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Kaliyev R.,National Research Center for Cardiac Surgery | Kapyshev T.,National Research Center for Cardiac Surgery | Goncharov A.,National Research Center for Cardiac Surgery | Lesbekov T.,National Research Center for Cardiac Surgery | Pya Y.,National Research Center for Cardiac Surgery
ASAIO Journal | Year: 2015

Use of extracorporeal membrane oxygenation (ECMO) for severe cardiopulmonary failure has increased because of improved outcomes. A specially designed ECMO transport system allows for safe transport of patients over long distances. We report a 28-year-old pregnant woman (26 weeks gestation) with acute respiratory distress syndrome in whom ECMO support was necessary for survival, and she was transported to another facility 1,155 km away with the aid of the portable ECMO system. Transport was uneventful, and the patient's condition remained stable. Acute respiratory distress syndrome improved gradually until the patient was discharged from the hospital with excellent maternal and fetal outcome. © 2015 by the American Society for Artificial Internal Organs.


Bekbossynov S.,National Research Center for Cardiac Surgery | Medressova A.,National Research Center for Cardiac Surgery | Murzagaliyev M.,National Research Center for Cardiac Surgery | Salov R.,National Research Center for Cardiac Surgery | And 4 more authors.
Giornale Italiano di Cardiologia | Year: 2014

In Kazakhstan, geographical and cultural reasons do not favor the development of heart transplant activity. Thus, a surgical program for treatment of advanced, refractory heart failure was implemented, focusing the efforts on ventricular assist device (VAD) therapy. The program, supported and funded by the national healthcare system, is based on a single, highly specialized surgical Center for the operation, and on a regional infrastructure for outpatient follow-up. Regional VAD coordinators are educated by the National Center. They are in charge of regular patient check, anticoagulant and antiplatelet treatment prescription, and continuing patients' and caregivers' education, mainly regarding driveline exit site dressing and driveline stabilization. From November 2011 to November 2013, 95 patients received 100 devices, mainly for left ventricular support (LVAD): HeartMate II, n=70, HeartWare, n=25. Mean age was 49.5 years, and 87.37% of the patients were males. Most patients had INTERMACS profile 4 (55%), followed by 3 and 2 (17% each). Symptomatic and functional improvement are testified by changes from baseline to month 3 of NYHA functional class (from III-IV to I-II), results of the 6-min walk test (from 152 to 440 m), and NT-proBNP levels (from 6997 to 1126 pg/ml). Overall 1-year survival was 69%, with a trend for outcome improvement over time and a relationship with preoperative INTERMACS profile (1-year survival of 60% in patients with INTERMACS profile 1-2 vs 75% in those with INTERMACS profile 3-4). In summary, where and when a heart transplant program cannot be implemented, LVAD represents a realistic therapeutic alternative. The key points for a successful VAD program are a dedicated, highly specialized multidisciplinary team at the Cardiac Surgery Center, an infrastructure throughout the country for coordinated outpatient follow-up, adequate reimbursement for this activity, and support by the healthcare system. © 2014 Il Pensiero Scientifico Editore.


PubMed | National Research Center for Cardiac Surgery
Type: | Journal: Kardiologia polska | Year: 2016

The prevalence of hypertension in Kazakhstan is high and a majority of patients are not adequately controlled. Treatment with renal artery denervation could represent a useful therapeutic option for a subset of patients in Kazakhstan with resistant hypertension.To assess the impact of renal artery denervation in a cohort of patients from Kazakhstan with resistant hypertension.Between March 2012 and December 2013, 63 patients underwent renal artery denervation at our tertiary care center. Eligibility criteria were office blood pressure more than 160 mmHg systolic or more than 90 mmHg diastolic despite being treated with three or more antihypertensive medications, including a diuretic. Ambulatory blood pressure was measured at baseline and month 12 and monitoring also included impact on insulin resistance and renal function.There were significant decreases of 2524 mmHg for ambulatory systolic blood pressure during the daytime and of 2623 mmHg for ambulatory systolic blood pressure during the nighttime (p<0.0001). We observed significant decreases of 1214 mmHg for ambulatory diastolic daytime blood pressure and of 1114 mmHg in ambulatory diastolic nighttime blood pressure (p<0.0001). A decrease in creatinine clearance was observed from 100.2 33.6 ml/min at baseline to 90.2 22.8 ml/min at month 12 (p<0.001). Homeostasis model assessment - insulin resistance (HOMA-IR) decreased from 3.04.6 at baseline to 2.53.7 at 12 months (p=0.007).In this population renal artery denervation resulted in statistically and clinically significant blood pressure reduction at 12 months with minimal adverse events.


PubMed | National Research Center for Cardiac Surgery
Type: Case Reports | Journal: ASAIO journal (American Society for Artificial Internal Organs : 1992) | Year: 2015

Use of extracorporeal membrane oxygenation (ECMO) for severe cardiopulmonary failure has increased because of improved outcomes. A specially designed ECMO transport system allows for safe transport of patients over long distances. We report a 28-year-old pregnant woman (26 weeks gestation) with acute respiratory distress syndrome in whom ECMO support was necessary for survival, and she was transported to another facility 1,155 km away with the aid of the portable ECMO system. Transport was uneventful, and the patients condition remained stable. Acute respiratory distress syndrome improved gradually until the patient was discharged from the hospital with excellent maternal and fetal outcome.

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