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Polyak A.,National Fjc Research Institute For Radiobiology And Radiohygiene Nrirr | Hajdu I.,BBS Nanotechnology Ltd. | Bodnar M.,BBS Nanotechnology Ltd. | Dabasi G.,Semmelweis University | And 3 more authors.
International Journal of Pharmaceutics | Year: 2014

A new biocompatible, biodegradable, self-assembled chitosan-based nanoparticulate product was successfully synthesized and radiolabeled with technetium-99m, and studied as a potential new SPECT or SPECT/CT imaging agent for diagnosis of folate receptor overexpressing tumors. In the present study we examined the conditions of a preclinical application of this labeled nanosystem in early diagnosis of spontaneously diseased veterinary patient using a human SPECT/CT device. The results confirmed that the nanoparticles accumulated in tumor cells overexpressing folate receptors, contrast agent revealed higher uptake in the tumor for a long time. Preclinical trials verified that the new nanoparticles are able to detect folate-receptor-overexpressing tumors in spontaneously diseased animal models with enhanced contrast. © 2014 Elsevier B.V. All rights reserved. Source

Polyak A.,National Fjc Research Institute For Radiobiology And Radiohygiene Nrirr | Das T.,Bhabha Atomic Research Center | Chakraborty S.,Bhabha Atomic Research Center | Kiraly R.,Oncology and Radiotherapy Institute | And 10 more authors.
Cancer Biotherapy and Radiopharmaceuticals | Year: 2014

The present article describes the preparation, characterization, and biological evaluation of Thulium-170 (170Tm) [T1/2=128.4 days; Eβ(max)=968 keV; Eγ=84 keV (3.26%)] labeled tin oxide microparticles for its possible use in radiation synovectomy (RSV) of medium-sized joints. 170Tm was produced by irradiation of natural thulium oxide target. 170Tm-labeled microparticles were synthesized with high yield and radionuclidic purity (>99%) along with excellent in vitro stability by following a simple process. Particle sizes and morphology of the radiolabeled particles were examined by light microscope, dynamic light scattering, and transmission electron microscope and found to be of stable spherical morphology within the range of 1.4-3.2 μm. The preparation was injected into the knee joints of healthy Beagle dogs intraarticularly for biological studies. Serial whole-body and regional images were taken by single-photon-emission computed tomography (SPECT) and SPECT-CT cameras up to 9 months postadministration, which showed very low leakage (<8% of I.D.) of the instilled particles. The majority of leaked radiocolloid particles were found in inguinal lymph nodes during the 9 months of follow-up. All the animals tolerated the treatment well; the compound did not show any possible radiotoxicological effect. These preliminary studies showed that 170Tm-labeled microparticles could be a promising nontoxic and effective radiopharmaceutical for RSV applications or later local antitumor therapy. © 2014, Mary Ann Liebert, Inc. Source

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