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Patent
French National Institute for Agricultural Research, National School of Engineering in Agricultural and Food Industries | Date: 2013-06-12

The invention relates to a method for isolating muscle-derived stem cells that can be used in cell therapy, said method comprising the steps of (i) dissociating cells from at least one muscle sample, (ii) plating the cells obtained at the end of step (i) on a non-coated cell container, (iii) isolating the cells present in the supernatant of the non-coated cell container obtained at the end of step (ii), (iv) plating the cells obtained at the end of step (iii) on a coated cell container, (v) isolating the cells present in the supernatant of the coated cell container obtained at the end of step (iv), (vi) repeating, or not, the steps (iii) and (iv) at least one or two times, (vii) plating and culturing the cells isolated from the supernatant of the coated cell container obtained at the end of step (vi) until said cells have reached a confluence level of at least 50%, (viii) isolating, at the end of step (vii), the stem cells which can be used in cell therapy, wherein after expansion (a) at least 95% of said cells express CD44, CD73, (b) at least 95% of said cells express CD29, (c) at least 70% of said cells express CD90, and (d) said cells do not express CD4, CD8, CD34, CD45, CD31, CD1 17, CD144 and CD133. The invention also relates to said isolated stem cells and pharmaceutical compositions containing them.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.2.6-01 | Award Amount: 1.85M | Year: 2014

The LEO project will enable small-to-medium sized oven producers and bakeries to exploit two key research results from the completed FP6 EU-FRESHBAKE project, Freshly Baked Breads with Improvement of Nutritional Quality and Low Energy Demanding for the Benefit Of the Consumer and of the Environment (Project no. 036302). The key results to be exploited in the LEO project consist in an Infrared oven technology developed for batch and conveyor oven. A prototype oven was built by ONIRIS and the use of only infrared lamps for heating was successfully demonstrated for baking dough during the EU FRESHBAKE project. Compared to a standard baking oven, the pre-heating step with the prototype oven required between 20-40% less specific energy with a gain in time up to 70%. The invention has been patented by ONIRIS in 2009 (WO 2011/006955-A2). Only laboratory scale demonstrator of the low energy oven technology was investigated during the EU FRESHBAKE project. However, the LEO project will enable the manufacture of prototypes and their testing in-situ within European bakeries. Also an assessment of their environmental, social and economic life-cycle impact will be conducted, and a market study and comprehensive business plans will be developed in close relation with all the actors of the value chain to optimise the spread of the technology on the market. This novel low energy IR oven has an excellent potential for commercial exploitation in the baking market. Small to medium-sized companies represent an important share - 40% - of European bake-off bakeries, and most of these bakeries use medium scale ovens similar to the conveyor oven envisaged in LEO . Also batch oven prototypes (deck and rack) will be constructed to target small traditional craft bakers which represent the bulk of the European baking industry.


Grant
Agency: Cordis | Branch: FP7 | Program: BSG-SME | Phase: SME-2013-1 | Award Amount: 1.56M | Year: 2013

DeTECH21 will provide through SME led and directed research new forensic testing services based on metabolomic profiling which will identify the misuse of prohibited and licensed chemicals in bovine and equine animals. The new services which the SME partners will obtain from the project will offer an innovative approach to drug analysis based on the monitoring of biological responses to drug use in animals rather than on the direct detection of compounds which forms the basis of current testing. The administration of both legal and illegal drugs to animals destined for food production and performance sport competition continues to be an enormous challenge. Current testing typically analyses individual samples for a single specific drug and thus is inefficient and costly. These limitations have become evident through sport anti-doping enforcement where similar testing has proved ineffectual with individuals proven to have continually evaded detection despite sustained testing. These challenges have been identified by SME partners as challenges to their long-term business sustainability. DeTECH21 aims to deliver new services to increase SME competiveness, service cost-effectiveness and market reach. This will be achieved through the use of the skills of RTD partners in innovative sample profiling techniques and the skills of SME partners in the commercial provision of analytical services. The uniqueness and innovation of the DeTECH21 project will lie in the construction of metabolomic databases which can be used to identify animals which have been exposed to exogenous substances and assist in the identification of administered compounds. This 2 year project brings into collaboration key partners from across Europe who have come together with the joint objective of delivering what will be the first commercially available forensic test service based on metabolomic analysis applicable to food safety and performance animal applications.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: KBBE.2012.1.4-04 | Award Amount: 4.04M | Year: 2012

Animal health status in organic dairy farming does not in all respect meet consumers expectations. Improvements are crucial to support consumers confidence and their willingness to pay premium prices. These are urgently needed to cover the higher production costs. Previous herd health planning concepts have prepared the ground for further advancements. However, recommended measures are often implemented only to an unsatisfactory degree, differing widely between farms, and resulting in an improper animal health status. The IMPRO project aims to substantially overcome weak points in current health management strategies on organic dairy farms and to increase the implementation of evidence based measures and to improve practice of health management. This will be achieved by a multidisciplinary and participatory approach to develop farm specific solutions regarding preventive measures and early treatment strategies. Researchers with a thorough experience in conducting applied research will aim for the following: to develop a participatory and farm-centric diagnostic tool for a sound diagnostic procedure at the farm level, identifying the most effective measures to improve animal health, to evaluate farm-specific costs and benefits of recommended measures, to optimise farm-specific allocation of available resources, and to emerge incentives, to examine the motivation and attitudes of farmer, advisor, and veterinarian directly involved in health management practice, to elaborate reference values for achievable standards with respect to animal health status, to develop a pro-active monitoring protocol aiming for improved effectiveness of preventive and treatment strategies and for a reduction in the use of allopathic remedies, to assess the manageability of alternative treatments according to the state-of-the-art, to develop a software-based tool including health monitoring, farm diagnostics procedures, cost-benefit calculation, and break-even analysis.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 3.91M | Year: 2011

Approximately 80% of all products are or were a particle at some point in their processing lifetime. Particle and colloid technology has been described as the Growth Engine of Tomorrow with the market projected to grow from $2T to $10Tr over the next decade. Alongside with this challenge, the number of researchers active in powder technology is limited and only a few universities, public and private institutes are educating specialists in this field. PowTech ITN aims to integrate inter-sectoral and multidisciplinary research in particle and powder technology into the training of 15 highly skilled young researchers, to strengthen the competitiveness of food and pharmaceutical industry and to strengthen the European Research Area. The PowTech ITN has 20 partners (9 industry) and comprises a focused research programme and a graduate school. The Focused Research programme will use an engineering design approach applied to powder processing. The understanding and modelling of powder structure from a molecular to a macro disperse scale will be used to understand how powder properties/functionality are formed or modified during processing. This knowledge will be used to select the appropriate process for production of the structure of interest. The long-term aim is to develop innovative products and to provide tools allowing minimal pilot plant trials. The PowTech Graduate School is aligned with the research objectives of the project covering relevant S&T and personal skills courses but also an intensive and continuous training in collaboration with industry. In addition to the industrial secondments, the ESRs will have industrial training in different industries. An industrial mentor will be appointed to guide their Career development plan. The ESR will also be trained in Research Methodology through preparing a research plan for their work, and later in their project by developing a research plan, supervising a MSc student, and writing a Grant application.

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