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Mendoza, Argentina

The National University of Cuyo is the largest center of higher education in the province of Mendoza, Argentina.As of 2005, the university had 12 academic schools in the city of Mendoza and a delegation in the city of San Rafael , in addition to the Balseiro Institute, which is the most developed institute of Physics research in Argentina, located in the city of San Carlos de Bariloche . It includes the University Technological Institute which offers technical education in four other cities in Mendoza province. Moreover, UNCuyo is also devoted to improving education due to having 7 other buildings working as High Schools: C.U.C. Escuela de Comercio Martín Zapata Liceo Agrícola Escuela del Magisterio Colegio de Gral. Alvear. D.A.D Escuela Carmen Vera Arenas Wikipedia.

Tomes C.N.,National University of Cuyo
Biochemical Journal

Exocytosis is a highly regulated process that consists of multiple functionally, kinetically and/or morphologically definable stages such as recruitment, targeting, tethering and docking of secretory vesicles with the plasma membrane, priming of the fusion machinery and calcium-triggered membrane fusion. After fusion, the membrane around the secretory vesicle is incorporated into the plasma membrane and the granule releases its contents. The proteins involved in these processes belong to several highly conserved families: Rab GTPases, SNAREs (soluble NSF-attachment protein receptors), α-SNAP (α-NSF attachment protein), NSF (N-ethylmaleimide-sensitive factor), Munc13 and -18, complexins and synaptotagmins. In the present article, the molecules of exocytosis are reviewed, using human sperm as a model system. Sperm exocytosis is driven by isoforms of the same proteinaceous fusion machinery mentioned above, with their functions orchestrated in a hierarchically organized and unidirectional signalling cascade. In addition to the universal exocytosis regulator calcium, this cascade includes other second messengers such as diacylglycerol, inositol 1,4,5-trisphosphate and cAMP, as well as the enzymes that synthesize them and their target proteins. Of special interest is the cAMP-binding protein Epac (exchange protein directly activated by cAMP) due in part to its enzymatic activity towards Rap. The activation of Epac and Rap leads to a highly localized calcium signal which, together with assembly of the SNARE complex, governs the final stages of exocytosis. The source of this releasable calcium is the secretory granule itself. © The Authors Journal compilation © 2015 Biochemical Society. Source

Sanchez-Puerta M.V.,National University of Cuyo
Acta Societatis Botanicorum Poloniae

This review focuses on plant-to-plant horizontal gene transfer (HGT) involving the three DNA-containing cellular compartments. It highlights the great incidence of HGT in the mitochondrial genome (mtDNA) of angiosperms, the increasing number of examples in plant nuclear genomes, and the lack of any convincing evidence for HGT in the well-studied plastid genome of land plants. Most of the foreign mitochondrial genes are non-functional, generally found as pseudogenes in the recipient plant mtDNA that maintains its functional native genes. The few exceptions involve chimeric HGT, in which foreign and native copies recombine leading to a functional and single copy of the gene. Maintenance of foreign genes in plant mitochondria is probably the result of genetic drift, but a possible evolutionary advantage may be conferred through the generation of genetic diversity by gene conversion between native and foreign copies. Conversely, a few cases of nuclear HGT in plants involve functional transfers of novel genes that resulted in adaptive evolution. Direct cell-to-cell contact between plants (e. g. host-parasite relationships or natural grafting) facilitate the exchange of genetic material, in which HGT has been reported for both nuclear and mitochondrial genomes, and in the form of genomic DNA, instead of RNA. A thorough review of the literature indicates that HGT in mitochondrial and nuclear genomes of angiosperms is much more frequent than previously expected and that the evolutionary impact and mechanisms underlying plant-to-plant HGT remain to be uncovered. © The Author(s) 2014. Source

The transport properties of ultra-thin SrTiO(3) (STO) layers grown over YBa(2)Cu(3)O(7) electrodes were studied by conductive atomic force microscopy at the nano-scale. A very good control of the barrier thickness was achieved during the deposition process. A phenomenological approach was used to obtain critical parameters regarding the structural and electrical properties of the system. The STO layers present an energy barrier of 0.9 eV and an attenuation length of 0.23 nm, indicating very good insulating properties for the development of high-quality Josephson junctions. Source

Ambrosini D.,National University of Cuyo
Engineering Structures

Regularly, new theories and approaches about thin walled beams are presented in the literature and different comparisons are performed between them. However, in most cases, it is notable the lack of experimental data, particularly about nonsymmetrical thin walled beams, which are essential to compare the results in order to obtain reliable conclusions about the accuracy and applicability of these theories. In this paper, an experimental study about natural frequencies of doubly unsymmetrical thin walled and open cross-section beams is presented. Then, the main objective of this paper is to provide experimental data that can be used for checking the accuracy and reliability of different theories and approaches.Moreover, a theoretical-numerical model developed by the author, which is based on Vlasov's theory of thin walled beams, is applied to the actual tested beams. The results obtained with this theory are compared with the experimental ones and with those obtained with a FEM code. © 2010 Elsevier Ltd. Source

Brugnoli De Pagano O.M.,National University of Cuyo | Pagano G.L.,Centrovision Mendoza Eye Clinic

Purpose: To demonstrate the effectiveness of refractive surgery with an excimer laser to correct hyperopia and convergent strabismus caused by compensatory accommodation of refractive error. Design: Prospective, interventional, noncomparative case series. Participants: Forty-six eyes of 23 patients with hyperopia and fully or partially refractive accommodative esotropia. Methods: Patients were treated with an excimer laser and the LASIK technique between 2000 and 2010. Main Outcome Measures: Preoperative and postoperative refractive spherical equivalent and ocular alignment. Results: Mean age±standard deviation [SD] was 25±12.6 years. Mean hyperopia±SD was 3.67±1.28 diopters (D) before surgery and 0.21±0.59 D after surgery (P<0.001). The mean angle of deviation without correction was 21.0 prism diopters (Δ) before surgery and 3.7 Δ after surgery (P<0.001). Conclusions: Refractive surgery with excimer laser is a promising option for the treatment of refractive accommodative esotropia. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2012 American Academy of Ophthalmology. Source

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