofalla is one of the deepest basins in the region. "As suggested in Bolland's tests, subsurface brines in regional salars can be quite uniform across a salar's associated basin and we expect to see similar circumstances as we drill and explore LEXI's properties in this immense Antofalla basin," stated Miles Rideout, LEXI's Director of Exploration. The ROFR claims in Pipanaco consist of over 60,000 hectares covering more than 85% of this salar, which is located approx. 50 km due west of Catamarca city. The properties are in early exploration with minimal surface samples being collected to date. This salar was drilled more than ten years ago in a program for the federal government of Argentina to identify new sources of fresh water. Based on those drilling reports, the Company believes that these Pipanaco holdings, which are located at only 700-750 meters above sea level, could represent a very favorable site for a lithium extraction facility, as well as being a potential location to create a regional lithium processing facility located less than a two-hour drive from Catamarca city. The ROFR provides LEXI with a 12-month period of exclusivity during which it intends to pursue suitable terms and conditions pursuant to which it may acquire one or both of the projects presently owned by ReVe in Argentina. If exercised, the Company's prospective lithium properties would increase from its present holdings of over 128,000 hectares to greater than 230,000 hectares in the Catamarca Province. "The future success of lithium producers will, in part, be driven by the location and value of a company's reserves, so when our Board requested we enhance LEXI's holdings by including other strategic properties acquired before the new management team joined LEXI, this ROFR was secured to emphatically affirm our dedication to growing reserve values that will strengthen the Company and benefit our shareholders," noted LEXI's CEO, Steven Howard. ReVe is controlled by Steven Howard and Omar Ortega, who are both shareholders and officers of LEXI. The properties were acquired by ReVe, and were known to LEXI's Board of Directors, prior to Mr. Howard and Mr. Ortega joining LEXI in April, 2017. Any agreement to acquire these assets would be a non-arms-length transaction subject to approvals by both the TSX Venture Exchange and LEXI's shareholders and to other conditions customary in transactions of this nature. The technical content of this news release has been reviewed and approved by Caitlin Jeffs, P. Geo., a consultant of the Company, and a qualified person as defined by National Instrument 43-101. Lithium Energi Exploration, Inc. is an exploration company specializing in the strategic acquisition, exploration and development of lithium brine assets in Argentina. The Company is headquartered in Toronto, Ontario and has offices in Dallas, Texas and Catamarca, Argentina. The common shares of the Company are listed on the TSX Venture Exchange (TSX VENTURE:LEXI). The Company recently completed the acquisition of a portfolio of projects comprising over 128,000 hectares of lithium brine concessions in the Argentina Province of Catamarca in the heart of the lithium triangle. ON BEHALF OF THE BOARD OF DIRECTORS Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release. The forward looking statements contained herein are expressly qualified in their entirety by this cautionary statement. The forward looking statements included in this news release are made as of the date of this news release and the Company does not undertake and is not obligated to publicly update such forward looking statements to reflect new information, subsequent events or otherwise unless so required by applicable securities laws.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.95M | Year: 2015

A diverse, complex, and poorly characterised community of microorganisms lies at the heart of the wine an industry worth over 220 billion globally. These microorganisms play key roles at all stages of the viniculture and vinification processes, from helping plants access nutrients from the soil, driving their health through protection against pathogens, to fermentation processes that transform the must into wine with its complex array of aromas and flavours. Given this importance, an improved understanding of the microbial community and its interplay will have significant effects on the industry. In recent years, Next Generation DNA sequencing has revolutionised many areas of biology, including microbiology, through conferring the ability to characterise microbes on the deep community scale, through both shotgun and deep amplicon sequencing approaches. To exploit this power for the benefit of the wine industry, we propose MICROWINE, a 15 ESR Marie Curie Actions European Training Network. The network is constructed as a close collaboration between industry and academic partners, around the theme of the microbial communitys role in the wine production process. Through combining microbial metagenomic sequencing with powerful computation analyses, with metadata generated using techniques such as metabolomics and geochemistry, we will study the action of microbes from the plant protection and nutrition, through to wine fermentation process, using samples collected from both Europe and beyond. We will further train the ESRs across a wide range of relevant disciplines, and maximise information transfer through multiple host and academic-industry cosupervision and secondments. In this way, we anticipate contributing to the strength and scientific progress of the wine industry through training of a cohort of leading, interdisciplinary and tightly interconnected scientists at the forefront of modern microbiological, genomic, computational and related techniques.

Colinas P.A.,National University of La Plata
Expert Opinion on Therapeutic Patents | Year: 2013

A series of novel ureido-sulfonamides was prepared by reaction of aminobenzenesulfonamide with alkyl/aryl isocyanate. These compounds are claimed for use as therapeutic agents of metastatic tumors, which are poorly responsive to classical chemotherapies and constitute a conceptually novel approach for cancer treatment. © 2013 Informa UK, Ltd.

Talevi A.,National University of La Plata
Current Pharmaceutical Design | Year: 2016

Background: In contrast to the one target-one drug paradigm, multi-target agents seem as a promising alternative to manage complex disorders and health conditions linked to drug resistance issues. In fact, many longstanding drugs are in fact unintended multi-functional therapeutics that have emerged from phenotypic screening. The last two decades, however, have witnessed the emergence of tailored multi-target agents, which according to our perspective combine the best aspects of target-based and phenotypic-based drug discovery. Methods: We discuss a number of considerations related to the design, screening and computer-aided discovery of multi-targeted drugs, along with overlooked advantages that this type of agents might have in clinical trials. A theoretic example is included to explain the reduced positive predictive value in virtual screening campaigns focused on multi-target agents. Conclusion: Multi-target agents present great therapeutic potential for the treatment of complex health conditions and the solution of drug resistance phenomena. However, they are certainly challenging for computer-aided drug discovery approaches. Merged or overlapping pharmacophores should be preferred whenever possible. It is thus suggested to perform a careful selection of the combination of pursued targets, preferring target combinations supported by co-evolution or similar biding sites. © 2016 Bentham Science Publishers.

Plant Bioscience Ltd, National University of La Plata and Conicet | Date: 2013-08-23

The application relates to methods for increasing plant yield and transgenic plants with increased yield using a plant protease.

Conicet, National University of La Plata and Inis Biotech Llc | Date: 2014-03-25

A vaccine for the prevention of infections with Bordetella, comprising at least outer membrane vesicles (OMVs) of B. parapertussis, excipients and/or adjuvants. Bordetella may be, for example, B. pertussis or B. parapertussis. The vaccine can comprise adjuvants, for example, aluminum hydroxide and other immunogens such as tetanus toxoid, diphtheria toxoid, or combinations thereof. In another preferred embodiment, the vaccine for the prevention of infections with Bordetella comprises at least outer membrane vesicles (OMVs) of B. pertussis and the lipopolysaccharide of B. parapertussis, excipients and/or adjuvants. The vaccine can comprise between 3 to 20 g per dose of OMVs from B. pertussis and between the amount equivalent to 10^(7 )and 10^(10 )bacteria per dose of lipopolysaccharide of B. parapertussis. The adjuvant can be aluminum hydroxide and other immunogens such as tetanus toxoid, diphtheria toxoid, or combinations thereof. The Tdap vaccine exhibits cross activity.

The "Fluid Mosaic Model", described by Singer and Nicolson, explain both how a cell membrane preserves a critical barrier function while it concomitantly facilitates rapid lateral diffusion of proteins and lipids within the planar membrane surface. However, the lipid components of biological plasma membranes are not regularly distributed. They are thought to contain "rafts" - nano-domains enriched in sphingolipids and cholesterol that are distinct from surrounding membranes of unsaturated phospholipids. Cholesterol and fatty acids adjust the transport and diffusion of molecular oxygen in membranes. The presence of cholesterol and saturated phospholipids decreases oxygen permeability across the membrane. Alpha-tocopherol, the main antioxidant in biological membranes, partition into domains that are enriched in polyunsaturated phospholipids increasing the concentration of the vitamin in the place where it is most required. On the basis of these observations, it is possible to assume that non-raft domains enriched in phospholipids containing PUFAs and vitamin E will be more accessible by molecular oxygen than lipid raft domains enriched in sphingolipids and cholesterol. This situation will render some nano-domains more sensitive to lipid peroxidation than others. Phospholipid oxidation products are very likely to alter the properties of biological membranes, because their polarity and shape may differ considerably from the structures of their parent molecules. Addition of a polar oxygen atom to several peroxidized fatty acids reorients the acyl chain whereby it no longer remains buried within the membrane interior, but rather projects into the aqueous environment "Lipid Whisker Model". This exceptional conformational change facilitates direct physical access of the oxidized fatty acid moiety to cell surface scavenger receptors. © 2011 Elsevier Masson SAS. All rights reserved.

Ibanez F.J.,National University of La Plata | Zamborini F.P.,University of Louisville
Small | Year: 2012

This review describes the use of chemically modified pure and alloyed metal nanoparticles for chemiresistive sensing applications. Chemically modified metal nanoparticles consist of a pure or alloyed metallic core with some type of chemical coating. Researchers have studied the electronic properties of 1D, 2D, and 3D assemblies of chemically modified metal nanoparticles, and even single individual nanoparticles. The interaction with the analyte alters the conductivity of the sensitive material, providing a signal to measure the analyte concentration. This review focuses on chemiresistive sensing of a wide variety of gas- and liquid-phase analytes with metal nanoparticles coated with organothiols, ions, polymers, surfactants, and biomolecules. Different strategies used to incorporate chemically modified nanoparticles into chemiresistive sensing devices are reviewed, focusing on the different types of metal and alloy compositions, coatings, methods of assembly, and analytes (vapors, gases, liquids, biological materials), along with other important factors. A material that changes resistance in the presence of gas and liquid analytes is termed a chemiresistor. A chemiresistive film of various dimensions comprises organic-modified nanoparticles where electron hopping occurs when a voltage (V) is applied. The current of the film changes over time in the presence of analytes in the gas- or liquid-phase (blue dots). © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Baran E.J.,National University of La Plata
Current Medicinal Chemistry | Year: 2010

Chelation therapy occupies a central place in modern medicine and pharmacology, because continuous studies with laboratory animals and extensive clinical experience demonstrate that acute or chronic intoxications with a variety of metals can be considerable improved by administration of a suitable chelating agent. In this review the chemical characteristics, properties and uses of the most common chelating agents as well as those of some new and very promising agents of this type, are discussed. In the second part of the review the biological and biochemical impact of these agents, as well as their use for the treatment of some selected diseases and disorders, are also analyzed and discussed in detail. © 2010 Bentham Science Publishers Ltd.

Azzaroni O.,National University of La Plata
Journal of Polymer Science, Part A: Polymer Chemistry | Year: 2012

Bottom-up surface processing with well-defined polymeric structures becomes increasingly important in many current technologies. Polymer brushes, that is, assemblies of macromolecules tethered at one end to a substrate, provide an exemplary system of materials capable of achieving such a goal. While the focus in the past decades has been mostly on their synthetic aspects and the in-depth study of their interesting properties, from several years now the core area of research has already started to shift towards specific practical applications. Ample functional versatility and relative ease of preparation are special strengths of polymer brushes, lending them a strong interdisciplinary character. To this end, this work is entirely dedicated to bringing together the latest research on applications of polymer brushes in multiple research fields. The aim of this review are twofold: first, to give a critical discussion of the current status of development of application-oriented research on polymer brushes, and second, to inform the reader as to what can be done with polymer brushes in multiple research fields. It is therefore hoped that the juxtaposition of perspectives from different disciplines in one place will stimulate and contribute to the ongoing process of cross-fertilization that is driving this fascinating and emerging area of polymer science. © 2012 Wiley Periodicals, Inc.

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