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Velinov T.,National Reference Laboratory for Control and Monitoring of Antimicrobial Resistance | Todorova B.,National Reference Laboratory for Control and Monitoring of Antimicrobial Resistance | Petrov M.,National Reference Laboratory for Control and Monitoring of Antimicrobial Resistance | Dimitrova V.,National Reference Laboratory for Control and Monitoring of Antimicrobial Resistance | Kantardjiev T.,National Reference Laboratory for Control and Monitoring of Antimicrobial Resistance
Problems of Infectious and Parasitic Diseases | Year: 2010

Background: Tigecycline is a new injectable glycylcycline antibacterial product with potent activity and broad spectrum against Gram-positive and Gram-negative bacteria currently used for the treatment of complicated skin and skin structure-infections and intra-abdominal infections. We evaluated the in vitro activity of this compound against clinical strains of Gram-positive and Gram-negative species collected from Bulgarian medical centers in the National Reference Laboratory for Control and Monitoring of Antimicrobial Resistance at the NCIPD. Methods: A total of 187 non-duplicate clinical strains from different medical centers were tested for susceptibility by reference broth microdilution methods according to Clinical and Laboratory Standards Institute guidelines and interpretative criteria. Results: All S. aureus strains were inhibited at a tigecycline MIC of £0.5 μg/ml. Among the tested Enterococcus strains the highest tigecycline MIC value was 0.25 μg/ml. Similarly ESBL producing E. coli and K. pneumoniae exhibited uniformly susceptibility to this compound with MIC values reaching 2 μg/ml only for some strains K. pneumoniae. Among the multiple drug resistant A. baumannii strains collected, our assessment indicated MIC 90 value of 2 μg/ml. Conclusion: Tigecycline showed highly potent in vitro activity against all clinical strains tested and appears to be an excellent therapeutic option for serious infections caused by difficult-to-treat microorganisms. The present study did not detect any tigecycline-resistant strains with the exception of a single A. baumannii isolate with MIC value of 8 μg/ml.

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