The National University of Ireland Maynooth , known as Maynooth University since August 2014, is a university in the town of Maynooth, Ireland. It was founded by the Universities Act, 1997 as a constituent university of the National University of Ireland, but it may be considered Ireland's second oldest university, having been formed from St Patrick's College, Maynooth which was founded in 1795. Wikipedia.
English K.,National University of Ireland, Maynooth
Immunology and Cell Biology | Year: 2013
Multipotent mesenchymal stromal cells (MSCs) have generated considerable interest in the fields of regenerative medicine, cell therapy and immune modulation. Over the past 5 years, the initial observations that MSCs could enhance regeneration and modulate immune responses have been significantly advanced and we now have a clearer picture of the effects that MSCs have on the immune system particularly in the context of inflammatory-mediated disorders. A number of mechanisms of action have been reported in MSC immunomodulation, which encompass the secretion of soluble factors, induction of anergy, apoptosis, regulatory T cells and tolerogenic dendritic cells. It is clear that MSCs modulate both innate and adaptive responses and evidence is now emerging that the local microenvironment is key in the activation or licensing of MSCs to become immunosuppressive. More recently, studies have suggested that MSCs have the capacity to sense their environment and have a role in pathogen clearance in conjunction with the resolution of insult or injury. This review focuses on the mechanisms of MSC immunomodulation discussing the multistep process of MSC localisation at sites of inflammation, the cross talk between MSCs and the local microenvironment as well as the subsequent mechanisms of action used to resolve inflammation. © 2013 Australasian Society for Immunology Inc. All rights reserved. Source
National University of Ireland, Maynooth and Massachusetts Institute of Technology | Date: 2014-04-22
National University of Ireland, Maynooth | Date: 2013-08-28
An apparatus and method for use in treating tinnitus, employs a sound processing unit, a tactile unit, and an interface therebetween. The tactile unit comprises an array of stimulators each of which can be independently actuated to apply a tactile stimulus to a subject, and an input for receiving a plurality of actuation signals from the interface and directing individual actuation signals to individual stimulators. The sound processing unit receives an audio signal at an input, analyses the signal with a digital signal processor to generate the actuation signals which are representative of the audio signal, and provides the plurality of actuation signals to the interface. In a preferred embodiment the digital signal processor divides the audio signal into a series of frames in the time domain, performs a transform on each frame to generate a set of coefficients representing said frame, and maps the set of coefficients to a set of actuation signals to be applied to the array.
National University of Ireland, Maynooth | Date: 2012-05-16
The present invention relates to a method for detecting infections caused by or associated with siderophore-secreting microorganisms and kits and components used therein for carrying out the method. In one aspect the invention relates to a method for detecting siderophores and/or detecting infections caused by or associated with siderophore-secreting microorganisms in a biological sample of a subject, the method comprising providing a solid support having either bound siderophore or a conjugate thereof, or bound anti-siderophore antibody; reacting the bound siderophore or a conjugate thereof, with an anti-siderophore antibody, and a biological sample of a subject; or reacting the bound anti-siderophore antibody with a siderophore or conjugate thereof, and a biological sample of a subject; and detecting and/or quantifying the presence of the siderophore in the biological sample.
National University of Ireland, Maynooth | Date: 2012-08-31
A synchronisation system for correlating positioning data and video data comprises a synchronisation unit which is arranged to: emit an identifier capable of being imaged by a video camera; store the identifier correlated in time with a trail of positioning data corresponding to sequential locations of the synchronisation unit, and communicate the positioning data and correlated identifier to a processing computer. A processing module is operable to nm on a processing computer and is arranged to analyse a sequence of video data to locate the imaged identifier and to determine a time within the video data at which the identifier is located.