National Research Council Italy

www.nrc-cnrc.gc.ca
Milan, Italy

The National Research Council is the primary national research and technology organization of the Government of Canada, in science and technology research and development. The Minister of Industry is responsible for the National Research Council . The transformation of the NRC into an RTO that focuses on "business-led research" was part of the federal government's Economic Action Plan. On 7 May 2013, the NRC launched its new "business approach" in which it offered four business lines: strategic research and development, technical services, management of science and technology infrastructure and NRC-Industrial Research Assistance Program . With these services, NRC intends to shorten the gap between early stage research and development and commercialization. NRC now has over 30 approved programs. Wikipedia.


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Patent
National Research Council Italy | Date: 2015-05-21

The invention relates to an in vitro or in vivo method for diagnosing Pagets disease or bone tumors associated therewith or for determining the predisposition of a subject affected by Pagets disease of bone to develop a bone tumor, the method being based on the detection of a mutation in the nucleotide sequence of the ZNF687 gene or in the amino acid sequence of the protein encoded by the mutated ZNF687 gene. The invention also refers to isolated nucleic acids comprising the mutated nucleotide sequence of the ZNF687 gene or a portion thereof and the encoded amino acid sequences.


Patent
National Research Council Italy and University of Salento | Date: 2017-01-23

Method and related system for measuring physiological parameters of a human subject undergoing an olfactory stimulation comprising one or more smelling olfactory stimuli, where by means of said system and according to said method a human subject is undergone to said olfactory stimulation by sending said one or more smelling olfactory stimuli to the human subject; one or more physiological parameters of the human subject are recorded; and said olfactory stimulation and physiological parameters recording are synchronized.


Patent
National Research Council Italy and Humanitas Mirasole S.P.A. | Date: 2015-06-17

A process for the manufacture of a heart valve of polymer material which provides for the deposition of a polymer solution comprising a copolymer which is preferably a copolymer of poly(carbonato-urethane) fluoridate (F-PCU) and intracatenary polydimethylsiloxane (PDMS), a PDMS with a functional group outside the chain and a solvent onto a mould using a spray technique associated with phase inversion.


Patent
IRBM Science Park S.p.A., Cnccs Scarl Collezione Nazionale Dei Composti Chimici E Centro Screening and National Research Council Italy | Date: 2017-05-24

The present invention relates to a Perhexiline compound of formula (I): or a pharmaceutically acceptable salt thereof, for use in the treatment of a pathology caused by trematodes.


Patent
National Research Council Italy, L.E.S.S. and IRBM SCIENCE PARK S.p.A. | Date: 2015-07-16

The present invention relates to Perhexiline, or a pharmaceutically acceptable salt thereof, for use in the treatment of a pathology caused by trematodes.


Patent
CSIC - Institute of Refrigeration and National Research Council Italy | Date: 2017-06-14

Process for obtaining fluoride-doped citrate-coated amorphous calcium phosphate nanoparticles. This material has applications in biomedicine due to its biodegradability and bioactivity; it also promotes cell adhesion and osteogeneration. In dentistry, it may be used in toothpastes, mouthwashes, chewing gums, gels and fluoride varnishes as a remineralising agent of dentine and enamel. It is based on two solutions formed by calcium chloride and sodium citrate on the one hand, and by sodium monohydrogenophosphate and sodium carbonate with a fluoride compound on the other, which are mixed at room temperature. The process is eco-efficient and eco-friendly, as it does not leave any acid residue; it consists of a single stage and it is the first time that an amorphous calcium phosphate coated with citrate and doped with fluoride, which enhances its remineralising action, is obtained.


Patent
Sciuto, National Research Council Italy and Fidia Farmaceutici S.p.A. | Date: 2017-06-07

The present invention relates to a derivative of carnosine (-alanyl-L-histidine) having formula (1), obtained by the functionalization of hyaluronic acid with carnosine.


Patent
National Research Council Italy and University of Salento | Date: 2017-05-31

Method and related system for measuring physiological parameters of a human subject undergoing an olfactory stimulation comprising one or more smelling olfactory stimuli, where by means of said system and according to said method a human subject is undergone to said olfactory stimulation by sending said one or more smelling olfactory stimuli to the human subject; one or more physiological parameters of the human subject are recorded; and said olfactory stimulation and physiological parameters recording are synchronized.


Patent
National Research Council Italy | Date: 2017-03-24

The T cells specific to human collagen type II, one of the possible autoantigens, have a crucial role in the development of rheumatoid arthritis in the context of HLA-DR4. The protein-protein interactions between the T cell receptor (TCR) and the type II collagen linked to the allele MHC of class II HLA-DR4 may thus represent the target for the development of new drugs against rheumatoid arthritis. Using computational virtual screening techniques, families of pharmacologically active molecules have been identified that interfere with the TCR/collagen II-MHCII interaction. The compounds identified here open up new possibilities in the treatment of rheumatoid arthritis.


Patent
National Research Council Italy | Date: 2017-07-26

The present invention features modified human transcription factors capable of increasing utrophin expression, recombinant adeno-associated vectors for delivery of the modified human transcription factors, and methods of treating muscle diseases, including Duchennes muscular dystrophy.

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