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Gong S.,Hebei University of Technology | Yang P.,Hebei University of Technology | Song L.,National Research Center for Rehabilitation Technical Aids
Proceedings - International Conference on Electrical and Control Engineering, ICECE 2010 | Year: 2010

A controller for a intelligent prosthetic knee which consists of four bar linkage mechanism with fixed pneumatic cylinder is presented. To detect human motion parameters, local sensor of goniometer and hall sensor are adopted. To obtain a displacement of the conical valve correspond to current speed, a knowledge base is established by ILC(Iterative Learning Control) algorithm. To validate the effects of the trans-femoral prosthesis controller, preliminary experiment is conducted. The results indicate that amputee can walk with a increased level of biological realism. © 2010 IEEE. Source


Zhang X.-Y.,National Research Center for Rehabilitation Technical Aids
Advances in Intelligent and Soft Computing | Year: 2012

Basic concepts of intelligent assistive device, and product groups. intelligent prosthetics, intelligent wheelchair, intelligent mobility assistive device, intelligent home automation and environment control of assistive rehabilitation training robot for assistive device, intelligent life, intelligent assistive device development tasks and future trends. © 2012 Springer-Verlag GmbH Berlin Heidelberg. Source


Ding X.,Beihang University | Liu H.,Beihang University | Fan Y.,Beihang University | Fan Y.,National Research Center for Rehabilitation Technical Aids
Advanced Healthcare Materials | Year: 2015

Graphene possesses many unique properties such as two-dimensional planar structure, super conductivity, chemical and mechanical stability, large surface area, and good biocompatibility. In the past few years, graphene-based materials have risen as a shining star on the path of researchers seeking new materials for future regenerative medicine. Herein, the recent research advances made in graphene-based materials mostly utilizing the mechanical and electrical properties of graphene are described. The most exciting findings addressing the impact of graphene-based materials on regenerative medicine are highlighted, with particular emphasis on their applications including nerve, bone, cartilage, skeletal muscle, cardiac, skin, adipose tissue regeneration, and their effects on the induced pluripotent stem cells. Future perspectives and emerging challenges are also addressed in this Review article. The most exciting findings addressing the impact of graphene-based materials on regenerative medicine are highlighted, with particular emphasis on their applications including nerve, bone, cartilage, skeletal muscle, cardiac, skin, adipose tissue regeneration, and their effects on the induced pluripotent stem cells. Future perspectives and emerging challenges are also presented. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Yang W.,Zhejiang University | Zhang X.-F.,National Research Center for Rehabilitation Technical Aids | Yang C.-J.,Zhejiang University | Wu H.-J.,Zhejiang University
Zhejiang Daxue Xuebao (Gongxue Ban)/Journal of Zhejiang University (Engineering Science) | Year: 2014

Considering the increasing requirements of rehabilitation training for stroke patients and spinal cord injury (SCI) patients, this work analyzed the driving degrees of freedom of human lower limbs, and designed a lower extremity exoskeleton system based on treadmill, which combined the training experience of physiotherapists and the high-power, repeatability of robot. Based on the 5-bar human machine model, the dynamic equation was established and the driving torques of hip and knee joints were calculated, which could be used as reference of motor selection for corresponding joints. In order to get normal gait data on treadmill, optical motion capture system was used to obtain the data of feature points while a normal person was walking on the treadmill. And the 5-bar human machine model was used to obtain the gait data. The results were regarded as reference of standard gait data of the exoskeleton system. Clinical experiments were conducted, which proved the feasibility and reliability of the exoskeleton system, and the experimental results conformed to the symptom of the patients. This exoskeleton system provides stroke patients with a scientific training platform for rehabilitation. Source


Wang L.,Beihang University | Wang L.,National Research Center for Rehabilitation Technical Aids | Zhou G.,Beihang University | Liu H.,Beihang University | And 4 more authors.
Nanoscale | Year: 2012

While the advantages of nanomaterials are being increasingly recognized, their potential toxicity is drawing more and more attention and concern. In this study, we explore the toxicity mechanism of 20-30 nm rod-shaped hydroxyapatite (HA) nanoparticles in vitro and in vivo. The nanoparticles were prepared by precipitation and characterized by IR, XRD and TEM. Concentrations of 0 μg mL -1, 10 μg mL -1, 100 μg mL -1, 1 mg mL -1, and 10 mg mL -1 were applied to the MC3T3-E1 cells for viability (MTT-test). Based on the characteristic differences of the two methods of cell death, the morphological features of the MC3T3-E1 cell line co-cultured with nano-hydroxyapatite (n-HA) (10 mg mL -1) for 24 h were also observed by TEM. Furthermore, important serum biochemical markers and histopathological examinations were used to evaluate the potential toxicological effect of n-HA on the major organs of SD rats injected intraperitoneally with n-HA (33.3 mg kg -1 body weight). In the results, we found cell growth inhibition and apoptosis in MC3T3-E1 cells co-cultured with n-HA. Moreover, apoptosis but not necrosis was illustrated in liver and renal tissue by using histopathology slices and serum biochemical markers. It suggests that apoptosis may be the possible mechanism of n-HA toxicity and provides a better understanding of the biocompatibility of nanomaterials applied in human bone repair. © 2012 The Royal Society of Chemistry. Source

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