Maynooth, Ireland

The National University of Ireland Maynooth , known as Maynooth University since August 2014, is a university in the town of Maynooth, Ireland. It was founded by the Universities Act, 1997 as a constituent university of the National University of Ireland, but it may be considered Ireland's second oldest university, having been formed from St Patrick's College, Maynooth which was founded in 1795. Wikipedia.

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National University of Ireland, Maynooth and Massachusetts Institute of Technology | Date: 2015-02-11

Provided is a method for correcting errors in a data transmission network, comprising: transmitting a plurality of uncoded information packets across a network path; transmitting a plurality of coded packets for recovering information packets lost in transmission across said network path, the coded packets being temporally interspersed among said uncoded information packets, wherein the coded packets are encoded based on information packets transmitted prior to a previously transmitted coded packet; and determining the interspersion of the coded packets according to a packet loss rate.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: BES-13-2015 | Award Amount: 2.04M | Year: 2016

EU Personnel in Conflict Prevention and Peace Building missions come from diverse organizations and nations, yet must coordinate together in the temporary network or umbrella organization that comprises each CPPB mission. Coordination is challenging strategically and operationally. Even if the structures to coordinate together are in place, diversity in organizations (militaries, police forces, civil organizations), gender and culture (national, ethnicity, religion) make understanding of diverse personnel, and effective communication and cooperation in contexts of diversity difficult yet vital in order to achieve CPPB missions goals. Current training puts few resources into training personnel in these critical soft skills. Gaming for Peace (GAP) provides an efficient and effective means of developing and delivering a curriculum in those skills. Deriving a base curriculum from CPPB relevant soft skills and end user identified training gaps in this area, GAP designs a multiple player online role playing game which simulates scenarios from CPPB missions. The GAP project launches an iterative process of curriculum development and refinement through end users (military, police and civilian personnel) evaluating the game and embedded base curriculum by playing the game and in doing so, bringing their own experiences to the game, thus further developing the curriculum of CPPB relevant soft skills. The game can be accessed anywhere via the Internet and there is no limit on the number of personnel who can be trained. The game can be customized at low cost by different stakeholders. The GAP consortium is multidisciplinary with expertise in the social sciences, computer science, end users (including militaries and police), and SMEs in game design, curriculum development and skill standardization and harmonization, and has support from stakeholders including the ESDC, UN bodies and NATO.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: WATER-5c-2015 | Award Amount: 3.57M | Year: 2016

The WHO estimates that in 2015 in Africa ~156 million people relied on untreated sources for their drinking water. WATERSPOUTT will design, develop, pilot and field-test a range of, sustainable point-of-use solar disinfection (SODIS) technologies that will provide affordable access to safe water to remote and vulnerable communities in Africa and elsewhere. These novel large-volume water treatment SODIS technologies will be developed in collaboration and consultation with the end-users, and include: 1. HARVESTED RAINWATER SODIS SYSTEMS for domestic and community use. (South Africa, Uganda). 2. TRANSPARENT 20L SODIS JERRYCANS. (Ethiopia) 3. COMBINED 20L SODIS/CERAMIC POT FILTRATION SYSTEMS. (Malawi) These are novel technologies that will create employment and economic benefits for citizens in both the EU and resource-poor nations. WATERSPOUTT will use social science strategies to: a. Build integrated understanding of the social, political & economic context of water use & needs of specific communities. b. Examine the effect of gender relations on uptake of SODIS technologies. c. Explore the relevant governance practices and decision-making capacity at local, national and international level that impact upon the use of integrated solar technologies for point-of-use drinking water treatment. d. Determine the feasibility & challenges faced at household, community, regional and national level for the adoption of integrated solar technologies for point-of-use drinking water treatment. WATERSPOUTT will transform access to safe drinking water through integrated social sciences, education & solar technologies, thus improving health, survival, societal well-being & economic growth in African developing countries. These goals will be achieved by completing health impact studies of these technologies among end-user communities in Africa. Many of the consortium team have worked for more than 15 years on SODIS research in collaboration with African partners.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: BG-09-2016 | Award Amount: 15.49M | Year: 2016

The overall objective of INTAROS is to develop an integrated Arctic Observation System (iAOS) by extending, improving and unifying existing systems in the different regions of the Arctic. INTAROS will have a strong multidisciplinary focus, with tools for integration of data from atmosphere, ocean, cryosphere and terrestrial sciences, provided by institutions in Europe, North America and Asia. Satellite earth observation data plays an increasingly important role in such observing systems, because the amount of EO data for observing the global climate and environment grows year by year. In situ observing systems are much more limited due to logistical constraints and cost limitations. The sparseness of in situ data is therefore the largest gap in the overall observing system. INTAROS will assess strengths and weaknesses of existing observing systems and contribute with innovative solutions to fill some of the critical gaps in the in situ observing network. INTAROS will develop a platform, iAOS, to search for and access data from distributed databases. The evolution into a sustainable Arctic observing system requires coordination, mobilization and cooperation between the existing European and international infrastructures (in-situ and remote including space-based), the modeling communities and relevant stakeholder groups. INTAROS will include development of community-based observing systems, where local knowledge is merged with scientific data. An integrated Arctic Observation System will enable better-informed decisions and better-documented processes within key sectors (e.g. local communities, shipping, tourism, fisheries), in order to strengthen the societal and economic role of the Arctic region and support the EU strategy for the Arctic and related maritime and environmental policies.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EO-3-2014 | Award Amount: 6.00M | Year: 2015

There is a recognised need for establishing sound methods for the characterisation of satellite-based Earth Observation (EO) data by surface-based and sub-orbital measurement platforms - spanning Atmosphere, Ocean and Land observations and the entire radiance spectrum. Robust EO instrument characterisation is about significantly more than simply where and when a given set of EO and ground-based / sub-orbital measurements is taken. It requires, in addition, quantified uncertainty estimation for the reference measurements and an understanding of additional uncertainties that accrue through mismatches in sampling location and time and the distinct measurement footprints to enable a complete mapping of the reference measurements onto EO measurements. It also needs user tools which include statistical tools and the integrating capabilities afforded by data assimilation systems to enable users to access and work with the data in a virtual observatory setting. It is only if robust uncertainty estimates are placed on the ground-based and sub-orbital data and used in the analysis that unambiguous interpretation of EO sensor performance can occur.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: WASTE-7-2015 | Award Amount: 7.65M | Year: 2016

Continuing population and consumption growth are driving global food demand, with agricultural activity increasing to keep pace. Europe has a major agricultural waste problem, generating some 700 million tonnes of waste annually. There is an urgent need and huge opportunity to address the efficient use of agricultural wastes, co-products and by-products (AWCB) towards delivering sustainable value chains in the farming and processing sectors. As such, AgroCycle will convert low value agricultural waste into highly valuable products, achieving a 10% increase in waste recycling and valorisation by 2020. This will be achieved by developing a detailed and holistic understanding of the waste streams and piloting a key number of waste utilisation/valorisation pathways. It will bring technologies and systems from ~TRL4 to ~TRL7 within the 3 years of the project. A post-project commercialisation plan will bring commercially promising technologies/systems to TRL8 and TRL9, ensuring AgroCycle will have an enduring impact by achieving sustainable use of AWCB both inside and outside the agricultural sector, leading to the realisation of a Circular Economy. AgroCycle addresses wastes from several agricultural sectors: wine, olive oil, horticulture, fruit, grassland, swine, dairy and poultry. The AgroCycle consortium is a large (25) multi-national group (including China) comprising the necessary and relevant multi-actors (i.e. researchers; companies in the technical, manufacturing, advisory, retail sectors (Large and SMEs); lead users; end users; and trade/producer associations) for achieving the projects ambitions goals. Farmings unique regional (rural) location means that AgroCycle will help reduce the EUs Innovation Divide and address the Regional Smart Specialisation Strategies for each partner country: impact will be Regional with National and International dimensions. The presence of three partners from China ensures international synergies and a global impact.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-02-2015 | Award Amount: 6.00M | Year: 2015

The overall objective of this project is to identify novel drug candidates capable of slowing down the progression of neurodegeneration in the subset of Parkinsons disease (PD) patients with overt mitochondrial dysfunction. Multi-modal phenotypic characterisation of cohorts of monogenic PD patients with overt mitochondrial dysfunction will be used as an anchor for the discovery of two extreme cohorts of idiopathic PD patients: with and without detectable mitochondrial dysfunction. A suite of personalised in vitro, in vivo, and in silico models will be generated using induced pluripotent stem cells (iPSCs) from selected subjects and controls. An industrial quality 3D microfluidic cell culture product, specifically designed for the culture of iPSC-derived dopaminergic neurons, will be developed for use in a morphological and bioanalytical screen for lead compounds reduce mitochondrial dysfunction. By monitoring motor behaviour and in situ striatal neurochemistry at high temporal resolution, the in vivo response to lead compounds will be characterised in humanised mouse models with striatally transplants of iPSC-derived dopaminergic neurons derived from PD patients. Personalised computational models of dopaminergic neuronal metabolism and mitochondrial morphology will be developed. These in silico models will be used to accelerate drug development by prioritising pathways for metabolomic assay optimisation, stratifying idiopathic PD patients by degree of mitochondrial dysfunction, predicting new new targets to reduce mitochondrial dysfunction and mechanistic interpretation in vitro and in vivo experimental results. SysMedPD unites a highly experienced multidisciplinary consortium in an ambitious project to develop and apply a systems biomedicine approach to preclinically identify candidate neuroprotectants, for the estimated 1-2 million people worldwide who suffer from PD with mitochondrial dysfunction.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-35-2016 | Award Amount: 265.22K | Year: 2017

This project responds to the ICT-35-2016 Enabling responsible ICT-related research and innovation, topic B, and will reflect and challenge the way ICT-related research and innovation is currently approached. The computerization of society in the late 1970s has now reached a point where the global economy works through an algorithmic networked environment. This situation is addressed in this research as an algorithmic condition. Any form of ICT operates within this condition. The question is, what are the ethical codes and guidelines that guide research within this condition? The Ethics of Coding prepares research that will provide an indexical report on the conceptual and thematic issues of ICT- related research and innovation, which will suggest what an ethics for ICT related issues could be, and how that might be implemented in relation to actualized and possible ICT projects. In addition, the research addresses the extent to which the coding of the social, ethical, and pedagogic, is always already invested in the maintenance of power relations that control the economic conditions for knowledge (which regulate the global markets) with what Wendy Chun (2011) describes as a code logos. Working with the Philosopher of the human condition of the twentieth century; Hannah Arendt (1958; 1978), an inter-disciplinary think-tank research team brings Arendtian ethical philosophy into dialogue with SSH experts from a number of disciplinary fields, including thinkers of technologies and their effects on societies, philosophers of mathematics, gender and humanities experts, educational philosophy specialists, digital media thinkers, to produce a report that reflects the expression of the human algorithmic condition. The project is committed to engaging with a broad range of stakeholders to substantiate its approach and the resources requested include a substantial budget to facilitate the participation of external experts in the EoC colloquia and the final project event.

English K.,National University of Ireland, Maynooth
Immunology and Cell Biology | Year: 2013

Multipotent mesenchymal stromal cells (MSCs) have generated considerable interest in the fields of regenerative medicine, cell therapy and immune modulation. Over the past 5 years, the initial observations that MSCs could enhance regeneration and modulate immune responses have been significantly advanced and we now have a clearer picture of the effects that MSCs have on the immune system particularly in the context of inflammatory-mediated disorders. A number of mechanisms of action have been reported in MSC immunomodulation, which encompass the secretion of soluble factors, induction of anergy, apoptosis, regulatory T cells and tolerogenic dendritic cells. It is clear that MSCs modulate both innate and adaptive responses and evidence is now emerging that the local microenvironment is key in the activation or licensing of MSCs to become immunosuppressive. More recently, studies have suggested that MSCs have the capacity to sense their environment and have a role in pathogen clearance in conjunction with the resolution of insult or injury. This review focuses on the mechanisms of MSC immunomodulation discussing the multistep process of MSC localisation at sites of inflammation, the cross talk between MSCs and the local microenvironment as well as the subsequent mechanisms of action used to resolve inflammation. © 2013 Australasian Society for Immunology Inc. All rights reserved.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-EID | Phase: MSCA-ITN-2015-EID | Award Amount: 804.64K | Year: 2016

This initiative proposes an innovative training environment for 3 ESRs in a supportive environment provided by an award-winning progressive wave energy company (Aquamarine Power Ltd) and a research centre at the forefront of innovation in wave energy device optimisation and control (the Centre for Ocean Energy Research at NUIM). The ESRs will be recruited by COER and will be seconded for 50% of their time to APL. There is a clear need for a training programme that integrates academic and industrial contributions. The proposed programme integrates formal and informal training activities with a rich set of industry-academic research projects, supported by significant secondment to the industrial partner and experience with real-world tank and ocean testing, wave-energy device deployment and implementation of new research results in state-of-the-art wave energy technology. The ESRs will be enrolled in a Structured PhD programme at NUIM, and will benefit from a series of structured training models. The training programme is complemented by a set of network-wide training activities. The research programme is composed of 3 closely-knit projects in the research area of wave energy and ocean energy, which allow the ESRs to have significant interaction, yet providing each ESR with an independent set of objectives and the opportunity to play a significant role in the rapidly developing area of wave energy conversion. With a clear global requirement to provide new energy sources, this programme aims to contribute to both the rapid commercialisation of a viable and economic wave energy technology, while also providing a pipeline of well-trained engineers with research, technical and commercial skills which are badly needed by this rapidly-expanding industrial sector.

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