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Kaohsiung, Taiwan

The National Kaohsiung Normal University , founded in 1967, is a public university located in Lingya District, Kaohsiung, Taiwan. The university has two campuses — Ho-Ping and Yen-Chao. The University currently has five colleges: College of Education, College of Humanities, College of Science, College of Technology, and College of Arts. Wikipedia.

Lin H.,National Kaohsiung Normal University
Applied Optics | Year: 2010

A waveband-tunable multiwavelength erbium-doped fiber laser based on a novel integrated structure of nonlinear polarization rotation and an unbalanced in-line Sagnac interferometer is proposed and demonstrated. An ultrabroadband lasing spectrum with 140 wavelength lasing peaks periodically distributed from 1563 to 1612:5nm accompanied by a lasing linewidth of 0:112nm, a free spectral range (FSR) of 0:32 nm, and a signal-to-noise ratio (SNR) of 20dB has been achieved. A laser with high-wavelength lasing and waveband tunability was also achieved by merely adjusting the polarization controllers. The wavebands can be tuned from 1567 to 1606nm continuously. Thirty-one lasing wavelengths in a 3dB flattened spectrum has been achieved with a SNR of 48dB, a linewidth of 0:03nm, and a FSR of 0:32 nm. Good stability of the laser operating at room temperature has been verified by using an optical spectrum analyzer to measure every 2 min for a half-hour. © 2010 Optical Society of America. Source

Lin H.-R.,National Kaohsiung Normal University
Bioorganic and Medicinal Chemistry Letters | Year: 2012

Alisma orientalis is a well-known traditional medicine exerting pharmacological effects including antidiabetes, antihepatitis, and antidiuretics, but the respective molecular mechanism is not completely clear. Farnesoid X receptor (FXR) is a member of nuclear receptor superfamily and viewed as one of the essential target proteins to develop antidiabetic treatments. In this study, the triterpenes, alisol M 23-acetate and alisol A 23-acetate, were isolated from A. orientalis and further evaluated for their activity against FXR. In the mammalian one-hybrid and transient transfection reporter assays, both triterpenes transactivated FXR to modulate promoter action including GAL4, SHP, CYP7A1, and PLTP promoters in dose-dependent manner, while they exhibited similar agonistic activity as chenodeoxycholic acid (CDCA), an endogenous FXR agonist. These results highly indicated that alisol M 23-acetate and alisol A 23-acetate acted as FXR agonists so A. orientalis might exert therapeutic effect including antihyperglycemic effect through FXR pathway. © 2012 Elsevier Ltd. All rights reserved. Source

Chen J.-C.,National Kaohsiung Normal University
IEEE Transactions on Broadcasting | Year: 2010

This paper proposes a reduced-complexity partial transmit sequences (PTS) approach based on the quantum-inspired evolutionary algorithm (QEA) for the reduction of peak-to-average power ratio (PAPR) in an orthogonal frequency division multiplexing (OFDM) system. The conventional PTS technique improves the PAPR statistics for OFDM signals, but the considerable computational complexity for an exhaustive search over all combinations of allowed phase factors is a potential problem for practical implementation. To reduce the computational complexity while still obtaining the desirable PAPR reduction, we introduce the QEA, an effective algorithm that solves various combinatorial optimization problems, to search the optimal phase factors. The simulation results show that the proposed QEA achieves significant PAPR reduction with low computational complexity. © 2006 IEEE. Source

Hsu H.J.,National Kaohsiung Normal University | Bishop D.V.M.,University of Oxford
Developmental Science | Year: 2014

This study tested the procedural deficit hypothesis of specific language impairment (SLI) by comparing children's performance in two motor procedural learning tasks and an implicit verbal sequence learning task. Participants were 7- to 11-year-old children with SLI (n = 48), typically developing age-matched children (n = 20) and younger typically developing children matched for receptive grammar (n = 28). In a serial reaction time task, the children with SLI performed at the same level as the grammar-matched children, but poorer than age-matched controls in learning motor sequences. When tested with a motor procedural learning task that did not involve learning sequential relationships between discrete elements (i.e. pursuit rotor), the children with SLI performed comparably with age-matched children and better than younger grammar-matched controls. In addition, poor implicit learning of word sequences in a verbal memory task (the Hebb effect) was found in the children with SLI. Together, these findings suggest that SLI might be characterized by deficits in learning sequence-specific information, rather than generally weak procedural learning. © 2014 The Authors. Developmental Science Published by John Wiley & Sons Ltd. Source

Lin H.-R.,National Kaohsiung Normal University
Bioorganic and Medicinal Chemistry Letters | Year: 2012

Tithonia diversifolia is a well-known traditional Chinese medicine treating diabetes, hepatitis, and hepatocarcinoma but its molecular mechanism is not fully understood. Peroxisome proliferator-activated receptors (PPARs) α and γ are members of nuclear receptor superfamily. Their agonists are prescribed as antihyperlipidemic and antihyperglycemic drugs now. In this study, sesquiterpene lactones, tirotundin and tagitinin A, were isolated from T. diversifolia and evaluated for their activity against PPARs by the transient transfection reporter assay. Tirotundin and tagitinin A transactivated PPARγ dependent promoters including PPRE (PPARγ response element), SHP, and ABCA1 gene promoters in dose-dependent manner. Furthermore, the fluorescence polarization competitive binding assay showed that tirotundin (IC 50 = 27 μM) and tagitinin A (IC 50 = 55 μM) enhanced PPARγ transactivation activity by directly binding to PPARγ ligand binding domain. Additionally, they stimulated the transactivation of PPARα dependent SULT2A1 gene promoter by 2.3-fold of vehicle effect at 10 μM. These results highly indicated that tirotundin and tagitinin A are the active components of T. diversifolia to exert anti-diabetic effect through PPARγ pathway. Moreover, these sesquiterpene lactones behaved as PPARα/γ dual agonists so they might be useful as the potential herbal treatment for diabetes. © 2012 Elsevier Ltd. All rights reserved. Source

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