National School of Engineering in Agricultural and Food Industries
Nantes, France
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French National Institute for Agricultural Research, National School of Engineering in Agricultural and Food Industries | Date: 2013-06-12

The invention relates to a method for isolating muscle-derived stem cells that can be used in cell therapy, said method comprising the steps of (i) dissociating cells from at least one muscle sample, (ii) plating the cells obtained at the end of step (i) on a non-coated cell container, (iii) isolating the cells present in the supernatant of the non-coated cell container obtained at the end of step (ii), (iv) plating the cells obtained at the end of step (iii) on a coated cell container, (v) isolating the cells present in the supernatant of the coated cell container obtained at the end of step (iv), (vi) repeating, or not, the steps (iii) and (iv) at least one or two times, (vii) plating and culturing the cells isolated from the supernatant of the coated cell container obtained at the end of step (vi) until said cells have reached a confluence level of at least 50%, (viii) isolating, at the end of step (vii), the stem cells which can be used in cell therapy, wherein after expansion (a) at least 95% of said cells express CD44, CD73, (b) at least 95% of said cells express CD29, (c) at least 70% of said cells express CD90, and (d) said cells do not express CD4, CD8, CD34, CD45, CD31, CD1 17, CD144 and CD133. The invention also relates to said isolated stem cells and pharmaceutical compositions containing them.

Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-2013-1 | Award Amount: 1.56M | Year: 2013

DeTECH21 will provide through SME led and directed research new forensic testing services based on metabolomic profiling which will identify the misuse of prohibited and licensed chemicals in bovine and equine animals. The new services which the SME partners will obtain from the project will offer an innovative approach to drug analysis based on the monitoring of biological responses to drug use in animals rather than on the direct detection of compounds which forms the basis of current testing. The administration of both legal and illegal drugs to animals destined for food production and performance sport competition continues to be an enormous challenge. Current testing typically analyses individual samples for a single specific drug and thus is inefficient and costly. These limitations have become evident through sport anti-doping enforcement where similar testing has proved ineffectual with individuals proven to have continually evaded detection despite sustained testing. These challenges have been identified by SME partners as challenges to their long-term business sustainability. DeTECH21 aims to deliver new services to increase SME competiveness, service cost-effectiveness and market reach. This will be achieved through the use of the skills of RTD partners in innovative sample profiling techniques and the skills of SME partners in the commercial provision of analytical services. The uniqueness and innovation of the DeTECH21 project will lie in the construction of metabolomic databases which can be used to identify animals which have been exposed to exogenous substances and assist in the identification of administered compounds. This 2 year project brings into collaboration key partners from across Europe who have come together with the joint objective of delivering what will be the first commercially available forensic test service based on metabolomic analysis applicable to food safety and performance animal applications.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 3.91M | Year: 2011

Approximately 80% of all products are or were a particle at some point in their processing lifetime. Particle and colloid technology has been described as the Growth Engine of Tomorrow with the market projected to grow from $2T to $10Tr over the next decade. Alongside with this challenge, the number of researchers active in powder technology is limited and only a few universities, public and private institutes are educating specialists in this field. PowTech ITN aims to integrate inter-sectoral and multidisciplinary research in particle and powder technology into the training of 15 highly skilled young researchers, to strengthen the competitiveness of food and pharmaceutical industry and to strengthen the European Research Area. The PowTech ITN has 20 partners (9 industry) and comprises a focused research programme and a graduate school. The Focused Research programme will use an engineering design approach applied to powder processing. The understanding and modelling of powder structure from a molecular to a macro disperse scale will be used to understand how powder properties/functionality are formed or modified during processing. This knowledge will be used to select the appropriate process for production of the structure of interest. The long-term aim is to develop innovative products and to provide tools allowing minimal pilot plant trials. The PowTech Graduate School is aligned with the research objectives of the project covering relevant S&T and personal skills courses but also an intensive and continuous training in collaboration with industry. In addition to the industrial secondments, the ESRs will have industrial training in different industries. An industrial mentor will be appointed to guide their Career development plan. The ESR will also be trained in Research Methodology through preparing a research plan for their work, and later in their project by developing a research plan, supervising a MSc student, and writing a Grant application.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2011.2.3-05 | Award Amount: 3.96M | Year: 2012

More than 60% of all reported diseases in modern industrial countries are said to have their origin from malnutrition (low vitamin intake, high caloric food (fat and sugar)). As an important cause of this the high consumption of fat (saturated and trans-fatty acids, salt (sodium) and sugar (mono- and disaccharides) has been identified. With the change of society, the consumers pattern towards food consumption has and is changing dramatically. While less and less people prepare their meal at home, the increase of TV cooking shows demonstrates the opposite (European paradox). The trend towards processed and convenience food is a challenge for the food industry and those products have to be of high quality and safety at low price. Fat (saturated and trans-fatty acids), salt and sugar fulfil important functions in food manufacturing as well as in the human metabolism. But meanwhile in the industrial countries their excessive consumption can lead to health problems as stated earlier. Saltiness and sweetness perception are strong markers of the sensorial attributes of food. In the past years there have been many attempts made both by industry and by science to overcome the problem with only limited or no success. All approaches known where either based on nutritional recommendations (like e.g. low carb) or based on substitutes like e.g. sweeteners. The use of replacers to reduce the salt (NaCl), sugar (sucrose, glucose, and fructose) and fat (saturated and trans-fatty acids) content has been very attractive for the food industry as it is an approach which requires only low cost in terms investments (no equipment needed) and ingredients. However, most of the approaches felt due to lack of consumer acceptance due to a different taste perception of the products. The PLEASURE project will be the first project addressing this challenge from the processing side.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: ENV.2007. | Award Amount: 4.62M | Year: 2008

The multidisciplinary research teams in this consortium have played lead roles in establishing that fetal and childhood periods are vulnerable to environmental disruption leading to common reproductive disorders. This proposal will investigate: (1) connections between normal/abnormal perinatal reproductive development and maturation of reproductive function at puberty and in adulthood; (2) systemic gene-environment interactions underlying reproductive disorders taking account of genetic susceptibility, multiple exposures (e.g. mixtures of environmental chemicals) and their timing (perinatal, peripubertal, adult); (3) connection between perinatal reproductive development and later obesity/metabolic disorders. To achieve this we will utilize large cohorts generated in previous EU projects and collect new data from these on reproductive maturation and adult function. Existing genomic and proteomics data, exposure data for >100 potentially toxic environmental chemicals, lifestyle, dietary and medical history information will be analysed using integrative systems biology approaches to pinpoint critical (interacting) factors influencing development. Established animal models will be used to test putative mechanisms by analysing the roles of neuroendocrine regulation, intrauterine growth, time windows of reproductive development, metabolic balance and xenobiotic metabolism. Toxicogenomics, proteomics and metabolomics results from these studies will identify pathways for study in the human cohorts. The overall aim is to create new cause-effect frameworks and knowledge networks to refine research in this critical area and to identify novel biomarkers of exposure and disease. The proposed studies will facilitate prediction and prevention of reproductive disorders and provide large new datasets and exposure-outcome information to improve environmental risk assessment and risk management.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: KBBE-2008-2-5-03 | Award Amount: 1.17M | Year: 2009

AgriFoodResults intends to answer the need for a better dissemination of food results. The vision is to improve the cost effectiveness of agri-food research activities by enhancing the transfer of the results to the end-users. The project combines capacity building with the creation of sustainable services for dissemination managers. Theses services include web-sites, innovative approach to communicate scientific results and guidelines for project and dissemination managers. The scope of AgriFoodResults is food science with an emphasis on food safety, food processing technology and nutrition & health. The focus is primary on SMEs and small research projects. AgriFoodResults has three main objectives: 1) To offer innovative and sustainable services for dissemination 2) To raise skills of European food scientists on dissemination practices 3) To successfully disseminate recent results from agri-food research projects. The consortium includes seven leading research organisations in food science, five organisations involved in knowledge transfer, management and communication of research projects, one company specialised in web development, an association of food enterprises and a European organisation specialised in food science communication.

Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.2.6-01 | Award Amount: 1.85M | Year: 2014

The LEO project will enable small-to-medium sized oven producers and bakeries to exploit two key research results from the completed FP6 EU-FRESHBAKE project, Freshly Baked Breads with Improvement of Nutritional Quality and Low Energy Demanding for the Benefit Of the Consumer and of the Environment (Project no. 036302). The key results to be exploited in the LEO project consist in an Infrared oven technology developed for batch and conveyor oven. A prototype oven was built by ONIRIS and the use of only infrared lamps for heating was successfully demonstrated for baking dough during the EU FRESHBAKE project. Compared to a standard baking oven, the pre-heating step with the prototype oven required between 20-40% less specific energy with a gain in time up to 70%. The invention has been patented by ONIRIS in 2009 (WO 2011/006955-A2). Only laboratory scale demonstrator of the low energy oven technology was investigated during the EU FRESHBAKE project. However, the LEO project will enable the manufacture of prototypes and their testing in-situ within European bakeries. Also an assessment of their environmental, social and economic life-cycle impact will be conducted, and a market study and comprehensive business plans will be developed in close relation with all the actors of the value chain to optimise the spread of the technology on the market. This novel low energy IR oven has an excellent potential for commercial exploitation in the baking market. Small to medium-sized companies represent an important share - 40% - of European bake-off bakeries, and most of these bakeries use medium scale ovens similar to the conveyor oven envisaged in LEO . Also batch oven prototypes (deck and rack) will be constructed to target small traditional craft bakers which represent the bulk of the European baking industry.

Agency: European Commission | Branch: FP7 | Program: CP-FP-SICA | Phase: KBBE-2009-1-3-04 | Award Amount: 4.06M | Year: 2010

The proposal deals with the establishment of control measures for two major tick-borne diseases of small ruminants: theileriosis caused by Theileria lestoquardi and T. uilenbergi and babesiosis caused by Babesia ovis. The research programme aims at improving existing and producing new attenuated vaccines, designing subunit vaccines and capability building. To achieve these goals the proposal will assess parasite diversity and identify molecules associated with attenuation of parasite virulence to be included in the development of safe and efficacious live vaccines. For the design of a subunit vaccine parasite molecules will be identified and characterized involved in i) invasion of host cells ii) activation of CD4\ T cells and NK cells for the production of cytokines capable of activating macrophages for killing of the parasites and iii) activation of cytotoxic T-lymphocytes involved in killing of T. lestoquardi-infected leucocytes. For improvement of attenuated vaccines, a combination of vaccine with subunit vaccine will be examined for synergistic effects and reducing the need of a cold chain by improving storage conditions/ shelf life of vaccine will be aimed for. Groups working on Plasmodium are involved with the goal to benefit from the scientific and technological knowledge in this field and to translate it into tools and reagents for small ruminant piroplasms. Industrial expertise regarding vaccine development and delivery systems will be incorporated in the whole project. The impact of the vaccine to be produced against these emerging tick-borne diseases will be enormous, as they pose a great threat to livestock production, and a contribution will be made that will meet critical Millennium development goals: food security, food safety, poverty alleviation, animal welfare and environmental sustainability.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE.2012.1.4-04 | Award Amount: 4.04M | Year: 2012

Animal health status in organic dairy farming does not in all respect meet consumers expectations. Improvements are crucial to support consumers confidence and their willingness to pay premium prices. These are urgently needed to cover the higher production costs. Previous herd health planning concepts have prepared the ground for further advancements. However, recommended measures are often implemented only to an unsatisfactory degree, differing widely between farms, and resulting in an improper animal health status. The IMPRO project aims to substantially overcome weak points in current health management strategies on organic dairy farms and to increase the implementation of evidence based measures and to improve practice of health management. This will be achieved by a multidisciplinary and participatory approach to develop farm specific solutions regarding preventive measures and early treatment strategies. Researchers with a thorough experience in conducting applied research will aim for the following: to develop a participatory and farm-centric diagnostic tool for a sound diagnostic procedure at the farm level, identifying the most effective measures to improve animal health, to evaluate farm-specific costs and benefits of recommended measures, to optimise farm-specific allocation of available resources, and to emerge incentives, to examine the motivation and attitudes of farmer, advisor, and veterinarian directly involved in health management practice, to elaborate reference values for achievable standards with respect to animal health status, to develop a pro-active monitoring protocol aiming for improved effectiveness of preventive and treatment strategies and for a reduction in the use of allopathic remedies, to assess the manageability of alternative treatments according to the state-of-the-art, to develop a software-based tool including health monitoring, farm diagnostics procedures, cost-benefit calculation, and break-even analysis.

Agency: European Commission | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-IAPP-2008 | Award Amount: 1.05M | Year: 2009

The ability to increase milk production in cow by bovine somatotropin (BST) was first demonstrated in 1930s. The use of recombinant bovine somatotropin (rBST) in dairy cows has become a common practice in the Untied States (US) and many other countries as the commercial product became available in 1994. However the use and sale of rBST in the EU has never been approved and was banned in 1999 due to concerns on animal health and welfare, food safety and quality, and human health implication associated with the administration of rBST in dairy cows. Nevertheless, there are no direct methods available to date that are capable to detect rBST. The present proposal will, by the use of new technologies and a wide range of expertise, deliver a means of screening and confirming the presence of this unwanted growth promoter in milk. The collaboration within the project will bring together a university, a public institution and two private commercial diagnostic companies to produce novel solutions for monitoring the quality and safety of foods. The proposed research project will give an opportunity of Industry-Academia collaboration that will allow the transfer of high level scientific research into much needed commercial outputs. As a consequence, both academic and industrial partners as well as communities will all benefit, not only during the project but well beyond. The major research outcome will be the delivery of a rapid and simple screening test (dipstick and/or ELISA), a highly accurate and quantitative immuno-biosensor test, and a sensitive and specific chemical confirmatory test for rapid detection and unequivocal identification of the presence of rBST in milk. The formation of partnerships will strengthen the joint efforts to advance research in food safety and quality which benefits ultimately all partners involved, the consumers and the community as a whole.

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