National University of Co rdoba

Argentina

National University of Co rdoba

Argentina

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Baez S.,University of Buenos Aires | Baez S.,Diego Portales University | Baez S.,CONICET | Baez S.,Pontifical Catholic University of Argentina | And 21 more authors.
Frontiers in Aging Neuroscience | Year: 2014

Loss of empathy is an early central symptom and diagnostic criterion of the behavioral variant frontotemporal dementia (bvFTD). Although changes in empathy are evident and strongly affect the social functioning of bvFTD patients, few studies have directly investigated this issue by means of experimental paradigms. The current study assessed multiple components of empathy (affective, cognitive and moral) in bvFTD patients. We also explored whether the loss of empathy constitutes a primary deficit of bvFTD or whether it is explained by impairments in executive functions (EF) or other social cognition domains. Thirty-seven bvFTD patients with early/mild stages of the disease and 30 healthy control participants were assessed with a task that involves the perception of intentional and accidental harm. Participants were also evaluated on emotion recognition, theory of mind (ToM), social norms knowledge and several EF domains. BvFTD patients presented deficits in affective, cognitive and moral aspects of empathy. However, empathic concern was the only aspect primarily affected in bvFTD that was neither related nor explained by deficits in EF or other social cognition domains. Deficits in the cognitive and moral aspects of empathy seem to depend on EF, emotion recognition and ToM. Our findings highlight the importance of using tasks depicting real-life social scenarios because of their greater sensitivity in the assessment of bvFTD. Moreover, our results contribute to the understanding of primary and intrinsic empathy deficits of bvFTD and have important theoretical and clinical implications.


Almeida J.,University of Sao Paulo | Quadrana L.,Instituto Nacional de Tecnologia Agropecuaria | Asis R.,National University of Co Rdoba | Setta N.,University of Sao Paulo | And 7 more authors.
Journal of Experimental Botany | Year: 2011

Vegetables are critical for human health as they are a source of multiple vitamins including vitamin E (VTE). In plants, the synthesis of VTE compounds, tocopherol and tocotrienol, derives from precursors of the shikimate and methylerythritol phosphate pathways. Quantitative trait loci (QTL) for α-tocopherol content in ripe fruit have previously been determined in an Solanum pennellii tomato introgression line population. In this work, variations of tocopherol isoforms (α, β, γ, and δ) in ripe fruits of these lines were studied. In parallel all tomato genes structurally associated with VTE biosynthesis were identified and mapped. Previously identified VTE QTL on chromosomes 6 and 9 were confirmed whilst novel ones were identified on chromosomes 7 and 8. Integrated analysis at the metabolic, genetic and genomic levels allowed us to propose 16 candidate loci putatively affecting tocopherol content in tomato. A comparative analysis revealed polymorphisms at nucleotide and amino acid levels between Solanum lycopersicum and S. pennellii candidate alleles. Moreover, evolutionary analyses showed the presence of codons evolving under both neutral and positive selection, which may explain the phenotypic differences between species. These data represent an important step in understanding the genetic determinants of VTE natural variation in tomato fruit and as such in the ability to improve the content of this important nutriceutical. © 2011 The Author(s).


Paez J.I.,National University of Co Rdoba | Cappelletti A.L.,National University of Co Rdoba | Baruzzi A.M.,National Autonomous University of Mexico | Brunetti V.,National Autonomous University of Mexico | Strumia M.C.,National University of Co Rdoba
Macromolecular Symposia | Year: 2010

The spontaneous adsorption of the dendron 3,5-Bis (3,5-dinitrobenzoylamino) benzoic acid (D-NO2) onto gold and carbon electrodes produced conductive surfaces with electroactive chemical functions. A comparative electrochemical behavior of both electrodes after dendron immobilization led us to conclude that the self-assembly of D-NO2 on carbon is faster and stronger. Considering this advantage, the surface of magnetic maghemite nanoparticles (MNPs) was modified using D-NO2. Firstly, MNPs were modified with APS as silane coupling agent and afterwards, D-NO2 was covalently attached to the surface, achieving nitro-functionalized MNPs. Subsequently, the immobilization of these modified MNPs onto glassy carbon surfaces was explored to generate a novel platform promising for biosensors development. Copyright © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.


Grau H.R.,National University of Tucuman | Torres R.,National University of Co rdoba | Gasparri N.I.,National University of Tucuman | Blendinger P.G.,National University of Tucuman | And 2 more authors.
Journal of Arid Environments | Year: 2014

In most tropical and subtropical biomes, conservation strategies are mainly focused on the preservation of forests. However, neotropical dry forest and savanna ecoregions include open habitats that may deserve conservation attention. We analyzed the historical patterns and potential distribution of natural grasslands, as well as their biodiversity in the northern Argentina dry Chaco, which is one of the largest and yet most rapidly transforming neotropical ecoregions. Paleocological literature, historical records, and bioclimatic modeling support the hypothesis that Chaco grasslands distribution was more extended in the past, and has been historically reduced by woody encroachment resulting from environmental changes occurred in the past century. Recent research shows that natural grasslands host distinctive components of the Chaco biodiversity, and a significant proportion of the vertebrate species have a negative association with woody biomass. Ongoing land use trends continue to threaten native grasslands both in unprotected sectors (where they are converted into agriculture and planted pastures) and inside protected areas (were fire suppression is favoring woody encroachment). Current conservation policies (Protected Areas, Argentine forest law, REDD+) neglect the importance of native grasslands for biodiversity conservation. Such forest-centered initiatives should be revised to specifically include native grasslands and their biodiversity into land use strategies that adequately balance agriculture and livestock production with biodiversity conservation. © 2014 Elsevier Ltd.


Diaz M.C.,University of Texas at Brownsville | Beroiz M.,University of Texas at Brownsville | Beroiz M.,University of Texas at San Antonio | Penuela T.,University of Texas at Brownsville | And 32 more authors.
Astrophysical Journal Letters | Year: 2016

We present the results of the optical follow-up conducted by the TOROS collaboration of the first gravitational-wave event GW150914. We conducted unfiltered CCD observations (0.35-1 μm) with the 1.5 m telescope at Bosque Alegre starting ∼2.5 days after the alarm. Given our limited field of view (∼100 arcmin2), we targeted 14 nearby galaxies that were observable from the site and were located within the area of higher localization probability. We analyzed the observations using two independent implementations of difference-imaging algorithms, followed by a Random-Forest-based algorithm to discriminate between real and bogus transients. We did not find any bona fide transient event in the surveyed area down to a 5σ limiting magnitude of r = 21.7 mag (AB). Our result is consistent with the LIGO detection of a binary black hole merger, for which no electromagnetic counterparts are expected, and with the expected rates of other astrophysical transients. © 2016. The American Astronomical Society. All rights reserved.

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