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Ghasemlou M.,Michigan State University | Aliheidari N.,University of Tehran | Shojaee-Aliabadi S.,National Nutrition and Food Technology Research Institute | Keshavarz B.,Florida State University | And 2 more authors.
Carbohydrate Polymers | Year: 2013

Corn starch-based films are inherently brittle and lack the necessary mechanical integrity for conventional packaging. However, the incorporation of additives can potentially improve the mechanical properties and processability of starch films. In this work two essential oils, Zataria multiflora Boiss (ZEO) or Mentha pulegium (MEO) at three levels (1%, 2% and 3% (v/v)), were incorporated into starch films using a solution casting method to improve the mechanical and water vapor permeability (WVP) properties and to impart antimicrobial activity. Increasing the content of ZEO or MEO from 2% to 3% (v/v) increased values for elongation at break from 94.38% to 162.45% and from 53.34% to 107.71% respectively, but did not significantly change tensile strength values of the films. The WVP properties of the films decreased from 7.79 to 3.37 or 3.19 g mm m-2 d-1 kPa-1 after 3% (v/v) ZEO or MEO incorporation respectively. The oxygen barrier properties were unaffected at the 1% and 2% (v/v) oil concentration used but oxygen transmission increased with 3% (v/v) for both formulations. The films' color became slightly yellow as the levels of ZEO or MEO were increased although transparency was maintained. Both films demonstrated antimicrobial activity with films containing ZEO more effective against Escherichia coli and Staphylococcus aureus than those containing MEO. These results suggest that ZEO and MEO have the potential to be directly incorporated into corn starch to prepare antimicrobial biodegradable films for various food packaging applications. © 2013 Elsevier Ltd. All rights reserved.


Rastmanesh R.,Shahid Beheshti University of Medical Sciences | Rastmanesh R.,National Nutrition and Food Technology Research Institute
Contemporary Clinical Trials | Year: 2011

Malnutrition and weight loss are common in patients with cancer, both factors could potentially affect the response and tolerance to treatment, decreased quality of life, and thus associate them with poor survival. Conjugated linoleic acid (CLA) is shown to have beneficial health effects in healthy and disease situations including chemoprotective properties in various experimental cancer models. However, the anticarcinogenic property of CLA in animal and tissue culture models could not be confirmed in the Netherlands Cohort Study on Diet and Cancer and a prospective cohort of Swedish women. Cancer patients are already at increased risk of anorexia and there are evidences that CLA suppresses appetite even in healthy individuals. Risk/benefit analysis of CLA supplementation has never been reported before and it is not clear whether any beneficial anti-tumor effect of CLA prevails over its anti-appetite and/or weight lowering side effect in these patients. I suggest that clinical trials investigating CLA supplements in cancer patients, measure appropriate variables such as food intake, weight, and appetite change to yield preliminary data for future trials. I also suggest that data from previous trials that have administered CLA supplements to cancer patients be re-analyzed retrospectively to attempt to find out any effect from routine nutritional measures such as weight, serum albumin and such as those. © 2010 Elsevier Inc.


Kooshki A.,Sabzevar University of Medical science | Taleban F.A.,Shahid Beheshti University of Medical Sciences | Tabibi H.,Shahid Beheshti University of Medical Sciences | Tabibi H.,National Nutrition and Food Technology Research Institute | Hedayati M.,Shahid Beheshti University of Medical Sciences
Annals of Nutrition and Metabolism | Year: 2011

Background and Aims: High concentrations of serum inflammation markers, especially vascular inflammation markers, are an important risk factor for cardiovascular diseases in hemodialysis patients. The present study was designed to investigate the effects of marine omega-3 fatty acids on serum systemic and vascular inflammation markers and oxidative stress in hemodialysis patients. Methods: Thirty-four hemodialysis patients were randomly assigned to either the marine omega-3 fatty acid or the placebo group. Patients in the omega-3 fatty acid group received 2,080 mg marine omega-3 fatty acids daily for 10 weeks, whereas the placebo group received a corresponding placebo.At baseline and the end of week 10, 5 ml blood was collected after a 12- to 14-hour fast. Results: Mean serum soluble intercellular adhesion molecule type 1 (sICAM-1) decreased significantly in the omega-3 fatty acid group at the end of week 10 compared to baseline (p < 0.05) and this reduction was significant in comparison with the placebo group (p < 0.05). No significant differences were observed between the two groups in mean changes in serum soluble vascular cell adhesion molecule type 1, sE-selectin, sP-selectin, C-reactive protein, interleukin-6, tumor necrosis factor-α, malondialdehyde and total antioxidant capacity. Conclusion: The results of the present study indicate that marine omega-3 fatty acids can reduce serum sICAM-1, a risk factor for cardiovascular diseases, but it has no effect on serum systemic inflammation markers and oxidative stress in hemodialysis patients. Copyright © 2011 S. Karger AG, Basel.


Khalatbari Soltani S.,University Putra Malaysia | Jamaluddin R.,University Putra Malaysia | Tabibi H.,National Nutrition and Food Technology Research Institute | Mohd Yusof B.N.,University Putra Malaysia | And 3 more authors.
Hemodialysis International | Year: 2013

Inflammation and lipid abnormalities are two important risk factors for cardiovascular disease in hemodialysis (HD) patients. The present study was designed to investigate the effects of flaxseed consumption on systemic inflammation and serum lipid profile in HD patients with lipid abnormalities. This was an unblinded, randomized clinical trial. Thirty HD patients with dyslipidemia (triglyceride >200mg/dL and/or high-density lipoprotein-cholesterol (HDL-C) <40mg/dL) were randomly assigned to either a flaxseed or control group. Patients in the flaxseed group received 40g/day ground flaxseed for 8 weeks, whereas patients in the control group received their usual diet, without any flaxseed. At baseline and at the end of week 8, 7mL of blood was collected after a 12- to 14-hour fast and serum concentrations of triglyceride, total cholesterol, low-density lipoprotein-cholesterol (LDL-C), HDL-C, and C-reactive protein (CRP) were measured. Serum concentrations of triglyceride (P<0.01), total cholesterol (P<0.01), LDL-C (P<0.01), and CRP (P<0.05) decreased significantly in the flaxseed group at the end of week 8 compared with baseline, whereas serum HDL-C showed a significant increase (P<0.01). These changes in the flaxseed group were significant in comparison with the control group. The study indicates that flaxseed consumption improves lipid abnormalities and reduces systemic inflammation in HD patients with lipid abnormalities. Hemodialysis International © 2012 International Society for Hemodialysis.


Asgharzadeh A.,Gorgan University of Agricultural Sciences and Natural Resources | Shabanpour B.,Gorgan University of Agricultural Sciences and Natural Resources | Aubourg S.P.,CSIC - Institute of Marine Research | Hosseini H.,National Nutrition and Food Technology Research Institute
Grasas y Aceites | Year: 2010

Silver carp (Hypophthalmichthys molitrix) has acquired great attention because of its increasing farming production and application in the surimi-product commercialization. This work focuses on the effect of a washing process followed by frozen storage (6 months; -18 C) on the quality of minced silver carp muscle. A previous washing step has led to a positive effect on fish quality according to marked content decreases in expressible moisture, volatile amines, free fatty acids and thiobarbituric acid reactive substances; such quality performances were maintained throughout the frozen storage. On the other hand, most indexes tested showed quality losses throughout the frozen storage in both washed and unwashed fish material; however, water holding capacity (WHC) remained unchanged in washed fish throughout the frozen storage. Among quality indexes, a special attention should be given to the expressible moisture value and accordingly the WHC, as being closely related to the gelforming ability in order to obtain surimi-type commercial products.


Salarbashi D.,Islamic Azad University at Sabzevar | Tajik S.,Gorgan University of Agricultural Sciences and Natural Resources | Ghasemlou M.,Michigan State University | Shojaee-Aliabadi S.,National Nutrition and Food Technology Research Institute | And 2 more authors.
Carbohydrate Polymers | Year: 2013

This study examines the development of new bio-active polysaccharide-based bioplastics through casting and solvent-evaporation. Soluble soybean polysaccharide (SSPS) films incorporated with Zataria multiflora Boiss (ZEO) or Mentha pulegium (MEO) at various concentrations were prepared and characterized. The presence of ZEO and MEO improved polysaccharide interactions, reducing the films' water solubility and water vapor barrier properties, but did not markedly modify their moisture content or thickness. Differing amounts of ZEO or MEO had no significant effect on mechanical behavior, with the exception of 3% oil concentration, which decreased tensile strength and significantly increased elongation at break. DMTA curves revealed a single Tg, which may indicate the compatibility of essential oil and SSPS. The electron scanning micrograph for the composite film was homogeneous, without signs of phase separation between the components. These results suggest that ZEO and MEO can potentially be directly incorporated into SSPS to prepare active biodegradable films for food-packaging applications. © 2013 Elsevier Ltd. All rights reserved.


Pirouzpanah S.,Tabriz University of Medical Sciences | Taleban F.-A.,National Nutrition and Food Technology Research Institute | Mehdipour P.,Tehran University of Medical Sciences | Atri M.,Tehran University of Medical Sciences | Foroutan-Ghaznavi M.,Tabriz University of Medical Sciences
Nutrition and Cancer | Year: 2014

Recently the elevated plasma total homocysteine (tHcy) concentration has been concerned as the secondary feature of tumoral proliferation and enhances the likelihood of thrombogenesis in cancer patients. The objective of this study was to determine the associations between folate, cobalamin, and pyridoxine with fasting plasma tHcy concentration in breast cancer (BC) patients. The intake levels of nutrients were assessed using a validated food frequency questionnaire in 141 newly diagnosed BC patients. The plasma tHcy and pyridoxal-5-phosphate were measured using high performance liquid chromatography with fluorescence detector. Plasma tHcy levels were observed to be significantly higher among BC participants with Stage III where the plasma concentrations of folate was also comparatively less (P < 0.05) than other stages. Dietary pyridoxine was even being consumed less at this stage (P < 0.05). The plasma, dietary, and residual variables of folate were inversely correlated with plasma tHcy concentration (P < 0.05). Dietary cobalamin was also associated negatively with tHcy (P < 0.05). The odds ratio of comparing the highest tertile of plasma cobalamin (>394 pmol/l) and folate (>11.4 ng/ml) vs. the lowest categories were associated with reduced odds of high tHcy occurrence with 0.20 (95% confidence interval: 0.04-0.98) and 0.14 (95% confidence interval: 0.03-0.64), respectively. In conclusion, nutrition-related methyl-group insufficiency could lead to imbalance in tHcy metabolism, as a possible cancer marker. © 2014 Taylor and Francis Group, LLC.


Neyestani T.R.,National Nutrition and Food Technology Research Institute | Djazayery A.,Tehran University of Medical Sciences | Shab-Bidar S.,Tehran University of Medical Sciences | Eshraghian M.R.,Tehran University of Medical Sciences | And 8 more authors.
Diabetes Care | Year: 2013

OBJECTIVEdInterpopulation as well as interindividual variations in response to vitamin D intake commonly observed in subjects with type 2 diabetes may be related to genetic makeup. One of the candidate genes potentially responsible for this diversity is vitamin D receptor (VDR). This study aimed to investigate the interactive effect of VDR Fok-I polymorphism and vitamin D intake on diverse aspects of diabetic host response. RESEARCH DESIGN AND METHODSdGlycemic status, lipid profiles, inflammatory biomarkers, and VDR Fok-I genotypes were determined in diabetic subjects (n = 140) who participated in a randomized controlled trial. Participants consumed two 250-mL bottles per day of yogurt drink (doogh) fortified with 500 IU vitamin D/250 mL for 12 weeks. RESULTSdMean serum25(OH)Dincreased by ~30 nmol/L (P,0.001). The time3intervention effect was significant for 25(OH)D (P = 0.030),HDL (P = 0.011), high-sensitivity C-reactive protein (hsCRP) (P < 0.001), interleukin (IL)-4 (P = 0.008), and IL-6 (P = 0.017) among the genotypic groups. The alleles were defined as F or f depending on the absence or presence of the restriction site, respectively. The least increment in 25(OH)D was in ff (23.0 6 3.8 nmol/L) compared with Ff (31.2 6 3.4 nmol/L) and FF (35.6 6 2.7 nmol/L) (P for trend = 0.009), but only the difference between ff and FF was significant (P = 0.023). FF group had the largest decrement of both hsCRP and IL-6 compared with Ff (P < 0.001 and P = 0.038) and ff (P = 0.010 and P = 0.048), respectively. CONCLUSIONSdWe concluded that those of VDR ff genotype may be regarded as "low responders" to vitamin D intake in terms of response of circulating 25(OH)D and certain inflammatory biomarkers. A nutrigenetic approach may, therefore, be needed to protect diabetic patients from vitamin D deficiency. Copyright © 2013 by the American Diabetes Association.


Khoshgozaran-Abras S.,Tarbiat Modares University | Azizi M.H.,Tarbiat Modares University | Hamidy Z.,Tarbiat Modares University | Bagheripoor-Fallah N.,National Nutrition and Food Technology Research Institute
Carbohydrate Polymers | Year: 2012

The objective of the present study was to investigate the effect of Aloe vera gel incorporation at different proportions on chitosan-based films. Consequently, the thickness of films was affected significantly by the addition of the gel and decreased from F0 (plain chitosan film) to F50 (the film containing 50% gel). The gel incorporation did not have a considerable effect on water vapor permeability (WVP); however, a significant difference was observed for F50. Addition of the gel significantly improved the water solubility (WS), wherein the F10 (the film with 10% of gel) showed the lowest. All mechanical properties increased by introducing the gel and, after reaching the peak for F20, started to reduce. Color properties were affected by the gel addition as the higher the gel, the darker the films. Overall, the results showed that incorporating the gel into film-forming solution of chitosan up to 20% (F20) was promising. © 2011 Elsevier Ltd. All rights reserved.


Khoshgozaran S.,Tarbiat Modares University | Azizi M.H.,Tarbiat Modares University | Bagheripoor-Fallah N.,National Nutrition and Food Technology Research Institute
Dairy Science and Technology | Year: 2012

Dairy products are an important food group highly suggested by nutritionists. This food category is one of the most perishable, so extending their shelf life and keeping them fresh for a longer period of time is a matter of importance. Since consumers are now more aware of the possible hazards of preservatives, technologists and researchers have attempted to introduce novel preservative-free methods instead. One of these techniques is modified atmosphere packaging (MAP), which alters the natural gas surrounding the product in the package in order to delay deteriorative changes. In this paper, a review is made on the field of cheese MAP. Reported results revealed the potentiality of MAP in increasing cheese sensorial and microbial shelf life by carefully designing for an individual cheese. © 2011 Springer-Verlag.

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