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Toulouse, France

Founded in 1969, the National Polytechnic Institute of Toulouse is a French university system based in Toulouse, France part of University of Toulouse.The Institute is composed of seven schools and 17 research laboratories. The Institute delivers Master's degrees and Ph.D. It is member of Institut au service du spatial, de ses applications et technologies. Wikipedia.


Hureau C.,CNRS Coordination Chemistry | Hureau C.,National Polytechnic Institute of Toulouse
Coordination Chemistry Reviews | Year: 2012

Metal ions, mainly copper, zinc and iron, have been involved in several processes associated with the etiology of Alzheimer disease (AD). Amyloid deposits found in AD patients' brains, known as senile plaques, are one of the morphological hallmarks of this neurodegenerative disorder. They are mostly constituted of aggregated and fibrillar forms of amyloid-β (Aβ) peptides but also contain high concentrations of metal ions (in the mM range). Because the Aβ peptide in its monomeric soluble form exist in healthy patients, step(s) in the process leading to the formation of the senile plaques is(are) key for the Aβ neurotoxicity. Aβ is obtained by specific cleavage of the Amyloid Precursor Protein (APP). Both Aβ peptides and APP contain metal ions binding sites and metal ions coordination may impact their intrinsic properties. For instance, in the case of Aβ peptides, metal ions modulate Aβ aggregation propensity and redox properties of redox active ions such as copper and iron are altered by binding to Aβ.The main objective of the present review is to give an overview of the structural evidence available nowadays concerning coordination to APP and Aβ peptides of redox active ions, i.e. copper(I/II) and iron(II/III). Copper(II) site in the so-called copper binding site of APP was determined by X-ray crystallography and is {Nimτ(His147)Nimπ(His151),PhO-(Tyr168),2Owater}. More recently, in APP, a copper(II) site made of four imidazole rings from His outside the copper binding domain was characterized by X-ray diffraction. Two copper(II) sites in Aβ co-exist at physiological pH, noted components I and II, where I (resp. II) is predominant at lower (resp. higher) pH. In I and II, the equatorial binding sites of copper(II) are {NH 2 (Asp1), CO (Asp1-Ala2), N im (His6), N im (His13 or His14),} and {NH 2 (Asp1), N - (Asp1-Ala2), CO (Ala2-Glu3), N im (His6 or His13 or His14)}, respectively. Copper(I) is linearly bound to Aβ via two imidazole rings from the His residues. Such highly different environments of copper in its two redox states impact the properties of the copper redox couple and will be briefly commented on in the present review. Regarding iron binding to APP and Aβ, preliminary data, which essentially show that iron(II) is the sole redox state able to interact with APP and Aβ, are described. © 2012 Elsevier B.V. Source


Chemical-looping combustion (CLC) has unique potential for reducing energy and cost penalty for CO2 capture, as it avoids the costly gas separation of other CO2 capture technologies. Early deployment is seen in natural gas steam generation, where gas-to-steam efficiency penalty with CLC is below 1%-point compared to 15%-points with amine scrubbing and 8%-points with oxyfuel combustion, all for 95% capture rate. Reduction of the CO2 avoidance cost of 60% compared to amine scrubbing post combustion capture results from higher efficiency. An absolute necessity for the scale-up of reactors for this technology is the availability of adequate oxygen carrier material. SUCCESS will assure scale-up of oxygen-carrier production to the 100 tonne scale, as well as scale up of technology to 1 MW. Industrially available raw materials will be used to produce environmentally sound oxygen carriers based on two highly successful materials developed of the previous INNOCUOUS project. The work includes, i) applying the oxygen carrier production methods at industrially required scale and assuring the adequate performance, ii) development of standard for mechanical stability, iii) validation operation in four available smaller pilots <150 kW, of significantly different design iv) operation with gaseous fuels in a 1 MW pilot plant, representing a scale up of the state of art by one order of magnitude. v) detailed studies of reaction mechanisms and fluid-dynamics vi) use of results in optimization of a previous design for a 10 MW demonstration plant and techno-economic study of full-scale plant vii) assessment of health, safety and environmental issues associated with oxygen carrier handling including reuse or recycling strategies. viii) quotations for production of >100 tonnes of material Combined efforts of key European developers of CLC technology will assure the continued European leadership in this development and bring the technology a major step towards commercialization.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: WASTE-4d-2015 | Award Amount: 1.50M | Year: 2015

Refractory metals (tungsten, tantalum, rhenium, molybdenum and niobium) are highly strategic metals today mainly imported from a few countries. The European primary production remains below a few percentage. However, resources exist in Europe, as primary resources but mainly as secondary resources (industrial waste, urban mines). Valorizing these resources requires coordination and networking between researchers, entrepreneurs and public authorities to harmonise technologies, processes and services, develop standards, create new potential for export of eco-innovative solutions and for seizing new markets. MSP-REFRAM will address these challenges by creating of a common multi-stakeholder platform that will draw the current refractory metals value chains and identify its innovation potential in order to support the implementation of the EIP on Raw Materials. Coming from industry, research, public sectors and civil society, both Consortium Members and External Experts have joined forces with expertise covering the whole value chain including mining, processing, recycling, application. The outputs of MSP-REFRAM will help Europe improve the supply value chain of refractory metals in the coming years, optimising the use of external resources as energy and water and at the same time reducing the amount and the toxicity of waste. MSP-REFRAM will share its conclusions widely and efficiently, in a long lasting way thanks to the support of the PROMETIA association. To ensure the systemic change, the outcomes of the project will be made available to the stakeholders and to the public through different tools and reports. In the medium term, MSP-REFRAM will contribute to better-informed decision-making at EU and national level as well as industry by proposing innovative value chains that will boost the refractory metals sector. In the longer term, this should improve the availability of these refractory metals, while creating greater added value to the economy and more jobs.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: ICT-18-2014 | Award Amount: 1.30M | Year: 2015

European film makers are well-known for their creative innovation in selecting themes, their original way of storytelling and their art of cinematography. Like elsewhere in the world, they use computer-generated visual effects to achieve the intended visual experience and quality. To achieve the best interaction between the creative team on set and the post-production team, it is important to achieve the best common understanding between the team filming real scenes and the team working on visual effects. For this, previz has been developed. Previz today contributes to film making from the planning stage to filming with actors on set, where the final composition of mixed reality scenes can be reviewed during and right after the shoot. Large film studios that produce films with the highest budgets take the final step and integrate previz with the final post-production. For this, they develop in-house tools or cooperate with a company that is dedicated to the previz concept. This integration remains unavailable to most film makers and provides a strong competitive advantage. Without the integration, a gap remains between the team filming real scenes and the team working on visual effects in post-production. POPART will introduce an affordable and highly customizable solution that will disrupt the market and overcome this lack of competition. It will democratize the access to a complete previz solution integrated into the pipeline from shooting preparation to post-production, that doesnt exist on the market. In contrast to the market lock-in solutions, all core elements required for real-time previz will be released in open source and will be based on open standards to provide an highly customizable solution. The product released by POPART will comprise hard- and software components. It will be available at an affordable price, help improve the processes for creative teams in Europe directly, and will stimulate research by providing core libraries in open source.


The world demographic growth and global climate change are major challenges for human society,hence the need to design new strategies for maintaining high crop yield in unprecedented environmental conditions.The objective of TomGEM is to design new strategies aiming to maintain high yields of fruit and vegetables at harsh temperature conditions, using tomato as a reference fleshy fruit crop.As yield is a complex trait depending on successful completion of different steps of reproductive organ development, including flower differentiation and efficient flower fertilization,TomGEM will use trans-disciplinary approaches to investigate the impact of high temperature on these developmental processes.The core of the project deals with mining and phenotyping a vast range of genetic resources to identify cultivars/genotypes displaying yield stability and to uncover loci/genes controlling flower initiation,pollen fertility and fruit set.Moreover,since high yield and elevated temperatures can be detrimental to quality traits,TomGEM will also tackle the fruit quality issue.The goal is to provide new targets and novel strategies to foster breeding of new tomato cultivars with improved yield.The main strength of TomGEM resides in the use of unique and unexplored genetic resources available to members of the consortium.It gathers expert academic researchers and private actors committed to implement a multi-actor approach based on demand driven innovation.Tomato producers and breeders are strongly involved from design to implementation of the project and until the dissemination of results.TomGEM will provide new targets and novel strategies to foster the breeding of new tomato cultivars with improved yield under suboptimal temperature conditions.TomGEM will translate scientific insights into practical strategies for better handling of interactions between genotype,environment and management to offer holistic solutions to the challenge of increasing food quality and productivity.

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