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Popescu T.,University of Medicine and Pharmacy, Cluj-Napoca | Nenu I.,University of Medicine and Pharmacy, Cluj-Napoca | Aldea M.D.,University of Medicine and Pharmacy, Cluj-Napoca | Olteanu D.,University of Medicine and Pharmacy, Cluj-Napoca | And 7 more authors.
Life Sciences | Year: 2014

Key findings Malondialdehyde levels and cyclooxygenase (COX)-2 expression increased significantly in the group treated with Pcox after TSPP-PDT when compared with TSPP + IR group (p < 0.05, p < 0.001 respectively), in correlation with a decrease in glutathione levels (p < 0.05). The quantification of apoptosis, based on the TUNEL-assay, and necrosis rate revealed an increase of apoptotic/necrotic index in the same group (p < 0.05). On the other hand, Pcox administered before irradiation showed a significant increase in both vascular endothelial growth factor (VEGF) and COX-2 levels (p < 0.05) and in nitric oxide production (p < 0.01), when compared with the control group.Significance The administration of Pcox after TSPP-mediated PDT showed promising antitumoural effects, leading to an increase in oxidative and nitrosative stress as well as apoptosis/necrosis rate in tumour tissue. These results show that combined regimens that involve selective COX-2 inhibitors administration after irradiation may improve the therapeutic effectiveness of PDT.Aims The study investigated the effects of the combined treatment Parecoxib (Pcox) and 5,10,15,20-tetra-sulphonato-phenyl-porphyrin(TSPP)-mediated photodynamic therapy on Walker 256 carcinosarcoma.Main methods Five groups of male Wistar rats were used: the control group, treated with TSPP, group 2, irradiated 24 h thereafter, group 3, treated with Pcox and irradiated 24 h thereafter, groups 4 and 5 treated with combined therapies, TSPP and Pcox before irradiation, and Pcox 24 h after TSPP and irradiation respectively. Tumour inflammation, growth and non-growth factors, apoptosis/necrosis rate and oxidative/nitrosative stress markers were investigated. © 2014 Elsevier Inc. All rights reserved. Source

Caprarescu S.,Polytechnic University of Bucharest | Purcar V.,National Research AndDevelopment Institute for Chemistry and Petrochemistry ICECHIM | Sarbu A.,National Research AndDevelopment Institute for Chemistry and Petrochemistry ICECHIM | Radu A.-L.,National Research AndDevelopment Institute for Chemistry and Petrochemistry ICECHIM | And 2 more authors.
Revue Roumaine de Chimie | Year: 2015

A study of the Cu2+ removal from synthetic wastewater solutions, using different polymer ion exchanging membranes based on the copolymer acrylonitrile-vinyl acetate-α methyl styrene and containing small quantities of anion (Purolite A500) or cation exchange resins (Puropack PPC100) is presented. A three circular compartments electrodialysis cell was used. This electrodialysis unit worked under a constant applied voltage (9 V), in batch mode, with the electrolyte recirculation. The effect of initial copper ions concentration and flow rate on the duration of electrodialysis removal of copper ions was evaluated. The conductivity value, pH value and temperature of solution were measured at the end of electrodialysis. The percent extraction (PE) of copper ions and energy consumption were determinated. The results demonstrated that the ion removal rates from the synthetic solution increased with solution flow rate and the PE of copper ions increased over 88%, when initial copper ions concentration was high (4 g/L). The optimal flow rate and energy consumption values to remove copper ions are reported. © 2015, Editions de l'Academie Republique Populaire. All rights reserved. Source

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