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Evseev A.K.,Mendeleev University of Chemical Technology | Levina O.A.,Sklifosovsky Research Institute of Emergency Medicine | Petrikov S.S.,Sklifosovsky Research Institute of Emergency Medicine | Pinchuk A.V.,Sklifosovsky Research Institute of Emergency Medicine | And 6 more authors.
Biomedical Engineering | Year: 2016

A device for determination of the redox potential of blood plasma and serum was developed. The redox potential is determined by electrochemical measurements of the Pt electrode potential in the tested medium. Measurements are performed in an open circuit. Sixty-three healthy volunteers and 86 patients, with head injury and trans-planted kidneys, as well as resuscitated patients with acute severe injuries, were tested. The obtained results formed a basis for development of diagnostic and prognostic criteria for treatment of such patients. © 2016 Springer Science+Business Media New York Source


Lanina S.Y.,National Scientific Center for Toxicological and Biological Safety of Medical Products | Suslova V.J.,National Scientific Center for Toxicological and Biological Safety of Medical Products | Benyaev N.E.,National Scientific Center for Toxicological and Biological Safety of Medical Products
Biomedical Engineering | Year: 2012

Toxicological and biological safety of medical devices should be tested at all stages of their production. The results of the tests can be used to improve the technology of production on the basis of modern methods of physicochemical analysis. © 2012 Springer Science+Business Media, Inc. Source


Lanina S.Y.,National Scientific Center for Toxicological and Biological Safety of Medical Products | Maksimkin A.V.,National University of Science and Technology "MISIS" | Kaminskaya N.M.,National Scientific Center for Toxicological and Biological Safety of Medical Products | Kaloshkin S.D.,National University of Science and Technology "MISIS" | And 5 more authors.
Biomedical Engineering | Year: 2012

The acetabular component for an endoprosthesis of the hip and knee joints was developed based on hydroxyapatite and ultrahigh molecular weight polyethylene. The results of the physicomechanical and tribological tests of the materials allowed the composition of the material to be optimized. Toxicological tests revealed biocompatibility of such materials. Neither toxic nor mutagenic effect was observed. Thus, the prosthesis composed of 50 mass % filler can be recommended. © 2012 Springer Science+Business Media, Inc. Source


Lanina S.Y.,National Scientific Center for Toxicological and Biological Safety of Medical Products | Kaminskaya N.M.,National Scientific Center for Toxicological and Biological Safety of Medical Products | Benyaev N.E.,National Scientific Center for Toxicological and Biological Safety of Medical Products | Suslova V.J.,National Scientific Center for Toxicological and Biological Safety of Medical Products | Grigorevskaya M.S.,National Scientific Center for Toxicological and Biological Safety of Medical Products
Biomedical Engineering | Year: 2013

Chemical compounds with possible danger of migration from matrix polymers (ultrahigh molecular weight polyethylene and polysulfone) and inorganic fillers (boron carbide and tungsten) to tissues of the human body were identified and their concentration was determined. The examined materials were found to satisfy the sanitary and chemical requirements because none of the monitored parameters was above the safe limit. The results of tests of acute toxicity and irritating and sensitization effects under conditions of a subacute toxicological experiment, as well as results obtained by rapid methods (hemolytic efficiency, cytotoxicity), demonstrated that the examined materials had no adverse effect on experimental animals and can be recommended for use in medical practice. © 2013 Springer Science+Business Media New York. Source

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