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Decat P.,Ghent University | Zhang W.-H.,Ghent University | Moyer E.,University of Amsterdam | Cheng Y.,National Research Institute of Family Planning | And 7 more authors.
European Journal of Contraception and Reproductive Health Care | Year: 2011

BackgroundConsiderable sexual and reproductive health (SRH) challenges have been reported among rural-to-urban migrants in China. Predictors thereof are urgently needed to develop targeted interventions. Study designA cross-sectional study assessed determinants of unmet need for contraception using semi-structured interviews in two cities in China: Guangzhou and Qingdao. Results Between July and September 2008, 4867 female rural-to-urban migrants aged 1829 years participated in the study. Of these, 2264 were married or cohabiting. Among sexually-active women (n2513), unmet need for contraception was reported by 36.8 and 51.2 of respondents in Qingdao and Guangzhou, respectively; it was associated with being unmarried, having no children, less schooling, poor SRH knowledge, working in non-food industry, and not being covered by health insurance. A substantial proportion of unmarried migrants reported they had sexual intercourse (16.6 in Qingdao and 21.4 in Guangzhou) contrary to current sexual standards in China. Conclusion The study emphasises the importance of improving the response to the needs of rural-to-urban migrants and recommends strategies to address the unmet need for contraception. These should enhance open communication on sexuality, increase the availability of condoms, and improve health insurance coverage. © 2011 The European Society of Contraception and Reproductive Health.

Decat P.,Ghent University | Zhang W.-H.,Ghent University | Delva W.,Ghent University | Delva W.,Stellenbosch University | And 8 more authors.
European Journal of Contraception and Reproductive Health Care | Year: 2012

Background We conducted a comparative study in worksites to assess the impact of sexual health promoting interventions on contraceptive use among female rural-to-urban migrants. Study design In Qingdao ten manufacturing worksites were randomly allocated to a standard package of interventions (SPI) and an intensive package of interventions (IPI). The interventions ran from July 2008 to January 2009. Cross-sectional surveys at baseline and end line assessed the sexual behaviour of young female migrants. To evaluate the impact of the interventions we assessed pre- and post-time trends. Results From the SPI group 721 (baseline) and 615 (end line) respondents were considered. Out of the IPI group we included 684 and 603 migrants. Among childless migrants, self-reported contraceptive use increased significantly after SPI and IPI (adjusted odds ratio [aOR] 3.23; 95% confidence interval [CI] 1.52-6.84; p <0.01 and aOR 5.81; 95% CI 2.63-12.80; p <0.001, respectively). Childless migrants older than 22 years reported a greater use after IPI than after SPI. Conclusion Implementing current Chinese sexual health promotion programmes at worksites is likely to have a positive impact on migrant women working in the manufacturing industry of Qingdao. More comprehensive interventions seem to have an added value if they are well targeted to specific groups. © 2012 The European Society of Contraception and Reproductive Health.

Wang G.-F.,General Hospital of Jinan Military Area Command of PLA | Shi C.-G.,National Research Institute of Family Planning | Sun M.-Z.,Beijing Institute of Transfusion Medicine | Wang L.,Huazhong University of Science and Technology | And 4 more authors.
Cardiovascular Drugs and Therapy | Year: 2013

Purpose: We assessed whether tetramethylpyrazine (TMP), an active ingredient of Ligusticum wallichii Franchat, attenuates atherosclerosis (AS) development in rabbits and protects endothelial cells injured by ox-LDL. Methods: In vivo, rabbits subjected to atherosclerosis were treated with TMP (75 and 150 mg/kg) by oral gavage for 12 weeks. In vitro, rat aortic endothelial cells (RAECs) were stimulated by ox-LDL. Results: TMP treatment with 75 and 150 mg/kg significantly reduced the relative atherosclerosis area ratio in the aorta (0.41±0.042, 0.27±0.047 vs. 0.66±0.058 in AS), the ratio of intimal/medial thickness (0.54±0.09, 0.39±0.07 vs. 1.1± 0.3 in AS) and the number of monocytes in intimal (10.1± 2.8, 8.2±2.0 vs. 14.1±4.9 counts/mm2 in AS). TMP also decreased levels of TC (15±4.2 to 6.1±1.2 mmol/L), TG (1.8±0.3 to 1.08±0.24 mmol/L), LDL-C (20.1±4.3 to 10.2± 1.6 mmol/L) and increased HDL-C levels (0.40±0.08 to 0.85±0.17 mmol/L) in atherosclerosis rabbit plasma. TMP decreased the MCP-1 (187.3±38.4 to 86.1±17.2 pg/ml) and ICAM-1 (350.6±43.7 to 260.6±46.1 pg/ml) levels in plasma and inhibited LOX-1 expression in the rabbit aortas. Moreover, our in vitro study revealed that TMP suppressed monocyte adhesion to RAECs, inhibited RAEC migration, and down-regulated MCP-1 and ICAM-1 expression in ox- LDL-injured RAECs. Likewise, TMP inhibited LOX-1 and 5-LOX expression, and prevented nuclear accumulation of RelA/p65 and IκB degradation in ox-LDL-injured RAECs. Furthermore, TMP suppressed ox-LDL-induced activations of p-ERK, p-p38, and p-JNK MAPK. Conclusion: TMP produces a tangible protection in atherosclerosis and endothelial cells. TMP might be a potential protective agent for atherosclerosis. © Springer Science+Business Media New York 2013.

Yang Y.,Capital Medical University | Wang L.,National Research Institute of Family Planning | Wu Y.,Chinese Institute of Basic Medical Sciences | Su D.,National Research Institute of Family Planning | And 5 more authors.
Brain Research | Year: 2016

Neuroinflammation plays an important role in vascular dementia(VD). Our previous work showed that mammalian Ste20-like kinase 1 (MST1) and the gene for a downstream transcription factor, FOXO3, play major roles in lipopolysaccharide (LPS)-induced apoptosis in hippocampal neurons. The neurotoxic effects of LPS are derived from its ability to cause an inflammatory response. We also previously showed that Tanshinol (TSL) provides neuro-protection in a rat model of VD. The present study further explores the effects of TSL on the neuroinflammatory aspects of VD and investigates whether TSL affects the MST1-FOXO3signaling pathway. VD was induced in rats using transient bilateral coronary artery occlusion. Interleukin(IL)-1β, IL-6, and tumor necrosis factor (TNF)-α levels were measured using enzyme-linked immunoabsorbent assay kits. Cell apoptosis was assessed by Hoechst 33342 staining. Protein and mRNA levels were evaluated by western blotting and quantitative polymerase chain reaction, respectively. TSL improved working memory and significantly inhibited plasma and hippocampal protein levels of IL-1β, IL-6, and TNF-α in a rat model of VD. LPS induced apoptosis in hippocampal neurons and increasedMST1 and p-FOXO3 protein expression, whereas MST1 siRNA transfection almost completely reversed LPS-induced neuronal apoptosis, indicating that LPS-induced cytotoxicity in hippocampal neurons is associated with MST1. TSL protected against LPS-induced cell apoptosis and suppressed IL-1β, IL-6, and TNF-α mRNA and protein expression as well as MST1 and p-FOXO3 protein expression in neurons. The present study provided novel mechanisms by which TSL exerts its neuroprotective activity and indicates that TSL may be a potential neuro-protective agent in VD. © 2016 Elsevier B.V. All rights reserved.

Shi C.-G.,National Research Institute of Family Planning | Yang Y.-S.,Capital Medical University | Li H.,Capital Medical University | Zhang Y.,National Research Institute of Family Planning | And 4 more authors.
Journal of Asian Natural Products Research | Year: 2014

Tanshinol (3-(3',4'-dihydroxyphenyl)-(2R)-lactic acid, TSL) is widely used in traditional Chinese medicine for the treatment of cardiovascular and cerebrovascular diseases. Here, we assessed whether TSL protected hippocampus and attenuated vascular dementia (VD) development in rats. The behavioral analysis showed that TSL could decrease the distance and latency time, and increase the swim speed in water maze in rats subjected to VD. TSL remarkably increased acetylcholine level and decreased acetylcholinesterase activity in rats subjected to VD. Likewise, TSL remarkably decreased malondialdehyde and increased superoxide dismutase levels in rats subjected to VD. Furthermore, treatment with TSL reduced the level of dead neurons in dentate gyrus. In addition, TSL upregulated growth-associated protein 43 (GAP43) and vascular endothelial growth factor (VEGF) expression and downregulated phosphorylated Akt (p-AKt) and phosphorylated glycogen synthase kinase (p-GSK3β) expression in hippocampus in rats subjected to VD. These results suggest that TSL may be a potential compound in VD model. © 2014 Taylor & Francis.

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