St. John, Canada

The National Research Council is the primary national research and technology organization of the Government of Canada, in science and technology research and development. The Minister of Industry is responsible for the National Research Council . The transformation of the NRC into an RTO that focuses on "business-led research" was part of the federal government's Economic Action Plan. On 7 May 2013, the NRC launched its new "business approach" in which it offered four business lines: strategic research and development, technical services, management of science and technology infrastructure and NRC-Industrial Research Assistance Program . With these services, NRC intends to shorten the gap between early stage research and development and commercialization. NRC now has over 30 approved programs. Wikipedia.


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Patent
National Research Council Canada | Date: 2016-05-10

The present invention provides a pharmaceutical composition comprising at least one compound selected from the group consisting of (S)-isoproterenol, (S)-isoproterenol dipivalate, (S)N-ethylnoradrenaline, (S)N-n-Propylnoradrenaline, (S)N-Butylnoradrenaline, (R, S)N-tert-butylnoradrenaline, 1-(3, 4) dihydrooxylphenyl)-2-(isopropylamine)-1-(R, S)-butanol, (S)-1-(N-isopropyl)-3-methyldopamine and (R)-1-(N-isopropyl)-3-methyldopamine suitable. The pharmaceutical composition may be for topical application to ocular tissues.


Patent
National Research Council Canada | Date: 2016-05-10

The present invention provides a method for inhibiting angiogenesis in a human subject in need of such inhibition. The method comprises administering to the human subject an anti-angiogenic effective amount of a physiologically tolerated salt thereof, or any mixture of the compounds of formula (I) a physiologically tolerated salt thereof, a prodrug thereof, a physiologically functional derivative thereof or any mixture thereof as an anti-angiogenic agent. The anti-angiogenic agent should have greater lipophilicity than (S)-noradrenaline.


Patent
National Research Council Canada | Date: 2016-06-10

The present invention provides a single domain antibody (sdAb) scaffold comprising one or more than one non-canonical disulfide bond in the framework region (FR). The one or more than one non-canonical disulfide bond may be formed between cysteines introduced by mutations in FR2 and FR3. In the case where the sdAb scaffold is a V_(H), the Cys may be introduced at any one of positions 47-49 and any one of positions 67-71, based on Kabat numbering; in one example, the Cys may be introduced at positions 49 and 69, based on Kabat numbering. In the case where the sdAb scaffold is a V_(L), the Cys residues may be introduced at any one of positions 46-49 and any one of positions 62-66, based on Kabat numbering; in one example, the Cys residues may be introduced at positions 48 and 64, based on Kabat numbering.


Patent
National Research Council Canada | Date: 2016-08-12

Disclosed is a radiation curable polymer formulation and methods of producing a dielectric film having such a formulation. The radiation curable polymer formulation includes an acrylic monomer; a cross linking agent; and a photoinitiator. The polymer formulation is insoluble with an organic solvent, which is preferable in low cost high volume manufacturing of thin film transistors for flexible electronics.


Patent
National Research Council Canada | Date: 2015-03-04

A technique is provided for incorporating pneumatic control in centrifugal microfluidics. The technique involves providing a chip controller that has pressurized fluid supply lines for coupling one or more pressurized chambers of the controller with ports of a microfluidic chip. At least part of the chip controller is mounted to a centrifuge for rotation with the chip. A flow control device is provided in each supply line for selectively controlling the pressurized fluid supply, and is electrically controlled. Bubble mixing, on and off-chip valving, and switching are demonstrated.


Patent
National Research Council Canada | Date: 2016-12-09

A piezoelectric film having a porosity between 20 and 40%, a thickness ranging from tens of microns to less than a few millimeters can be used to form an ultrasonic transducer UT for operation in elevated temperature ranges, that emit pulses having a high bandwidth. Such piezoelectric films exhibit greater flexibility allowing for conformation of the UT to a surface, and obviate the need for couplings or backings. Furthermore, a method of fabricating an UT having these advantages as well as better bonding between the piezoelectric film and electrodes involves controlling porosity within the piezoelectric film.


Patent
Xerox and National Research Council Canada | Date: 2016-11-18

The present disclosure describes a polyester that contains plural pendant adjacent carboxylic acid or acid salt side groups for use in making a toner for use in imaging devices.


Patent
National Research Council Canada | Date: 2015-04-10

An air flow sensor is provided with an opening facing downstream and having a thin downstream facing edge to prevent condensation or buildup of moisture thereon. The sensor has been found to reduce entrainment of particles in a mixed phase stream. The sensor is suitable for mounting to an aircraft, and to determining air temperature and relative humidity.


Methods are provided for synthesis of abscisic acid and 8 analogues thereof (including an enantiopure 8-acetylene analogue) including methods wherein the previously reported first step of oxidation of 2,6-dimethylphenol (VI) to 2,6-dimethylbenzoquinone, mono ketal (VII) is replaced by a novel two step process comprising (i) oxidation of 2,6-dimethylphenol (VI) using potassium peroxymonosulfate with a catalytic amount of iodobenzene to produce 2,6-dimethylbenzoquinone (XVI) and (ii) ketalization of 2,6-dimethylbenzoquinone (XVI) using ethylene glycol, trimethylorthoformate with a catalytic amount of p-toluenesulfonic acid to produce 2,6-dimethylbenzoquinone, mono ketal (VII).


Patent
National Research Council Canada and Dow AgroSciences | Date: 2017-03-29

The present disclosure relates to the isolation, purification, and characterization of a diacylglycerol acyltransferase 2 (DGAT2), and genes encoding DGAT2, from algae. DGAT2 can incorporate very long chain polyunsaturated fatty acids in to triacylglycerol more efficiently than DGAT1. The disclosure concerns methods of regulating seed oil content, fatty acid synthesis and fatty acid composition using the DGAT2 gene and to tissues and plants transformed with the gene. The disclosure also relates to transgenic plants, plant tissues and plant seeds having a genome containing an introduced DNA sequence of the disclosure, and a method of producing such plants and plant seeds.

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