Donetsk National Medical University

www.donnmu.com.ua/
Donets'k, Ukraine

Donetsk National Medical University of Maxim Gorky is one of the largest medical university of the former USSR. The University is considered as one of the best medical schools in Ukraine. Originally located in Donetsk, it was relocated to Krasnyi Lyman in 2014 due to the war in Donbass. Wikipedia.

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Limarenko M.P.,Donetsk National Medical University
Voprosy Detskoi Dietologii | Year: 2017

The article discusses the state of the liver in children with congenital heart diseases and chronic heart failure. The examination included 35 children. Congenital heart anomalies were represented by ventricular septal defect - in 28.5% of patients, secondary artial septal defect - in 22.8% of children, double outlet right ventricle - in 17.1% of patients, atrioventricular canal defect - in 14.3% of children, tetralogy of Fallot - in 8.6% of patients, etc. Combined congenital heart defects were diagnosed in 17.1% of children. Hepatosplenomegaly without impaired liver function was found in 74.3% of patients. In all cases, liver enlargement was associated with hemodynamic disorders and passive hepatic congestion.


Limarenko M.P.,Donetsk National Medical University
Voprosy Detskoi Dietologii | Year: 2016

The article deals with enzymopathies as one of possible causes of atopic dermatitis in children. Functional disorders of the digestive organs lead to absorption of incompletely digested food components, especially proteins, and thus contribute to the body' sensitization to various allergens. In atopic dermatitis in children the following functional disorders of the digestive organs are found: refluxes, dyskinesias, diseases of the mucous membrane, cholestasis, relative pancreatic insufficiency, gut dysbiosis. The task of the physician is to thoroughly examine such patients and administer complex therapy for atopic dermatitis taking into account diagnosed changes of the gastrointestinal tract.


Barinov E.F.,Donetsk National Medical University
Kardiologiya | Year: 2017

Circulating platelet-leukocyte aggregates (PLA) are present in patients with various diseases of the cardiovascular system and are considered as sensitive markers of platelet activation. At the same time characteristics of PLA in the circulating blood continue to be discussed in the context of the search for early markers of inflammation, which would bring us close to ability to limit the development of inflammatory response at the earliest stage. This review is devoted to analysis of studies of PLA in the context of assessment of functional activity of platelets and possibilities of cooperation of blood cells during activation of leukocytes at early stage of realization of inflammation process. Platelets are considered as important amplifiers of inflammation. Moreover, the extent and specificity of platelet-leukocyte interactions are determined by the spectrum of receptors on the blood cell surface triggering a variety of intracellular signaling pathways. The facts that the use of known pharmacological agents can result in inhibition of stimulated platelets, blocking the binding of activated platelets with leukocytes are provided. Accumulated knowledge creates the preconditions for simultaneous control of inflammatory and thrombotic processes in various diseases of cardiovascular system.


Borzenko B.G.,Donetsk National Medical University
Experimental oncology | Year: 2013

A comparative study of enzyme activity features of thymidilate "salvage pathway" synthesis in blood serum and tissues of different age patients with gastric cancer (T(3-4)N(0-x)M(0)) was carried out. To evaluate the diagnostic relevance of thymidilate metabolism enzymes activities and their association with tumor growth. Enzymes activities were determined by the radioisotope method and spectrophotometrically in tumor tissues and blood serum of 74 patients. It was demonstrated that thymidine phosphorylase activity in gastric tumors is lower by 2.6 times as compared to non-neoplastic mucosa of resection margin. This being accompanied by decrease of its activity in the blood serum (from 47.9 ± 2.6 to 14.65 ± 2.4 nmol/min·mg, p < 0.001). An increase of thymidine kinase activity was revealed both in tumor tissues (more than 3.5 times) and in blood serum (from 3.9 ± 0,7 nmol/mg·h, to 6.8 ± 1.0 nmol/mg·h, p < 0.01). Changes in their activity in the postoperative period depended on the type of surgical procedure and tumor eradication. It could be suggested that control of individual dynamics of the enzymes activities in blood serum may be used as informative tool for monitoring of patients and treatment optimization.


Barinov E.F.,Donetsk National Medical University
Kardiologiya | Year: 2016

One of major complications of ischemic heart disease is myocardial infarction, which develops as a result of thrombosis at the site of ruptured atherosclerotic plaque. Platelets activation and aggregation are the key events of this process. The efficiency of aspirin and/or clopidogrel use is limited by residual platelet reactivity what indicates the need to explore its mechanisms. This review covers intracellular signaling systems involved in realization of effects of the main platelet agonists in order to specify new molecules for the target therapy in case of aspirin resistance.


Dorofeyev A.E.,Donetsk National Medical University | Vasilenko I.V.,Donetsk National Medical University | Rassokhina O.A.,Donetsk National Medical University | Kondratiuk R.B.,Donetsk National Medical University
Gastroenterology Research and Practice | Year: 2013

Background. The mucus layer in the gastrointestinal tract plays important role in host innate defense, regulation of secretion, and absorption processes, maintaining colonization resistance, which composes the integrity of protective mucus barrier in the large intestine. Investigations of mucin expression in the colon mucosa can improve the understanding of protective function of mucosal barrier in ulcerative colitis (UC) and Crohn's disease (CD). Materials and Methods. 77 patients with UC and CD were examined. Histological analysis of colon mucosa was done by standard method (haematoxylin-eosin, alcian blue at pH 1.0 and 2.5 to determine sulfated and nonsulfated glycosaminoglycans and glycoproteins, and goblet cells). To characterize the mucus production the PAS-reaction was performed. Immunohistochemistry was performed using monoclonal mouse antibodies raised against MUC2, MUC3, MUC4, and TFF3 (USBiological, USA). Results. The moderate expression of MUC2 and MUC3 (50.0% and 32.1%, P = 0.03) and high expression of MUC4 and TFF3 in the colon mucosa were observed in all patients with CD. The intensive labeling of MUC4 and TFF3 occurred more often (42.9% and 57.1%, P = 0.03) in patients with CD. The level of expression of secretory MUC2 and transmembrane MUC3 and MUC4 in all patients with UC was low, up to its complete absence (59.2% and 53.1% cases, P = 0.05). TFF3 expression had high and medium staining intensity in patients with UC. Conclusions. Different types of mucins synthesis, secretion, and expression were found in patients with UC and CD. The expression of mucin MUC2, MUC3, MUC4, and TFF3 correlated with the activity of disease and the extent of the inflammatory process in the large intestine. The most pronounced alteration of mucins expression was observed in patients with severe UC and CD. © 2013 A. E. Dorofeyev et al.


Ganna S.,Donetsk National Medical University
Revista Brasileira de Reumatologia | Year: 2014

Objectives: The aim of this study was to evaluate the prevalence of anaemia in rheumatoid arthritis (RA). Patients and methods: 89 patients who fulfilled American College of Rheumatology (ACR) criteria for RA were included in this study. The mean disease duration was 10.9±8.8 years. All patients received methotrexate (10.5±5.5 mg/week) in combination with folic acid. Steroid hormones were prescribed to 92% (19.3±3.8 mg/day) of patients. Erythrocyte sedimentation rate (ESR) and levels of hemoglobin, C-reactive protein (CRP), tumour necrosis factor-alpha (TNFa) and interleukin-1 beta (IL-1ß) were evaluated in all patients. The World Health Organization (WHO) criteria for anaemia uses a hemoglobin threshold of <120 g/L for women and <130 g/L for men. Results: Anaemia was observed in 57 (64%) of the patients (1st group), the other patients (2nd group) had normal levels of hemoglobin (135.5±10.7 g/L). Duration and activity of RA were significantly higher (p<0.05) in the 1st group compared with the 2nd. ESR, CRP, TNFa, and IL- 1ß mean levels were significantly increased (p<0.05) in the 1st group when compared with the 2nd group. Negative correlations between hemoglobin level and ESR, CRP, TNFa, and IL- 1ß concentrations were observed. Conclusion: This study showed for the first time in Ukraine that in 46% of patients with RA, anaemia was diagnosed. A reduction of hemoglobin level was associated with a high activity of disease. © 2014 Sociedade Brasileira de Reumatologia.


Zuikov S.A.,Donetsk National Medical University
Advances in Gerontology | Year: 2015

The interrelationship between purine nucleotide exchange and the antioxidant system in blood plasma and erythrocytes with respect to age, as well as the contribution of key enzymes of purine decomposition in the formation of derivatives of reactive oxygen metabolites, were studied. Fifty conditionally healthy individuals aged 40–79 years were examined. An age-related increase in all indicators of the blood plasma prooxidant system was found. In blood plasma, the statistically significant correlation of the studied parameters and age of the examined individuals, as well as the relationship between glutathione peroxidase and adenosine deaminase/xanthine oxidase, adenosine deaminase and xanthine oxidase were observed. A significant increase in the content of products of protein oxidative modification was found in plasma and erythrocytes during aging. A decrease in the activity of key antioxidant enzymes, superoxide dismutase, and glutathione peroxidase with age was observed in blood plasma and erythrocytes. The data obtained are indicative of an imbalance in the antioxidant system in blood plasma and erythrocytes, with age contributing to the development of pathological states as a result of increased oxidative stress, which is greatly manifested in aging. © 2015, Pleiades Publishing, Ltd.


Zuikov S.A.,Donetsk National Medical University
Advances in Gerontology | Year: 2015

The interrelation of purine nucleotides with the antioxidant system in blood plasma and erythrocytes with respect to age, as well as the contribution of key enzymes of the purine decomposition to the formation of reactive oxygen species, were studied. Fifty conditionally healthy people aged 40–79 years (50 persons) were examined. All indicators of the pro-oxidant system of blood plasma were shown to increase with age. Statistically significant interrelations between the studied parameters in the blood plasma and age of the examined persons were found. Relationships between glutathione peroxidase and adenosine deaminase/xanthine oxidase, adenosine deaminase and xanthine oxidase were also demonstrated. A significant increase in the content of products of oxidative modification of proteins in plasma and erythrocytes was observed with aging. It was shown that key enzymes of antioxidant protection, i.e., superoxide dismutase and glutathione peroxidase, were reduced in blood plasma and erythrocytes with age. The results indicate that an imbalance in the antioxidant system occurs with age in blood plasma and erythrocytes, and this process contributes to the development of pathological conditions by increasing oxidative stress, which is especially pronounced with age. © 2015, Pleiades Publishing, Ltd.


Gorshkov O.,Donetsk National Medical University
AIP Conference Proceedings | Year: 2013

We suggest an algorithm for the estimation of the largest Lyapunov exponent for one-dimensional domains. We evaluate the largest Lyapunov exponent for one-dimensional domains, which present the surrogate long-range correlated stochastic time series with Hurst exponent H=0.1, H=0.9, H=0.5. It has been established that for an anticorrelated time series with the Hurst exponent H=0.1, the largest Lyapunov exponent is positive. For a correlated time series with Hurst exponent H=0.9, the largest Lyapunov exponent is negative. Also for a classical random walk with Hurst exponent H=0.5, the largest Lyapunov exponent is close to zero. © 2013 AIP Publishing LLC.

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