St. John, Canada

The National Research Council is the primary national research and technology organization of the Government of Canada, in science and technology research and development. The Minister of Industry is responsible for the National Research Council . The transformation of the NRC into an RTO that focuses on "business-led research" was part of the federal government's Economic Action Plan. On 7 May 2013, the NRC launched its new "business approach" in which it offered four business lines: strategic research and development, technical services, management of science and technology infrastructure and NRC-Industrial Research Assistance Program . With these services, NRC intends to shorten the gap between early stage research and development and commercialization. NRC now has over 30 approved programs. Wikipedia.


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Patent
National Research Council Canada and Dow AgroSciences | Date: 2017-03-29

The present disclosure relates to the isolation, purification, and characterization of a diacylglycerol acyltransferase 2 (DGAT2), and genes encoding DGAT2, from algae. DGAT2 can incorporate very long chain polyunsaturated fatty acids in to triacylglycerol more efficiently than DGAT1. The disclosure concerns methods of regulating seed oil content, fatty acid synthesis and fatty acid composition using the DGAT2 gene and to tissues and plants transformed with the gene. The disclosure also relates to transgenic plants, plant tissues and plant seeds having a genome containing an introduced DNA sequence of the disclosure, and a method of producing such plants and plant seeds.


Patent
National Research Council Canada | Date: 2016-10-24

wherein R is a -DDHep-3--L-Fuc-3--GlcNAc trisaccharide substituted with an 1,6-glucan linked to an 1,3-DD-heptan, and wherein the last DD-Hep residue of 1,3-DD-heptan is capped with -GlcNAc residue. Compositions comprising the compound, uses of the compound, and antibodies raised against the compound are also described.


Patent
National Research Council Canada | Date: 2016-12-21

An oscillating foil turbine has a foil having a first fluid dynamic surface for producing lift in a fluid flow, a support for the foil, and a second fluid dynamic surface, wherein the support allows for cyclic motion of the first and second surfaces with respect to each other. A driven member is provided to tap energy from flow throughout each cycle. Throughout at least part of the cyclic translation, the fluid dynamic surfaces are oriented sufficiently parallel, and separated by a distance that is sufficiently small, to achieve a substantial wing-in-ground effect.


Patent
National Research Council Canada | Date: 2016-10-05

Successful application of an engineered protein as therapeutics or in other industries would require the protein to have good expression level, good biophysical properties and often desired affinity to its target. The present invention provides s method of screening large numbers of protein candidates (PCs) in all three aspects simultaneously. PCs are fused to a protein anchor, which is captured by the target/antigen. The captured PCs are evaluated for their expression levels, biophysical properties and affinities using conventional methods.


Patent
National Research Council Canada | Date: 2017-01-11

The blood-brain barrier (BBB) prevents transport of molecules larger than 500 Daltons from blood to brain. Receptor-mediated transcytosis (RMT) facilitates transport across the BBB of specific molecules that bind receptors on brain endothelial cells that form the BBB. An insulin-like growth factor 1 receptor (IGFlR)-binding antibody or fragment thereof is identified that transmigrates the BBB by RMT. The antibody or fragment is used to deliver a cargo molecule across the BBB, wherein the cargo molecule may be a therapeutic or detectable agent. The antibody is a camelid VHH, prepared by immunizing a llama with a 933-amino acid IGF1R polypeptide. Humanized forms of the camelid VHH are also generated.


Patent
National Research Council Canada | Date: 2017-01-11

The blood-brain barrier (BBB) prevents transport of molecules larger than 500 Dal tons from blood to brain. Receptor-mediated transcytosis (RMT) facilitates transport across the BBB of specific molecules that bind receptors on brain endothelial cells that form the BBB. An insulin-like growth factor 1 receptor (IGF lR)-binding antibody or fragment thereof is identified that transmigrates the BBB by RMT. The antibody or fragment is used to deliver a cargo molecule across the BBB, wherein the cargo molecule may be a therapeutic or detectable agent. The antibody is a camelid VHH, prepared by immunizing a llama with a 933-amino acid IGF 1R polypeptide. Humanized forms of the camelid VHH are also generated.


Patent
National Research Council Canada and Groupe Graham International Inc. | Date: 2017-04-26

A flake-less molecular ink suitable for printing (e.g. screen printing) conductive traces on a substrate has 30-60 wt% of a C8-C12 silver carboxylate or 5-75 wt% of bis(2- ethyl-1-hexylamine) copper (II) formate, bis(octylamine) copper (II) formate or tris(octylamine) copper (II) formate, 0.1-10 wt% of a polymeric binder (e.g. ethyl cellulose) and balance of at least one organic solvent. Conductive traces formed with the molecular ink are thinner, have lower resistivity, have greater adhesion to a substrate than metal flake inks, have better print resolution and are up to 8 times less rough than metal flake inks. In addition, the shear force required to remove light emitting diodes bonded to the traces using Loctite 3880 is at least 1.3 times stronger than for commercially available flake-based inks.


Patent
National Research Council Canada and University of Ottawa | Date: 2016-11-17

The present invention relates to the cell-based production of bacterial nonulosonates and their biosynthetic precursors. Specifically, the present invention provides recombinant cells for the production of pseudaminic acid, legionaminic acid, UDP-2,4-diacetamido-2,4,6-trideoxy--L-altropyranose, and UDP-2,4-diacetamido-2,4,6-trideoxy--D-glucopyranose. Methods for producing the sugars are also provided.


Patent
National Research Council Canada | Date: 2017-05-03

Nucleic acid molecules from cannabis have been isolated and characterized and encode polypeptides having cannabichromenic acid synthase activity. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.


Patent
National Research Council Canada | Date: 2016-12-05

The present invention relates to a recombinant bacterium expressing an antigen that is translocated to the cytosol of a host organism, and uses thereof. To this end, the present invention provides a recombinant bacterium comprising a nucleic acid encoding an antigen that is translocated to the cytosol of a host cell utilizing Type Ill secretion system. The recombinant bacterium is generally chosen from intracellular pathogens that reside in the phagosome and fail to induce rapid T cell activation. The translocated antigen may be a viral antigen, a bacterial antigen, or a tumour antigen. Methods of imparting immunity using the recombinant bacterium are also provided.

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