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Chen H.-J.,National Taiwan University of Science and Technology | Chung C.-P.,National Taiwan University of Science and Technology | Chiang W.,National Taiwan University of Science and Technology | Lin Y.-L.,National Research Institute of Chinese Medicine | Lin Y.-L.,National Taiwan University
Food Chemistry | Year: 2011

Anti-inflammation-guided fractionation and purification were used to evaluate the bioactivity and components of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) bran. Results showed that the fraction with high phenolic and flavonoid contents from the ethanol extracts of adlay bran suppressed LPS-stimulated IL-6 and TNF-α secretions in a concentration-dependent manner in RAW 264.7 cells and murine peritoneal macrophages. Fifteen compounds, including a novel aurone derivative, two chromones, one dihydrochalcone, one chalcone, four flavanones, five flavones and one isoflavone, were isolated from the active fraction. The structure of the new compound was elucidated by spectroscopic methods, including 1D and 2D NMR and MS. All of the isolates are reported for the first time from adlay except naringenin. LC/MS was also provided as an analytical platform. Our results suggest that flavonoids in adlay bran, partially at least, contribute to its anti-inflammatory effect. Thus, adlay bran may be beneficial to the health of consumers. © 2010 Elsevier Ltd. All rights reserved. Source


Ng V.A.S.,De La Salle University - Manila | Agoo E.M.G.,De La Salle University - Manila | Shen C.-C.,National Research Institute of Chinese Medicine | Ragasa C.Y.,De La Salle University - Manila
Journal of Applied Pharmaceutical Science | Year: 2015

Chemical investigation of Cycas aenigma, a plant endemic to the Philippines, led to the isolation of a rare neolignan, 2-[2-hydroxy-5-(3-hydroxypropyl)-3-methoxyphenyl]-1-(4-hydroxy-3-methoxyphenyl)propane-1,3-diol (1), pinoresinol (2), and fatty alcohols (3) from the leaflets; and triglycerols (4), and a mixture of β-sitosterol (5a) and stigmasterol (5b) from the petiole and rachis. The structure of 1 was elucidated by extensive 1D and 2D NMR spectroscopy, while those of 2-5b were identified by comparison of their 1H and/or 13C NMR data with literature data. © 2015 Vincent Antonio S. Ng et al. Source


Ng V.A.S.,De La Salle University - Manila | Agoo E.M.G.,De La Salle University - Manila | Shen C.-C.,National Research Institute of Chinese Medicine | Ragasa C.Y.,De La Salle University - Manila
Journal of Applied Pharmaceutical Science | Year: 2015

Chemical investigation of the dichloromethane extracts of Cycas sancti-lasallei, a plant endemic to the Philippines, led to the isolation of squalene (1), β-sitosterol (2a), stigmasterol (2b), and triglycerides (3) from the sarcotesta; 2a, 2b, 3,and phytyl fatty acid esters (4) from the endotesta; 2a, 2b, 3,and β-sitosteryl fatty acid esters (5) from the sclerotesta; and 3 and 5 from the bark. The structures of 1-5 were identified by comparison of their 1H NMR and/or 13C NMR data with those reported in the literature. © 2015 Vincent Antonio Ng et al. Source


Ragasa C.Y.,De La Salle University - Manila | Caro J.L.,De La Salle University - Manila | Shen C.-C.,National Research Institute of Chinese Medicine
Journal of Applied Pharmaceutical Science | Year: 2014

Chemical investigation of the dichloromethane extract of the twigs of Artocarpus ovatus afforded lupeol (1a), α-amyrin (1b), β-amyrin (1c), lupeol fatty acid ester (2a), α-amyrin fatty acid ester (2b), β-myrin fatty acid ester (2c), betulin (3a), 3β, 28-Dihydroxyolean-12-ene (3b), oleanolic acid (4), β-sitosterol (5), and chlorophyll a (6). The structures of 1-6 were identified by comparison of their 1H and/or 13C NMR data with those reported in the literature. © 2014 Consolacion Y. Ragasa et al. Source


Ragasa C.Y.,De La Salle University - Manila | Caro J.L.,De La Salle University - Manila | Shen C.-C.,National Research Institute of Chinese Medicine
Der Pharma Chemica | Year: 2015

Chemical investigation of the dichloromethane extract of the leaves of Artocarpus ovatus Blanco led to the isolation of 3β-friedelinol (1), squalene (2), polyprenol (3), triacylglycerols (4), and chlorophyll a (5). The structures of 1-5 were identified by comparison of their 1H and/or 13C NMR data with those reported in the literature. Source

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