National Science Research Council

Buenos Aires, Argentina

National Science Research Council

Buenos Aires, Argentina
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Erol M.M.,Technical University of Istanbul | Mourino V.,University of Buenos Aires | Mourino V.,National Science Research Council | Mourino V.,Imperial College London | And 6 more authors.
Acta Biomaterialia | Year: 2012

The aim of this study was to synthesize and characterize new boron-containing bioactive glass-based scaffolds coated with alginate cross-linked with copper ions. A recently developed bioactive glass powder with nominal composition (wt.%) 65 SiO 2, 15 CaO, 18.4 Na 2O, 0.1 MgO and 1.5 B 2O 3 was fabricated as porous scaffolds by the foam replica method. Scaffolds were alginate coated by dipping them in alginate solution. Scanning electron microscopy investigations indicated that the alginate effectively attached on the surface of the three-dimensional scaffolds leading to a homogeneous coating. It was confirmed that the scaffold structure remained amorphous after the sintering process and that the alginate coating improved the scaffold bioactivity and mechanical properties. Copper release studies showed that the alginate-coated scaffolds allowed controlled release of copper ions. The novel copper-releasing composite scaffolds represent promising candidates for bone regeneration. © 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.


Moretton M.A.,University of Buenos Aires | Moretton M.A.,National Science Research Council | Hocht C.,University of Buenos Aires | Taira C.,National Science Research Council | And 4 more authors.
Nanomedicine | Year: 2014

Background: Coadministration of rifampicin (RIF)/isoniazid (INH) is clinically recommended to improve the treatment of tuberculosis. Under gastric conditions, RIF undergoes fast hydrolysis (a pathway hastened by INH) and oral bioavailability loss.Aim: We aimed to assess the chemical stabilization and the oral pharmacokinetics of RIF nanoencapsulated within poly(-caprolactone)-b-PEG-b-poly(-caprolactone) 'flower-like' polymeric micelles.Materials and methods: The chemical stability of RIF was evaluated in vitro under acid conditions with and without INH, and the oral pharmacokinetics of RIF-loaded micelles in rats was compared with those of a suspension coded by the US Pharmacopeia.Results: Nanoencapsulation decreased the degradation rate of RIF with respect to the free drug. Moreover, in vivo data showed a statistically significant increase of RIF oral bioavailability (up to 3.3-times) with respect to the free drug in the presence of INH.Conclusion: Overall results highlight the potential of this nanotechnology platform to develop an extemporaneous liquid RIF/INH fixed-dose combination suitable for pediatric administration. Original submitted 6 April 2013; Revised submitted 7 August 201. © 2014 Future Medicine Ltd.

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